Professor David G Lambert

Professor Dave LambertProfessor of Anaesthetic Pharmacology
Director Post Graduate Research, College of Medicine, Biological Sciences and Psychology

Tel: 0116 252 3161

Email: dgl3@le.ac.uk

Address: Department of Cardiovascular Sciences, Division of Anaesthesia Critical Care & Pain Management, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX

Personal details

BSc  (First class honours) in Biological Sciences, University of Aston in Birmingham, 1984
PhD “Insulin release from cultured beta-cells”, University of Aston in Birmingham, 1987

External positions and distinctions

Member of Grant Awards Committee of BJA/RCoA., 2000
Visiting Professor to The University of Hirosaki, Japan, 1998, 2001-present 
The Humphry Davy Medal awarded by The Royal College of Anaesthetists, 2002
Chair BJA/RCoA grants committee, 2002.
Edmund Riding Professor of The Royal College of Anaesthetists, 2003 
Grants Officer for BJA/RCoA, 2003.
Visiting Professor to The University of Kyushu, Japan, 2004.
Associate Editor for The British Journal of Anaesthesia 
Member Academic and Research Committee of RCoA
Member of the Anaesthetic Research Society, 1994-2004 
Member of The European Society of Anaesthesiologists Pharmacology Sub-Committee
Member of the British Pharmacological Society and the European Opioid Colloquim
Consultant for Pfizer Veterinary Medicine, 2003-2004
Pharmacology Specialty Editor for Anaesthesia & Intensive Care Medicine, 2005

Publications

Recent papers

Papers before 2008

Recent reviews and book chapters

Books

Molinari S, Camarda V, Rizzi A, Marzola G, Salvadori S, Marzola E, Molinari P, McDonald J, Ko MC, Lambert DG, Calo' G, Guerrini R. [Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist. Br J Pharmacol. 2013 Jan;168(1):151-62

Brookes ZL, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, Reilly CS, Lambert DG. The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PLoS One. 2013 Sep 23;8(9):e74943

Dietis N, McDonald J, Molinari S, Calo G, Guerrini R, Rowbotham DJ, Lambert DG. Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505). Br J Anaesth. 2012 Feb;108(2):262-70

Research

Nociceptin receptors

In collaboration with Dr G Calo and Prof Rowbotham
SAR-N/OFQ.
NOP desensitisation, recombinant and native. Transduction and genomic studies.
Cardiovascular effects of N/OFQ (collaborative with Dr Z Brookes, Sheffield)
Species differences in NOP/N/OFQ.
Measurement of N/OFQ in biological fluids.

Classical Opioid receptors

In collaboration with Dr G Calo, Prof Rowbotham and Dr JP Thompson
Basic pharmacology and comparison of recombinant MOP/DOP/KOP.
Measuring opioid receptors on lymphocytes and clinical utility.

Vanilloid (VR1) receptors

In collaboration with GSK and Dr A Hainsworth of DMU
Basic pharmacology.
Desensitisation (comparison with GPCR).
Comparison of anandamide action at VR1 and CB receptors.
Capsaicin and apoptosis.

Urotensin II

In collaboration with Dr G Calo, Prof LL Ng, Dr J Thompson, Prof Rowbotham and GSK
Evaluation of the urotensin II/UT receptor system.
SAR of the peptide and its actions in recombinant and native systems.
UT desensitization.
Measurement of urotensin II in plasma and CSF in normotensive and hypertensive populations.

BBSRC Funded Biosensor Development (Biosensor based approach to measure release of Nociceptin/Orphanin FQ from live single immune cells and consequences for immune cell function)

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