Recent Papers

Recent papers by Professor Nick Brindle , Department of Cardiovascular Sciences, University of Leicester

Fischer M, Kang M, Brindle NP. 2016. Using experimental evolution to probe molecular mechanisms of protein function. Protein Sci. 25(2): 352-9.

Tahir TA, Singh H, Brindle NP. 2014. The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1. Cell Signal. 26(7): 1379-84.

Brindle, N. P., Sale, J. E., Arakawa, H., Buerstedde, J. M., Nuamchit, T., Sharma, S., and Steele, K. H. 2013. Directed evolution of an Angiopoietin-2 ligand trap by somatic hypermutation and cell surface display. Journal of Biological Chemistry 288: 33205-33212.

Singh, H., Hansen, T. M., Patel, N., & Brindle, N. P. J. 2012. The Molecular Balance between Receptor Tyrosine Kinases Tie1 and Tie2 Is Dynamically Controlled by VEGF and TNF alpha and Regulates Angiopoietin Signalling. PLOS ONE, 7(1).

Singh, H., Tahir, T. A., Alawo, D. O. A., Issa, E., & Brindle, N. P. J. 2011. Molecular control of angiopoietin signalling. Biochem. Soc. Trans. 39: 1592-1596.

Kopp PM, Bate N, Hansen TM, Brindle NP, Praekelt U, Debrand E, Coleman S, Mazzeo D, Goult BT, Gingras AR, Pritchard CA, Critchley DR, Monkley SJ. 2010. Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1Eur J Cell Biol. 89(9): 661-73.

Singh H, Brindle NP, Zammit VA. 2010. High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1Microvasc Res. 79(2): 121-127.

Hansen TM, Singh H, Tahir TA, Brindle NP. 2010. Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cell Signal. 22(3): 527-32.

Moss AJ, Sharma S, Brindle NP. 2009. Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering. Biochem Soc Trans. 37(Pt4): 717-21.

Singh H, Milner CS, Aguilar Hernandez MM, Patel N, Brindle NP. 2009. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cell Signal. 21(8): 1346-50.

Milner CS, Hansen TM, Singh H, Brindle NP. 2009. Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. Microvasc Res. 77(2): 187-91.

Hansen TM, Moss AJ, Brindle NP. 2008. Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke. Curr Neurovasc Res. 5(4): 235-44.

Milner CS, Hansen TM, Singh H, Brindle NP. 2009. Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. Microvasc Res. 77(2): 187-91.

Rees KA, Singh H, Brindle NP. 2007. The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines. Int J Oncol. 31(4): 893-7.

Marron MB, Singh H, Tahir TA, Kavumkal J, Kim HZ, Koh GY, Brindle NP. 2007. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem. 282(42): 30509-17.

Dunmore BJ, McCarthy MJ, Naylor AR, Brindle NP. 2007. Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. J Vasc Surg. 45(1): 155-9.

Morris PN, Dunmore BJ, Brindle NP. 2006. Mutant Tie2 causing venous malformation signals through Shc. Biochem Biophys Res Commun. 346(1): 335-8.

Brindle NP, Saharinen P, Alitalo K. 2006. Signaling and functions of angiopoietin-1 in vascular protection. Circ Res. 98(8): 1014-23.

Gill KA, Brindle NP. 2005. Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium. Biochem Biophys Res Commun. 336(2): 392-6.

Saharinen P, Kerkelä K, Ekman N, Marron M, Brindle N, Lee GM, Augustin H, Koh GY, Alitalo K. 2005. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol. 169(2): 239-43.

Morris PN, Dunmore BJ, Tadros A, Marchuk DA, Darland DC, D'Amore PA, Brindle NP. 2005. Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations. J Mol Med. 83(1): 58-63.

Clover AJ, McCarthy MJ, Hodgkinson K, Bell PR, Brindle NP. 2003. Noninvasive augmentation of microvessel number in patients with peripheral vascular disease. J Vasc Surg. 38(6): 1309-12.

Tadros A, Hughes DP, Dunmore BJ, Brindle NP. 2003. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. Blood. 102(13): 4407-9.

Hughes DP, Marron MB, Brindle NP. 2003. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Circ Res. 92(6): 630-6.

Tsiamis AC, Morris PN, Marron MB, Brindle NP. 2002. Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex. Microvasc Res. 63(2): 149-58.

Cotton JM, Thomas MR, Dunmore BJ, Salisbury J, Shah AM, Brindle NP. 2002. Angiogenesis in chronically ischaemic human heart following percutaneous myocardial revascularisation. Heart. 87(3): 281-3.

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