Professor Alison H Goodall

Professor of Thrombosis and Haemostasis Professor Alison H Goodall

BSc (Biology), 1971, University of London
PhD (Biochemistry), 1979, University of London

Tel: 0116 258 3026

Email: ahg5@le.ac.uk

Address: Department of Cardiovascular Sciences, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP

Head of Department of Genetics & Genome Biology

Tel: 0116 252 3019

PA: 0116 252 3438 sll6@le.ac.uk

Address: Room 213A Adrian Building University of Leicester, University Road, Leicester, LE1 9HN


Research Interests

  • Haemostatic regulation in atherothrombotic diseases
  • Platelet biology
  • Functional genomics of platelets and haemostasis
  • Genetics of cardiovascular disease
  • Platelets and cancer
  • Platelet transfusion

 

External Positions

Current:
External examiner, UCL MSc in Cardiovascular Science

Past:
Non-Executive Director UHL Trust Board 2016-2017
Principal Editor: Platelets https://www.tandfonline.com/toc/iplt20/current 2009-2017
Member of the NIHR Doctoral Training Fellowship Panel 2005-2010
Reviews Editor: Platelets 2005-2009
Committee Member: British Atherosclerosis Society http://www.britathsoc.org/ 2001-2004
President: British Society for Haemostasis & Thrombosis https://bsht.org.uk/ 2001-2003
Editor-in-Chief: Clinical Science 2001-2003
Editorial Board of Clinical Science, 1995-2001 (Associate Editor for Cardiovascular Section, 2002-2006)
Committee Member; British Society for Haemostasis & Thrombosis 1996-2001

Commercial Links

Founding Director of a University Spin-out company, Haemostatix Ltd, developing novel first-in-class clotting agents for the treatment of bleeding. Haemostatix Ltd was bought by Ergomed PLC in 2016

Membership of Learned Societies

International Society for Extracellular Vesicles, 2012- 
International Society on Thrombosis & Haemostasis, 1999- 
British Atherosclerosis Society, 1994- 
British Society for Haemostasis & Thrombosis, 1982- 
British Society for Haematology, 1997-2011 
Association of Clinical Biochemists 1997-2001 
British Society for Immunology 1979-1995 
British Society for Cell Biology 1976-1986 
Biochemical Society 1975-1986

Key Publications

Collier ME, Ettelaie C, Goult BT, Maraveyas A, Goodall AH. Investigation of the Filamin A-Dependent Mechanisms of Tissue Factor Incorporation into Microvesicles. Thrombosis & Haemostasis 2017 Nov;117(11):2034-44. doi: 10.1160/TH17-01-0009.

Ambrose AR., Alsahli MA, Kurmani SA, Goodall AH. Comparison of the release of microRNAs and extracellular vesicles from patients in response to different agonists. Platelets. 2017 Jul 20:1-9. doi: 10.1080/09537104.2017.1332366

Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, Wiltshire M, Morris T, Nath M, Bittar N, Bhudia SK, Kumar T, Goodall AH, Murphy GJ. Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. British Journal of Anaesthesia. 2017 May 1;118(5):689-698. doi: 10.1093/bja/aex083

Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP. Evidence for Shear-mediated Ca2+ Entry through Mechanosensitive Cation Channels in Human Platelets and a Megakaryocytic Cell Line. Journal of Biological Chemistry. 2017(Jun 2); 292(22)9204-9217. doi: 10.1074/jbc.M116.766196.

Collier ME, Akinmolayan A, Goodall AH. Comparison of tissue factor expression and activity in foetal and adult endothelial cells. Blood Coagulation & Fibrinolysis. 2017 Sept; 28(6): 452-459. doi: 10.1097/MBC.0000000000000621.

Wright JR, Amisten S, Goodall AH, Mahaut-Smith MP. Transcriptomic analysis of the ion channelome of human platelets and megakaryocytic cell lines. Thrombosis & Haemostasis. 2016 Aug 1;116(2):272-84. doi: 10.1160/TH15-11-0891.

Riegger J, Byrne RA, Joner M, Chandraratne S, Gershlick AH, Ten Berg JM, Adriaenssens T, Guagliumi G, Godschalk TC, Neumann FJ, Trenk D, Feldman LJ, Steg PG, Desmet W, Alfonso F, Goodall AH, Wojdyla R, Dudek D, Philippi V, Opinaldo S, Titova A, Malik N, Cotton J, Jhagroe DA, Heestermans AA, Sinnaeve P, Vermeersch P, Valina C, Schulz C, Kastrati A, Massberg S; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort PRESTIGE Investigators. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. European Heart Journal. 2016 May 14;37(19):1538-49. doi: 10.1093/eurheartj/ehv419.

CARDIoGRAMplusC4D Consortium. 2015. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics. 47(10): 1121-30. doi: 10.1038/ng.3396

Good RI, McGarrity A, James TE, Miller H, McConnachie A, Goodall AH, Oldroyd KG. Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response. Thrombosis Research. 2015;135(6):1140-6

Abbasian N, Burton JO, Herbert KE, Tregunna B-E, Brown JR, Ghaderi-Najafabadi M, Brunskill NJ, Goodall AH, Alan Bevington A. Hyperphosphataemia signalling through global phosphoprotein phosphatase inhibition drives Tropomyosin accumulation and pro-coagulant microparticle release in human vascular endothelial cells. Journal of the American Society of Nephrology 2015 Sep;26(9):2152-62. doi: 10.1681/ASN.2014070642.

Rocanin-Arjo A, Cohen W, Carcaillon L, Frère C, Saut N, Letenneur L, Alhenc-Gelas M, Dupuy AM, Bertrand M, Alessi MC, Germain M, Wild PS, Zeller T, Cambien F, Goodall AH, Amouyel P, Scarabin PY, Trégouët DA, Morange PE. A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential. Blood. 2014 Jan 30;123(5):777-85. doi: 10.1182/blood-2013-10-529628

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