Dr Kazi Asif Adnan

Clinical Research Fellow and MD student

Tel: 0116 250 2502

Email: kaa31@le.ac.uk

Address: Department of Cardiovascular Sciences, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP

Education and training:

2001: MBBS (Dhaka Medical College, Dhaka University, Bangladesh)
2007: MRCP (UK), Royal College of Physicians
2010- current: Holder of National Training Number (NTN) in Cardiology,
East Midlands Deanery (fellow in intervention cardiology)

Memberships and affiliations:

General Medical Council (GMC)
British Cardiovascular Society (BCS), British Junior Cardiologists’ Association (BJCA) & British Cardiovascular Intervention Society (BCIS)
Resuscitation Council UK (RCUK) accredited Advanced Life Support (ALS) Instructor

MD Project

Project title:

The novel application of coronary optical coherence tomography (OCT) and computational fluid dynamic (CFD) modelling as an adjunct to post-mortem computed tomographic angiography (PMCTA) to aid minimally invasive autopsy.

Overview 

In this research, we set out to investigate the role of coronary optical coherence tomography (OCT) and potential application of computational fluid dynamic (CFD) modelling as an adjunct to an established post mortem computed tomographic angiography technique. The results will be compared against the findings of a pathologist performing conventional autopsy.

Figure: OCT of a repressurised cadaveric coronary artery showing a ‘mixed’ plaque (calcified and fibro fatty component) causing luminal stenosis which can be accurately quantified at sub-millimetre levelOCT is an intra-coronary catheter based imaging technology with a resolution of 10-20 microns and has very high level and accurate correlation to histology. This provides the most robust anatomical information about coronary luminal stenosis and histological nature of the plaque. On the other hand, CFD modelling is a well-established simulation method in many fields of engineering. In recent years, researchers have started to apply this for modelling blood flow. We hypothesize that application of CFD modelling using the rich anatomical data from CT/OCT co-registration will provide an objective assessment of anatomical and functional significance of a stenosis and thus prove to be equivalent, if not superior, to conventional autopsy techniques.

These techniques, if established, will help in reducing the number of ‘open’ autopsies significantly while also will provide fresh insight into the disease processes leading to cardiovascular deaths with implications for patients’ risk stratification and clinical care.

Supervisors: Dr David Adlam and Professor Bruno Morgan (Cancer Studies & Molecular Medicine)

Publications

Peer reviewed:

Coats TJ, Morgan B, Robinson C, Biggs M, Adnan A, Rutty G. End-tidal CO2 detection during cadaveric ventilation. Emergency Medicine Journal. 2015; 32(9): 753-4.

Joseph S, Adnan A, Subhash HM, Leahy M, Adlam D. Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systems. Biomedical Optics Express. 2015; 6(3): 668.

Adlam D, Morgan B, Robinson C, Biggs M, Adnan A, Rutty GN, … Lambrechtsen J. Letter to the Editor- Optimisation of post-mortem cardiac computed tomography compared to optical coherence tomography and histopathology – Technical note. Journal of Forensic Radiology and Imaging. 2014; 2(3), 158

Book Chapter:

Adnan, A., & Adlam, D. (2014). Coronary Artery Disease and Acute Coronary Syndrome. In T. England & A. Nasim (Eds.), ABC of Arterial and Venous Disease (3rd ed., pp. 17–24). WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA.

Oral Presentation:

‘Investigating the role of Coronary Optical Coherence Tomography (OCT) in minimally invasive Autopsy’ – ISFRI/IAFR Congress 2015, Leicester , UK

Links

Department of Cardiovascular Sciences

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