Dr Karl E Herbert

Dr Karl Herbert Senior Lecturer

BSc (Hons) Applied Biochemistry, First Class, 1982, Brunel University
PhD, 1986, The Medical College of St. Bartholomew's Hospital, University of London

Tel: +44 (0)116 258 3046

Email: keh3@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP

Personal details

BSc (Hons), PhD

I have a BSc and PhD and currently work as Senior Lecturer within the Department of Cardiovascular Sciences at the University of Leicester. I am also member of the Society for Redox Biology and Medicine.

Publications


Abbasian N, Burton JO, Herbert KE, Tregunna BE, Brown JR, Ghaderi-Najafabadi M, Brunskill NJ, Goodall AH, Bevington A. Hyperphosphataemia, phosphoprotein phosphatases and microparticle release in vascular endothelial cellsJ Am Soc Nephrol. 2015 Sep;26(9):2152-62

Dott W, Mistry P, Wright J, Cain K, Herbert KE. Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicityRedox Biol. 2014 Jan 10;2:224-233.

Webb Dr, Davies MJ, Herbert K, Khunti K, Sattar N, Stehouwer CDA. Biomarker research in glucose disorders: Current concepts and clinical applicationsJ Diabetes Res. 2013;2013:290671.

Mistry Y, Poolman T, Williams B, Herbert KE. A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cellsRedox Biol. 2013 Aug 26;1(1):411-7

Malik Q, Herbert KE. Oxidative and non-oxidative DNA damage and cardiovascular diseaseFree Rad Res 2012 Apr;46(4):554-564.

Ehsan S, Ball G, Choke E, Molyneux KM, London NJ, Herbert KE, Barratt J, Sayers RD, Bown MJ. Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry. Eur J Vasc Endovasc Surg. 2012 Jul;44(1):52-4.

Wilson WR, Herbert KE, Mistry Y, Stevens SE, Patel HR, Hastings RA, Thompson MM, Williams B. Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular diseaseEur Heart J. 2008 Nov 29 21 2689-94

Herbert KE, Mistry Y, Hastings R, Poolman T, Niklason L, Williams B. Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathwaysCirc Res. 2008 Feb 1 102 2 201-8

Herbert KE, Fletcher S, Chauhan D, Ladapo A, Nirwan J, Munson S, Mistry P. Dietary supplementation with different vitamin C doses: no effect on oxidative DNA damage in healthy peopleEur J Nutr. 2006 Mar 45 2 97-104

Hastings R, Li NC, Lacy PS, Patel H, Herbert KE, Stanley AG, Williams B. Rapid telomere attrition in cardiac tissue of the ageing Wistar ratExp Gerontol. 2004 May 39 5 855-7

Cooke MS, Podmore ID, Mistry N, Evans MD, Herbert KE, Griffiths HR, Lunec J. Immunochemical detection of UV-induced DNA damage and repairJ Immunol Methods. 2003 Sep 280 1-2 125-33

Mistry P, Herbert KE. Modulation of hOGG1 DNA repair enzyme in human cultured cells in response to pro-oxidant and antioxidant challengeFree Radic Biol Med. 2003 Aug 15 35 4 397-405

Cooke MS, Mistry N, Ahmad J, Waller H, Langford L, Bevan RJ, Evans MD, Jones GD, Herbert KE, Griffiths HR, Lunec J. Deoxycytidine glyoxal: lesion induction and evidence of repair following vitamin C supplementation in vivo. Free Radic Biol Med. 2003 Jan 15 34 2 218-25

Ravanat JL, Douki T, Duez P, Gremaud E, Herbert K, Hofer T, Lasserre L, Saint-Pierre C, Favier A, Cadet J. Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-upCarcinogenesis. 2002 Nov 23 11 1911-8

Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P and Lunec J Vitamin C exhibits pro-oxidant properties Nature 1998  392  559

 

Research

  • Molecular and cellular mechanisms of cardiovascular ageing

  • Oxidative DNA damage and repair in humans

  • Mitochondria and cellular oxidative stress

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