Dr David Adlam

Personal details

  • Associate Professor in acute and interventional cardiology, honorary consultant
  • +44 (0)116 204 4751
  • da134@le.ac.uk

 

I am an interventional cardiologist with practice in coronary stenting and TAVI valve implantation. Working within the Leicester NIHR Biomedical Research Centre, my research interests include:

  • Rare cardiovascular diseases including spontaneous coronary artery dissection (SCAD), coronary aneurysms and ectasia (CAE) and fibromuscular dysplasia (FMD)
  • Novel medical devices
  • Big data linkage to better understand disease interactions and comorbidity
  • Diagnosis and management of coronary artery diseases and acute myocardial infarction

 

Qualifications

  • BA BM BCh DPhil FRCP FESC

 

Teaching and Research Supervision

Candidates considering applications for PhD, MD, ACF and ACL positions should contact me directly on the above email..

 

Research

Selected research studies

Spontaneous Coronary Artery Dissection (SCAD): I lead the UK SCAD study currently supported by the patient charity BeatSCAD. I also chair the ESC-EORP SCAD registry.

The Virtual Cardio-oncology research initiative (VICORI); I am the joint lead investigator for this national data linkage initiative to connect cardiovascular and cancer data in order to better understand the interrelationship between the two commonest caused of morbidity and mortality in the UK.

 

Current Patents

Cardiac assist device: EP3277337A1

The PAL-VAD device is a novel left ventricular assist device being developed with support from the British Heart Foundation

Angioplasty of calcified arteries: PCT/GB2017/050877

The Lithocatheter device is a novel angioplasty device targeting calcified coronary arteries and being developed with support of the MRC

 

Awards and Nominations

  • 2018 - Paul Dudley White International Scholar Award Highest Ranked Abstract  from the United Kingdom at Scientific Sessions 2018
  • 2017 – BHF Heart Hero Award
  • 2017 - Exceptional PPIE Engagement CRN E Mids Award
  • 2003 - Wellcome Trust Junior Research Fellowship
  • 1992-1998 – Scholarship of Christ Church Oxford

 

External Roles

National institute for cardiovascular outcome research (NICOR) research steering group

Co-chair. ESC-ACVC SCAD study group

Scientific Advisory Board - SCAD Alliance

 

Media

https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/future-of-lvads

https://www.theengineer.co.uk/heart-pump-lvad-leicester/

http://www.bbc.co.uk/news/uk-39106357

http://www.itv.com/news/2016-02-29/new-trial-into-potentially-deadly-condition-that-affects-otherwise-healthy-women/

http://bit.ly/2mCDkt6

 

Publications

Selected publications

Margaritis M, Saini F, Baranowska-Clarke AA, Parsons S, Vink A, Budgeon C, Alcock N, Wagner BE, Samani NJ, von der Thüsen J, Robertus JL, Sheppard MN, Adlam D. Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications. Cardiovasc Res. 2021 May 28:cvab183. doi: 10.1093/cvr/cvab183. Online ahead of print.PMID: 34048532

Kotecha D, Garcia-Guimaraes M, Premawardhana D, Pellegrini D, Oliver-Williams C, Boutziouka V, Wood A, Natarajan N, Jackson R, Chan N, Ziaullah J, Rakhit RD, Hoole SP, Johnson TW, Kadziela J, Ludman P, Samani NJ, Maas AHEM, van Geuns RJ, Alfonso F, Adlam D. Risks and benefits of percutaneous coronary intervention in spontaneous coronary artery dissection. Heart. 2021 May 18:heartjnl-2020-318914. doi: 10.1136/heartjnl-2020-318914. Online ahead of print.PMID: 34006503

Carss KJ, Baranowska AA, Armisen J, Webb TR, Hamby SE, Premawardhana D, Al-Hussaini A, Wood A, Wang Q, Deevi SVV, Vitsios  D, Lewis SH, Kotecha D, Bouatia-Naji N, Hesselson S, Iismaa SE, Tarr I, McGrath-Cadell L, Muller DW, Dunwoodie SL, Fatkin D, Graham RM, Giannoulatou E, Samani NJ, Petrovski S, Haefliger C, Adlam D. Spontaneous Coronary Artery Dissection: Insights on rare genetic variation from genome sequencing. Circ Genom Precis Med. 2020 Dec;13(6):e003030. doi: 10.1161/CIRCGEN.120.003030. Epub 2020 Oct 30.PMID: 33125268

Hayes SN, Tweet MS, Adlam D, Kim ESH, Gulati R, Price JE, Rose CH. .Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Aug 25;76(8):961-984. doi: 10.1016/j.jacc.2020.05.084

Verstraeten A, Perik MHAM, Baranowska AA, Meester JAN, Van Den Heuvel, Bastianen LJ, Kempers M, Krapels IPC, Maas A, Rideout A, Vandersteen A, Sobey G, Johnson D, Fransen E, Ghali N, Webb T, Al-Hussaini A, de Leeuw P, Delmotte P, Lopez-Sublet M, Pappaccogli MM, Sprynger M, Toubiana L, the European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI), Van Laer L, Van Dijk FS, Vikkula M, Samani NJ, Persu A,#, Adlam D,#, Loeys B,# Enrichment of rare variants in Loeys-Dietz syndrome genes in spontaneous coronary artery dissection but not in severe fibromuscular dysplasia. Circulation. 2020 Sep 8;142(10):1021-1024. doi: 10.1161/CIRCULATIONAHA.120.045946. Epub 2020 Sep 8.

Wright JR, Chauhan M, Shah C, Ring A, Thomas AL, Goodall AH, Adlam D. The TICONC (Ticagrelor-Oncology) Study. Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis. J Am Coll Cardiol CardioOncol. 2020 Jun, 2 (2) 236-250

Al-Hussaini A, Abdelaty AMSEK, Gulsin GS, Arnold JR, Garcia-Guimaraes M, Premawardhana D, Budgeon C, Wood A, Natarajan N, Mangion K, Rakhit R, Hoole SP, Johnson TW, Berry C, Hudson I, Gershlick AH, Ladwiniec A, Kovac J, Squire I, Samani NJ, Plein S, McCann GP, Adlam D. Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. Eur Heart J. 2020 Jun 14;41(23):2197-2205. doi: 10.1093/eurheartj/ehz895.Eur Heart J. 2020.PMID: 31898721

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d'Escamard V, Huang S, Margaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewicz S, Jeunemaitre X; DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X; CARDIoGRAMPlusC4D Study Group, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.

Adlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Feb 22. doi: 10.1093/eurheartj/ehy080. [Epub ahead of print] No abstract available.

Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22. Review.

 

Book Chapters

Adlam D, Alfonso F, Mass A, Persu A, Vrints C. Spontaneous Coronary Artery Dissection. Chapter in; The PCR – EAPCI Textbook. Percutaneous Interventional Cardiovascular Medicine. Eds. De Palma R, Capranzano P.

Adlam D. The ECG in Practice 5th and 6th and 7th Editions. Ed. Hampton JR. Elsevier Ltd. 2008, 2015, 2019 (winner of the BMJ book award (cardiology) 2009 and 150 ECG Cases 5th Edition 2019

Adlam D, Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S, Curzon N, Redwood M. Oxford University Press 2010 and 2nd Edition 2018

Adlam D, Adnan A. Coronary artery disease and acute coronary syndrome. Chapter in ABC of arterial and venous diseases Wiley 2014

Adlam D, Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010, 2015 and 2018

Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011

Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P, Sprigings D. Oxford University press 2010

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