Dr Marcin Wozniak

Marcin WozniakLecturer

BSc/MSc (Biotechnology), 1999, University of Wroclaw, Poland
PhD 2003, University of Tübingen, Germany

Email: mw299@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP

Research

My research focuses on aspects of organ injury in cardiac surgery patients:

• Novel biomarker discovery for acute kidney injury;
• Mechanisms underlying endothelial dysfunction in AKI;
• Complications associated with massive blood transfusion.
We use a range of techniques that includes the next generation sequencing, flow cytometry, microscopy-based in vitro models of inflammation and combine it with bioinformatics and statistical analysis.

 

Collaborations
Prof. Eugene Yu-Dong Zhang, https://www2.le.ac.uk/departments/informatics/people/yudong-zhang
Dr Nic Sylvius (NUCLEUS genomics facility), https://www2.le.ac.uk/colleges/medbiopsych/facilities-and-services/cbs/nucleus
Leicester Single-Cell Biology Group https://www44.lamp.le.ac.uk/leicester_scbg/
Dr Mintu Nath (University of Aberdeen) https://shiny.lcbru.le.ac.uk/mnath/

 

Recent Publications
Yusoff SI, Roman M, Lai FY, Eagle-Hemming B, Murphy GJ, Kumar T, Wozniak M Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors. Transl Res. 2019 Mar;205:1-16.

Aujla H, Kumar T, Woźniak M, Dott W, Sullo N, et al. Effect of sildenafil (Revatio) on postcardiac surgery acute kidney injury: a randomised, placebo-controlled clinical trial: the REVAKI-2 trial protocol. Open Heart. 2018;5(2):e000838.

Sullo N, Mariani S, JnTala M, Kumar T, Woźniak MJ, et al. An Observational Cohort Feasibility Study to Identify Microvesicle and Micro-RNA Biomarkers of Acute Kidney Injury Following Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2018 Sep;19(9):816-830.

Aujla H, Woźniak M, Kumar T, Murphy GJ. Rejuvenation of allogenic red cells: benefits and risks. Vox Sang. 2018 Jun 4.

Singleton BK, Ahmed M, Green CA, Heimpel H, Woźniak MJ, et al. CD44 as a Potential Screening Marker for Preliminary Differentiation Between Congenital Dyserythropoietic Anemia Type II and Hereditary Spherocytosis. Cytometry B Clin Cytom. 2018 Mar;94(2):312-326.

Woźniak MJ, Qureshi S, Sullo N, Dott W, Cardigan R, et al. A Comparison of Red Cell Rejuvenation versus Mechanical Washing for the Prevention of Transfusion-associated Organ Injury in Swine. Anesthesiology. 2018 Feb;128(2):375-385.

Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, et al. Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery. Br J Anaesth. 2017 May 1;118(5):689-698.

Ring A, Morris T, Wozniak M, Sullo N, Dott W, et al. A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (Revatio<sup>®</sup> ) in cardiac surgery: the REVAKI-1 study. Br J Clin Pharmacol. 2017 Apr;83(4):709-720.

Mariscalco G, Wozniak MJ (1st co-authorship), Dawson AG, Serraino GF, Porter R, et al. Body Mass Index and Mortality Among Adults Undergoing Cardiac Surgery: A Nationwide Study With a Systematic Review and Meta-Analysis. Circulation. 2017 Feb 28;135(9):850-863.

Ruane PT, Gumy LF, Bola B, Anderson B, Wozniak MJ, et al. Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2. Sci Rep. 2016 Jun 7;6:27456.

Lucas G, Poles A, Woźniak MJ, Gilmore R. Further observations on the clinical significance and inheritance of the low-frequency platelet antigen HPA-28bw. Transfusion. 2016 Apr;56(4):873-7.

Murphy GJ, Verheyden V, Wozniak M, Sullo N, Dott W, et al. Trial protocol for a randomised controlled trial of red cell washing for the attenuation of transfusion-associated organ injury in cardiac surgery: the REDWASH trial. Open Heart. 2016;3(1):e000344.

Murphy GJ, Mumford AD, Rogers CA, Wordsworth S, Stokes EA, Verheyden V, Kumar T, Harris J, Clayton G, Ellis L, Plummer Z, Dott W, Serraino F, Wozniak M, Morris T, Nath M,

Sterne JA, Angelini GD, Reeves BC Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials. Southampton (UK): NIHR Journals Library; 2017Sep.

 

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