Dr Veryan Codd

Lecturer

Department of Cardiovascular Sciences
University of Leicester
BHF Cardiovascular Research Centre
Glenfield Hospital
Leicester, LE3 9QP

Email: vc15@le.ac.uk

Personal details

  • BSc (Hons) Genetics, University of Wales, Aberystwyth, 1998
  • MRes, University of Leicester, 1999
  • PhD, University of Leicester, 2003

Membership of learned societies

  • British Society for Cardiovascular Research

Websites

Publications

Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE; ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma riskNat Genet., 46(7), pp. 731-735.

Deelen J, Beekman M, Codd V, Trompet S, Hägg S, Broer L, Fischer K, Thijssen PE, Suchiman HED, de Craen AJM, Metspalu A, van Duijn CM, Pedersen N, Jukema JW, Samani NJ, Slagboom PE. (2014). Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers.Int J Epidemiol., 43(3), pp. 878-86.

Huzen J, Wong LS, van Veldhuisen DJ, Samani NJ, Zwinderman AH, Codd V, Cawthon RM, Benus GF, van der Horst IC, Navis G, Bakker SJ, Gansevoort RT, de Jong PE, Hillege HL, van Gilst WH, de Boer RA, van der Harst P. (2014). Telomere length loss due to smoking and metabolic traitsJ Intern Med., 275(2), pp. 155-63.

Broer L, Codd V, Nyholt DR, Deelen J, Mangino M, Willemsen G, Albrecht E, Amin N, Beekman M, de Geus EJC, Henders A, Nelson CP, Steves CJ, Wright MJ, de Craen AJM, Isaacs A, Matthews M, Moayyeri A, Montgomery GW, Oostra BA, Vink JM, Spector TD, Slagboom PE, Martin NG, Samani NJ, van Duijn CM, Boomsma DI. (2013). Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effectEur J Hum Genet., 21(10), pp. 1163-8.

Denham J, Nelson CP, O'Brien BJ, Nankervis SA, Denniff M, Harvey JT, Marques FZ, Codd V, Zukowska-Szczechowska E, Samani NJ, Tomaszewski M, Charchar FJ. (2013). Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factorsPLoS One. 8(7), p. e69377.

Codd V, Nelson CP, Albrecht E, Mangino M et al. (2012). Identification of seven loci affecting mean telomere length and their association with diseaseNature Genetics, 45(4), pp. 422-7.

Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Mateo Leach I, de Boer RA, Kimura M, Aviv A; Wellcome Trust Case Control Consortium, Goodall AH, Ouwehand W, van Veldhuisen DJ, van Gilst WH, Navis G, Burton PR, Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ. (2010). Common variants near TERC are associated with mean telomere length. Nat Genet., 42(3), pp. 197-9.

Kuznetsova T, Codd V, Brouilette S, Thijs L, Gonzales A, Jin Y, Richart T, van der Harst P, Diez J, Staessen JA, Samani NJ. (2010). Association between Left Ventricular Mass and Telomere Length in a Population StudyAm. J. Epidemiol., 172(4), pp. 440-50.

Diaz VA, Mainous AG 3rd, Everett CJ, Schoepf UJ, Codd V, Samani NJ. (2010). Effect of healthy lifestyle behaviors on the association between leukocyte telomere length and coronary artery calciumAm J Cardiol., 106(5), pp. 659-63.

Wong LSM, Huzen J , van der Harst P, de Boer RA, Codd V, Westenbrink BD, Benus GFDJ, Voors AA,  van Gilst WH,  Samani NJ, Jaarsma T, van Veldhuisen DJ. (2010). Anaemia is associated with shorter leukocyte telomere length in patients with chronic heart failure. Eur J Heart Fail., 12(4), pp. 348-53.

Mainous AG 3rd, Codd V, Diaz VA, Schoepf UJ, Everett CJ, Player MS, Samani NJ. (2010). Leukocyte telomere length and coronary artery calcification. Atherosclerosis, 210(1), pp. 262-7.

Recent papers

Zierer J, Kastenmüller G, Suhre K, Gieger C, Codd V, Tsai PC, Bell J, Peters A, Strauch K, Schulz H, Weidinger S, Mohney RP, Samani NJ, Spector T, Mangino M, Menni C. 2016. Metabolomics profiling reveals novel markers for leukocyte telomere lengthAging (Albany NY) 8(1): 77-94.

Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL; ENGAGE Consortium Telomere Group, Samani NJ, Wiencke JK, Wrensch MR. 2015. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma riskOncotarget 6(40): 42468-77.

Smeets CC, Codd V, Samani NJ, Hokken-Koelega AC. 2015. Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological AgeingPLoS One 10(11): e0143951.

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD. 2015. The transcriptional landscape of age in human peripheral bloodNat Commun. 6: 8570.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T. 2015. Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurementsInt J Epidemiol. 44(5): 1686-7.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, Van Der Harst P, Bekaert S, De Meyer T, Roos G, Svenson U, Codd V, Samani NJ, Mcglynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, Von Zglinicki T. 2015. Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir ButurovicInt J Epidemiol. 44(5): 1739-41.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T. 2015. Reproducibility of Telomere Length Assessment - An International Collaborative StudyInt J Epidemiol. 44(5): 1749-54.

Strohmaier J, van Dongen J, Willemsen G, Nyholt DR, Zhu G, Codd V, Novakovic B, Hansell N, Wright MJ, Rietschel L, Streit F, Henders AK, Montgomery GW, Samani NJ, Gillespie NA, Hickie IB, Craig JM, Saffery R, Boomsma DI, Rietschel M, Martin NG. 2015. Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life. Twin Res Hum Genet. 18(2): 198-209.

Mangino M, Christiansen L, Stone R, Hunt SC, Horvath K, Eisenberg DT, Kimura M, Petersen I, Kark JD, Herbig U, Reiner AP, Benetos A, Codd V, Nyholt DR, Sinnreich R, Christensen K, Nassar H, Hwang SJ, Levy D, Bataille V, Fitzpatrick AL, Chen W, Berenson GS, Samani NJ, Martin NG, Tishkoff S, Schork NJ, Kyvik KO, Dalgård C, Spector TD, Aviv A. 2015. DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet. 52(3): 157-162.

Martin-Ruiz CM, Baird D, Roger L, Boukamp P, Krunic D, Cawthon R, Dokter MM, van der Harst P, Bekaert S, de Meyer T, Roos G, Svenson U, Codd V, Samani NJ, McGlynn L, Shiels PG, Pooley KA, Dunning AM, Cooper R, Wong A, Kingston A, von Zglinicki T. 2015. Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol. 44(5): 1673-83.

Broer L, Raschenberger J, Deelen J, Mangino M, Codd V, Pietiläinen KH, Albrecht E, Amin N, Beekman M, de Craen AJ, Gieger C, Haun M, Henneman P, Herder C, Hovatta I, Laser A, Kedenko L, Koenig W, Kollerits B, Moilanen E, Oostra BA, Paulweber B, Quaye L, Rissanen A, Roden M, Surakka I, Valdes AM, Vuolteenaho K, Thorand B, van Dijk KW, Kaprio J, Spector TD, Slagboom PE, Samani NJ, Kronenberg F, van Duijn CM, Ladwig KH. 2014. Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. Eur J Epidemiol. 29(9): 629-638.

Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE; ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. 2014. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 46(7): 731-735.

Saxena R, Bjonnes A, Prescott J, Dib P, Natt P, Lane J, Lerner M, Cooper JA, Ye Y, Li KW, Maubaret CG, Codd V, Brackett D, Mirabello L, Kraft P, Dinney CP, Stowell D, Peyton M, Ralhan S, Wander GS, Mehra NK, Salpea KD, Gu J, Wu X, Mangino M, Hunter DJ, De Vivo I, Humphries SE, Samani NJ, Spector TD, Savage SA, Sanghera DK. 2014. A Genome-Wide Association Study Identifies Variants in Casein Kinase II (CSNK2A2) to be Associated with Leukocyte Telomere Length in a Punjabi Sikh Diabetic Cohort. Circ Cardiovasc Genet. 7(3): 287-295.

Deelen J, Beekman M, Codd V, Trompet S, Hägg S, Broer L, Fischer K, Thijssen PE, Suchiman HED, de Craen AJM, Metspalu A, van Duijn CM, Pedersen N, Jukema JW, Samani NJ, Slagboom PE. 2014. Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. Int J Epidemiol. 43(3): 878-886.

Huzen J, Wong LS, van Veldhuisen DJ, Samani NJ, Zwinderman AH, Codd V, Cawthon RM, Benus GF, van der Horst IC, Navis G, Bakker SJ, Gansevoort RT, de Jong PE, Hillege HL, van Gilst WH, de Boer RA, van der Harst P. 2014. Telomere length loss due to smoking and metabolic traits. J Intern Med. 275(2): 155-63.

Albrecht E, Sillanpää E, Karrasch S, Alves AC, Codd V, Hovatta I, Buxton JL, Nelson CP, Broer L, Hägg S, Mangino M, Willemsen G, Surakka I, Ferreira MA, Amin N, Oostra BA, Bäckmand HM, Peltonen M, Sarna S, Rantanen T, Sipilä S, Korhonen T, Madden PA, Gieger C, Jörres RA, Heinrich J, Behr J, Huber RM, Peters A, Strauch K, Wichmann HE, Waldenberger M, Blakemore AI, de Geus EJ, Nyholt DR, Henders AK, Piirilä PL, Rissanen A, Magnusson PK, Viñuela A, Pietiläinen KH, Martin NG, Pedersen NL, Boomsma DI, Spector TD, van Duijn CM, Kaprio J, Samani NJ, Jarvelin MR, Schulz H. 2013. Telomere length in circulating leukocytes is associated with lung function and disease. Eur Respir J. 43(4): 983-992.

Broer L, Codd V, Nyholt DR, Deelen J, Mangino M, Willemsen G, Albrecht E, Amin N, Beekman M, de Geus EJC, Henders A, Nelson CP, Steves CJ, Wright MJ, de Craen AJM, Isaacs A, Matthews M, Moayyeri A, Montgomery GW, Oostra BA, Vink JM, Spector TD, Slagboom PE, Martin NG, Samani NJ, van Duijn CM, Boomsma DI. 2013. Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet. 21(10): 1163-8.

Denham J, Nelson CP, O'Brien BJ, Nankervis SA, Denniff M, Harvey JT, Marques FZ, Codd V, Zukowska-Szczechowska E, Samani NJ, Tomaszewski M, Charchar FJ. 2013. Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors. PLoS One. 31;8(7): e69377.

Ladwig KH, Brockhaus AC, Baumert J, Lukaschek K, Emeny R, Kruse J, Häfner S, Albrecht E, Illig T, Codd V,  Samani NJ, Wichmann HE, Gieger C, Peters A. 2013. Telomere shortening in posttraumatic stress disorder. Findings from 3,000 participants in the population-based KORA F4 study. PLoS One 3;8(7): e64762.

Codd V, Nelson CP, Albrecht E, Mangino M et al. 2012. Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics 45(4): 422-7.

IBC 50K CAD Consortium 2011.  Large scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genetics 7(9): e1002260.

Schunkert H König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I; Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J; CARDIoGRAM Consortium, Samani NJ. 2011. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.  Nature Genetics 43(4): 333-8.

Huzen J, Peeters W, de Boer RA, Moll FL, Wong LS, Codd V, de Kleijn DP, de Smet BJ, Veldhuisen DJ, Samani NJ, van Gilst WH, Pasterkamp G, van der Harst P. 2011. Circulating leukocyte and carotid atherosclerotic plaque telomere length; interrelation, correlation with plaque characteristics, and restenosis after endarterectomy.  Arterioscler Thromb Vasc Biol. 31(5): 1219-25.

Mainous AG 3rd, Everett CJ, Diaz VA, Baker R, Mangino M, Codd V, Samani NJ. 2011. Leukocyte telomere length and marital status among middle-aged adults. Age Ageing 40(1): 73-8.

Tomaszewski M, Debiec R, Braund PS, Nelson CP, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton PR, Mooser V, Charchar FJ, Thompson JR, Tobin MD, Samani NJ. 2010. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension 56(6): 1069-76.

Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M, Beveridge AJ, Rafelt S, Moore J, Nelson C, Soranzo N, Zhai G, Valdes AM, Blackburn H, Mateo Leach I, de Boer RA, Kimura M, Aviv A; Wellcome Trust Case Control Consortium, Goodall AH, Ouwehand W, van Veldhuisen DJ, van Gilst WH, Navis G, Burton PR, Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ. 2010. Common variants near TERC are associated with mean telomere length. Nat Genet. 42(3): 197-9.

Kuznetsova T, Codd V, Brouilette S, Thijs L, Gonzales A, Jin Y, Richart T, van der Harst P, Diez J, Staessen JA, Samani NJ. 2010. Association between Left Ventricular Mass and Telomere Length in a Population Study. Am. J. Epidemiol. 172(4): 440-50.

Diaz VA, Mainous AG 3rd, Everett CJ, Schoepf UJ, Codd V, Samani NJ. 2010. Effect of healthy lifestyle behaviours on the association between leukocyte telomere length and coronary artery calcium. Am J Cardiol. 106(5): 659-63.

Wong LSM, Huzen J , van der Harst P, de Boer RA, Codd V, Westenbrink BD, Benus GFDJ, Voors AA, van Gilst WH, Samani NJ, Jaarsma T, van Veldhuisen DJ. 2010. Anaemia is associated with shorter leukocyte telomere length in patients with chronic heart failure. Eur J Heart Fail 12(4): 348-53.

Mainous AG 3rd, Codd V, Diaz VA, Schoepf UJ, Everett CJ, Player MS, Samani NJ. 2010. Leukocyte telomere length and coronary artery calcification. Atherosclerosis. 210(1): 262-7.

van der Harst P, de Boer RA, Samani NJ, Wong LS, Huzen J, Codd V, Hillege HL, Voors AA, van Gilst WH, Jaarsma T, van Veldhuisen DJ. 2010. Telomere length and outcome in heart failure. Ann Med. 42(1): 36-44.

Wong LS, van der Harst P, de Boer RA, Codd V, Huzen J, Samani NJ, Hillege HL, Voors AA, van Gilst WH, Jaarsma T, van Veldhuisen DJ. 2009.  Renal dysfunction is associated with shorter telomere length in heart failure. Clin Res Cardiol. 98(10): 629-34.

Research

The role of biological ageing in coronary artery disease

We have previously shown that shorter mean leucocyte telomere length (LTL), a marker of increased biological age, is associated with increased risk of coronary artery disease (CAD).  LTL declines with age and on average is longer in women compared to men. LTL also shows high inter-individual variation, even at birth and is a heritable trait. Our recent work has identified some of the genetic variants that are responsible for determining LTL. Using these genetic variants we have subsequently been able to imply that the relationship between shorter LTL and CAD is causal and not due to reverse causation or confounding. However, the mechanism by which telomere length increases cardiovascular risk remains unclear.

My current research is based around:

  • investigating the biological mechanism by which telomere length influences cardiovascular risk
  • how modulating telomere length affects cellular physiology and response to pro-atherogenic stress
  • investigating the relationship between telomere length and other cardiovascular phenotypes and risk factors

Genetic regulation of telomere length in humans

Using a large-scale genome-wide association (GWAS) approach we have identified seven genetic loci that determine LTL in humans. Five of these loci harbour genes with known roles in telomere biology (TERC, TERT, NAF1, OBFC1, RTEL1).  However, for two loci the mechanism by which LTL may be influenced is not obvious.

Current work involves:

  • identification of additional genetic determinants of LTL
  • identification of the functional SNP(s) within each locus and the mechanism by which they impact on gene/protein function and LTL regulation.
  • investigating the biological mechanism by which the Chr2 (ACYP2) and Chr19 (ZNF) influence LTL
  • epigenetic and gene expression changes associated with changes in LTL

Supervision

I am interested in supervising PhD students in the following areas:

  • investigating the biological mechanism by which telomere length influences cardiovascular risk
  • how telomere length affects cellular physiology and stress response
  • genetic regulation of LTL
  • differential regulation of genes and pathways in response to telomere shortening
  • developing additional markers for biological ageing

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