Professor Matt Bown

portrait2Professor of Vascular Surgery

Department of Cardiovascular Sciences

University of Leicester
BHF Cardiovascular Research Centre
Glenfield General Hospital
Leicester, LE2 7LX

Tel: +44 (0)116 252 3190
Email: m.bown@le.ac.uk

 

Personal details

  • MB BCh - University of Wales College of Medicine - 1997
  • MD - University of Leicester - 2003
  • FRCS - The Royal College of Surgeons of England - 2008
  • PGCert (Bioinformatics) - Oxford University - 2009

I was initially appointed as a Clinical Lecturer in 2003 and, following the award of my CCT and a HEFCE Clinical Senior Lecturer Fellowship, was appointed as a Senior Lecturer in 2010. In 2016, I was promoted to the position of Professor of Vascular Surgery.

 

Appointments

  • Honorary Consultant Vascular Surgeon, University Hospitals of Leicester NHS Trust
  • Director of Clinical Academic Training, University of Leicester
  • Member of national Integrated Academic Training Advisory Committee
  • Member of Council, Society for Academic and Research Surgery (SARS)
  • NIHR Doctoral Research Fellowship panel member

 

Research

 

To find out more about the research carried out by the Leicester Vascular Surgeons in an easy to read format click here.

 

The UK Aneurysm Growth Study

The main focus of my current research is the British Heart Foundation UK Aneurysm Growth Study. More information can be found on the project page here or on the British Heart Foundation website here. We are looking for men with abdominal aortic aneurysms (AAA) to join this research programme. If you have had an aneurysm diagnosed in one of the UK NHS aneurysm screening programmes you can find out more information on how to join the study on the dedicated project page.

 

Other Research Interests

I run a continuing research programme investigating the pathogenesis and clinical management of abdominal aortic aneurysms (AAA).

My laboratory research mainly involves genomic studies of AAA and to date we have identified the majority of the genes that are known to be associated with AAA. My clinical research is focused on the management of early-stage aneurysmal disease including screening.

With previous funding from the Circulation Foundation, and now the British Heart Foundation, I have set up the UK Aneurysm Growth Study, a large prospective cohort study of men with small AAA. This resource will be used to identify clinical and biological factors associated with the growth of AAA and bring together my previous laboratory research with my current clinical research.

I provided clinical input for the NIHR HTA project, 'RESCAN'. Through the analysis of over 15,000 individual AAA patient datasets we were able to identify that lengthening the intervals between AAA surveillance scans was feasible whilst remaining clinically effective at preventing AAA rupture. These new surveillance intervals are currently under consideration by the NHS AAA Screening Programme and the primary results of this project were published in JAMA (2013).

I am recently finished working with colleagues from Cambridge, Brunel and Imperial College on an NIHR HTA funded project 'Screening Women for Abdominal Aortic Aneurysms (SWAN)' to construct an economic model for AAA screening in women. In 2016 I obtained funding from the NIHR to conduct a pilot study of AAA screening in women, the 'Female Aneurysm screening STudy (FAST)'. Together, these two projects will help the NHS decide whether to screen women for AAAs.

 

Funding sources

The Wellcome Trust

The Dunhill Medical Trust

The Circulation Foundation

The British Heart Foundation

NIHR

Training

Academic Vascular Surgery Training

 
Opportunities for training in academic vascular surgery in Leicester (ACF, ACL, Research Fellows, Lecturers)

In Leicester we have a strong track record in training academic vascular surgeons. We have an active cohort of junior surgeons pursuing post-graduate studies (MD or PhD) and regularly support Academic Clinical Fellows (ACF) and Academic Clinical Lecturers (ACL). Anyone interested in exploring these opportunities should contact Professor Matt Bown in the first instance.

Publications

Bibliometrics: 138 peer-reviewed publications, h-index 32, 2785 citations

Key papers: 

 

Jones GT,……, Bown MJ (2017). Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circ Res 120(2):341-353.

Bath MF, Saratzis A, Saedon M, Sidloff D, Sayers R, Bown MJ, UKAGS investigators (2017). Patients with Small Abdominal Aortic Aneurysm are at Significant Risk of Cardiovascular Events and this Risk is not Addressed Sufficiently. Eur J Vasc Endovasc Surg, 53(2):255-260.

Desai M, Choke E, Sayers RD, Nath M, Bown MJ (2016). Sex-related trends in mortality after elective abdominal aortic aneurysm surgery between 2002 and 2013 at National Health Service hospitals in England: less benefit for women compared with men. Eur Heart J, 7;37(46):3452-3460.

Jones GT, Bown MJ, Gretarsdottir S, Romaine SP, Helgadottir A, Yu G,……, van Rij AM. (2013). A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet, 22(14), 2941-2947.

Bradley DT, Hughes AE, Badger SA, Jones GT, Harrison SC, Wright BJ,……, Bown MJ. (2013). A variant in LDLR is associated with abdominal aortic aneurysm. Circ Cardiovasc Genet, 6(5), 498-504.

Stather PW, Sylvius N, Wild JB, Choke E, Sayers RD, Bown MJ. (2013). Differential microRNA expression profiles in peripheral arterial disease. Circ Cardiovasc Genet, 6(5), 490-497.

Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ,……, Humphries SE. (2013). Interleukin-6 receptor pathways in abdominal aortic aneurysm. Eur Heart J, 34(48), 3707-3716.

Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ,    Powell JT. (2013). Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: Implications for surveillance intervals and their cost-effectiveness. Health Technol Assess, 17(41).

RESCAN Collaborators: Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SG. (2013). Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis. JAMA, 309(8), 806-813.

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF,    Samani NJ. (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet, 89(5), 619-627.

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