Professor Alison H Goodall

Professor of Thrombosis and Haemostasis Professor Alison H Goodall

BSc (Biology), 1971, University of London
PhD (Biochemistry), 1979, University of London

Tel: 0116 258 3026

PA: 0116 258 2945 /2921

Email: ahg5@le.ac.uk

Address: Department of Cardiovascular Sciences, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP

Deputy Head of College of Medicine, Biological Sciences and Psychology

Tel: 0116 252 2927

PA: 0116 252 2962 /5606

Address: Maurice Shock Building, University of Leicester, University Road, Leicester, LE1 9HN

Research Interests

  • Haemostatic regulation in atherothrombotic diseases

  • Platelet biology

  • Functional genomics of platelets and haemostasis

  • Genetics of cardiovascular disease

  • Platelet transfusion

  • Platelets and cancer

External Positions

Current:
Principal Editor: Platelets 2009-
Non-Executive Director UHL Trust Board

Past:
Member of the NIHR Doctoral Training Fellowship Panel 2005-2010
Reviews Editor: Platelets 2005-2009
Committee Member: British Atherosclerosis Society 2001-2004
President: British Society for Haemostasis & Thrombosis 2001-2003
Editor-in-Chief: Clinical Science 2001-2003
Editorial Board of Clinical Science, 1995-2001 (Associate Editor for Cardiovascular Section, 2002-2006)
Committee Member; British Society for Haemostasis & Thrombosis 1996-2001

Commercial Links

Founding Director of a University Spin-out company, Haemostatix Ltd., developing novel first-in-class clotting agents for the treatment of bleeding.

Membership of Learned Societies

International Society for Extracellular Vesicles, 2012-
International Society on Thrombosis & Haemostasis, 1999-
British Atherosclerosis Society, 1994-
British Society for Haemostasis & Thrombosis, 1982-
British Society for Haematology, 1997-2011
Association of Clinical Biochemists 1997-2001
British Society for Immunology 1979-1995
British Society for Cell Biology 1976-1986
Biochemical Society 1975-1986

Key Publications

Riegger J, Byrne RA, Joner M, Chandraratne S, Gershlick AH, Ten Berg JM, Adriaenssens T, Guagliumi G, Godschalk TC, Neumann FJ, Trenk D, Feldman LJ, Steg PG, Desmet W, Alfonso F, Goodall AH, Wojdyla R, Dudek D, Philippi V, Opinaldo S, Titova A, Malik N, Cotton J, Jhagroe DA, Heestermans AA, Sinnaeve P, Vermeersch P, Valina C, Schulz C, Kastrati A, Massberg S. 2016. Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort PRESTIGE Investigators. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. European Heart Journal. 37(19): 1538-49.

CARDIoGRAMplusC4D Consortium. 2015. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nature Genetics. 47(10): 1121-30.

Good RI, McGarrity A, James TE, Miller H, McConnachie A, Goodall AH, Oldroyd KG. 2015. Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response. Thrombosis Research. 135(6): 1140-6.

Abbasian N, Burton JO, Herbert KE, Tregunna B-E, Brown JR, Ghaderi-Najafabadi M, Brunskill NJ, Goodall AH,  Alan Bevington A. 2015. Hyperphosphataemia signalling through global phosphoprotein phosphatase inhibition drives Tropomyosin accumulation and pro-coagulant microparticle release in human vascular endothelial cells. J Am Soc Nephrol. 26(9): 2152-62.

Everett TR, Garner SF, Lees CC, Goodall AH. 2014. Immature platelet fraction analysis demonstrates a difference in thrombopoesis between normotensive and preeclamptic pregnancies. Thrombosis & Haemostasis. 111(6): 1177-9.

Rocanin-Arjo A, Cohen W, Carcaillon L, Frère C, Saut N, Letenneur L, Alhenc-Gelas M, Dupuy AM, Bertrand M, Alessi MC, Germain M, Wild PS, Zeller T, Cambien F, Goodall AH, Amouyel P, Scarabin PY, Trégouët DA, Morange PE. 2014. A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential. Blood. 123(5): 777-85.

Burton JO, Hamali HA, Singh R, Abbasian N, Parsons R, Patel AK, Goodall AH, Brunskill NJ. 2013. Elevated levels of procoagulant plasma microvesicles in dialysis patients. PLoS One. 8(8): e72663.

McMahon GS, Jones CI, Hayes PD, Naylor AR, Goodall AH. 2013. Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial. Thrombosis & Haemostasis. 109(6): 1099-1107.

Garnier S, Truong V, Brocheton J, Zeller T, Rovital M, Wild PS, Ziegler A; Cardiogenics Consortium, Munzel T, Tiret L, Blankenberg S, Deloukas P, Erdmann J, Hengstenberg C, Samani NJ, Schunkert H, Ouwehand WH, Goodall AH, Cambien F, Trégouët DA. 2013. Genome-wide haplotype analysis of cis expression quantitative trait Loci in monocytes. PLoS Genet. 9(1): e1003240.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM. 2011. BCL2/BCL-XL-inhibition induces apoptosis, disrupts cellular calcium homeostasis and prevents platelet activation. Blood. 117(26): 7145-54.

Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O’Connor MN, Rice CM, Stemple D, Stephens J, Trip MD, Zwaginga J-J, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH, on behalf of the Bloodomics Consortium. 2010. Transcription Profiling in Human Platelets Reveals LRRFIP1 as a Novel Protein Regulating Platelet Function. Blood. 116(22): 4646-4656.

 

Links

Recent Papers

Research Group

Facilities

Share this page: