Dr David Adlam

Personal details

  • Associate Professor in acute and interventional cardiology, honorary consultant
  • +44 (0)116 204 4751
  • da134@le.ac.uk

 

I am an interventional cardiologist with practice in coronary stenting and TAVI valve implantation. Working within the Leicester NIHR Biomedical Research Centre, my research interests include:

  • Rare cardiovascular diseases including spontaneous coronary artery dissection (SCAD), coronary aneurysms and ectasia (CAE) and fibromuscular dysplasia (FMD)
  • Novel medical devices
  • Big data linkage to better understand disease interactions and comorbidity
  • Diagnosis and management of coronary artery diseases and acute myocardial infarction

 

Qualifications

  • BA BM BCh DPhil FRCP FESC

 

Teaching

  • I have a number of PhD and MD students and have also enjoyed working with academic foundation students and academic clinical fellows. I also support clinical teaching of medical students and training grade doctors as part of my clinical work.

 

Research

Selected research studies

Spontaneous Coronary Artery Dissection (SCAD): I lead the UK SCAD study currently supported by the patient charity BeatSCAD. I also chair the ESC-EORP SCAD registry.

The Virtual Cardio-oncology research initiative (VICORI); I am the joint lead investigator for this national data linkage initiative to connect cardiovascular and cancer data in order to better understand the interrelationship between the two commonest caused of morbidity and mortality in the UK.

 

Current Patents

Cardiac assist device: EP3277337A1

The PAL-VAD device is a novel left ventricular assist device being developed with support from the British Heart Foundation

Angioplasty of calcified arteries: PCT/GB2017/050877

The Lithocatheter device is a novel angioplasty device targeting calcified coronary arteries and being developed with support of the MRC

 

Awards and Nominations

  • 2018 - Paul Dudley White International Scholar Award Highest Ranked Abstract  from the United Kingdom at Scientific Sessions 2018
  • 2017 – BHF Heart Hero Award
  • 2017 - Exceptional PPIE Engagement CRN E Mids Award
  • 2003 - Wellcome Trust Junior Research Fellowship
  • 1992-1998 – Scholarship of Christ Church Oxford

 

External Roles

National institute for cardiovascular outcome research (NICOR) research steering group

Co-chair. ACCA-ESC SCAD study group

Scientific Advisory Board - SCAD Alliance

 

Editorial Board and Reviewer Experience

European Heart Journal: Acute Cardiovascular Care Editorial Board

Reviewer for multiple cardiovascular journals

 

Periodic Reviewer and External Examiner Experience

  • External examiner for University of Sheffield BmedSci

 

Research Supervision

Current supervisor of PhD and MD students, academic foundation and ACF students

 

Media

https://www.bhf.org.uk/informationsupport/heart-matters-magazine/research/future-of-lvads

https://www.theengineer.co.uk/heart-pump-lvad-leicester/

http://www.bbc.co.uk/news/uk-39106357

http://www.itv.com/news/2016-02-29/new-trial-into-potentially-deadly-condition-that-affects-otherwise-healthy-women/

http://bit.ly/2mCDkt6

 

Publications

Selected publications from 2005

Jackson R, Al-Hussaini A, Joseph S, van Soest G, Wood A, Macaya F, Gonzalo N, Cade J, Caixeta A, Hlinomaz O, Leinveber P, O'Kane P, García-Guimaraes M, Cortese B, Samani NJ, Escaned J, Alfonso F, Johnson T, Adlam D. Spontaneous Coronary Artery Dissection: Pathophysiological Insights From Optical Coherence Tomography. JACC Cardiovasc Imaging. 2019 Mar 8. pii: S1936-878X(19)30145-7. doi: 10.1016/j.jcmg.2019.01.015. [Epub ahead of print]

Ciurică S, Lopez-Sublet M, Loeys BL, Radhouani I, Natarajan N, Vikkula M, Maas AHEM, Adlam D, Persu A. Arterial Tortuosity. Hypertension. 2019 May;73(5):951-960. doi: 10.1161/HYPERTENSIONAHA.118.11647. No abstract available.

Adlam D, García-Guimaraes M, Maas AHEM. Spontaneous coronary artery dissection: no longer a rare disease. Eur Heart J. 2019 Apr 14;40(15):1198-1201. doi: 10.1093/eurheartj/ehz048. No abstract available.

Gornik Co-Chair HL, Persu Co-Chair A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, de Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ES, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF. First International Consensus on the diagnosis and management of fibromuscular dysplasia. Vasc Med. 2019 Jan 16:1358863X18821816. doi: 10.1177/1358863X18821816.

Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, De Leeuw P, Fendrikova-Mahlay N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ESH, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touzé E, Van der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF; Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). First international consensus on the diagnosis and management of fibromuscular dysplasia. J Hypertens. 2019 Feb;37(2):229-252. doi: 10.1097/HJH.0000000000002019.

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d'Escamard V, Huang S, Margaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewicz S, Jeunemaitre X; DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X; CARDIoGRAMPlusC4D Study Group, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019 Jan 8;73(1):58-66. doi: 10.1016/j.jacc.2018.09.085.

Maas AHEM, Bouatia-Naji N, Persu A, Adlam D. Spontaneous coronary artery dissections and fibromuscular dysplasia: Current insights on pathophysiology, sex and gender. Int J Cardiol. 2018 Nov 9. pii: S0167-5273(18)34907-6. doi: 10.1016/j.ijcard.2018.11.023. [Epub ahead of print]

Macaya F, Salinas P, Gonzalo N, Camacho-Freire SJ, Jackson R, Massot M, Ortas-Nadal MR, Sánchez-Recalde Á, Díaz-Fernández JF, Moreu J, Adlam D, Escaned J. Long-term follow-up of spontaneous coronary artery dissection treated with bioresorbable scaffolds. EuroIntervention. 2019 Jan 20;14(13):1403-1405. doi: 10.4244/EIJ-D-18-00519. No abstract available.

Adlam D, Alfonso F, Maas A, Vrints C; Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur Heart J. 2018 Feb 22. doi: 10.1093/eurheartj/ehy080. [Epub ahead of print] No abstract available.

Hayes SN, Kim ESH, Saw J, Adlam D, Arslanian-Engoren C, Economy KE, Ganesh SK, Gulati R, Lindsay ME, Mieres JH, Naderi S, Shah S, Thaler DE, Tweet MS, Wood MJ; American Heart Association Council on Peripheral Vascular Disease; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Genomic and Precision Medicine; and Stroke Council. Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association. Circulation. 2018 May 8;137(19):e523-e557. doi: 10.1161/CIR.0000000000000564. Epub 2018 Feb 22. Review.

Adlam D, Wood A, Al-Hussaini A. Editorial on "Characteristics of extension and de novo recurrent spontaneous coronary artery dissection". EuroIntervention. 2017 Dec 8;13(12):e1381-e1383.

Adlam D, Peake MD. Cancer and heart disease: new bedfellows in the cardiovascular landscape. Eur Heart J Qual Care Clin Outcomes. 2017 Jul 1;3(3):168-170.

Waterhouse BR, Tulloh RMR, Kim Y, Creasy W, Adlam D, Johnson TW. Retrospective study of the impact of unrecognised Kawasaki disease, coronary aneurysm and ectasia. Int J Cardiol. 2017 Aug 10. pii: S0167-5273(17)31526-7.

Cheshire EC, Malcomson RD, Joseph S, Adnan A, Adlam D, Rutty GN. Post-mortem imaging of the infant and perinatal dura mater and superior sagittal sinus using optical coherence tomography. Int J Legal Med. 2017 Apr 7

Al-Hussaini A, Adlam D. Spontaneous coronary artery dissection. Heart. 2017 Jul;103(13):1043-1051.

Joseph S, Adnan A, Adlam D. Automatic segmentation of coronary morphology using transmittance-based lumen intensity-enhanced intravascular optical coherence tomography images and applying a localized level-set-based active contour method. J Med Imaging (Bellingham). 2016 Oct;3(4):044001. Epub 2016 Nov 29.

Adlam D, Maas A, Vrints C, Alfonso F. Spontaneous coronary artery dissection. Eur Heart J. 2016 Oct 21;37(40):3073-3074.

Jackson R, Brennan S, Fielding P, Sims MW, Challiss RA, Adlam D, Squire IB, Rainbow RD. Distinct and complementary roles for α and β isoenzymes of protein kinase C in mediating vasoconstrictor responses to acutely elevated glucose. Br J Pharmacol. 2016 Mar;173(5):870-87.

Cheshire EC, Malcomson RD, Joseph S, Biggs MJ, Adlam D, Rutty GN. Optical clearing of the dura mater using glycerol: a reversible process to aid the post-mortem investigation of infant head injury. Forensic Sci Med Pathol. 2015 Sep;11(3):395-404.

Joseph S, Adnan A, Subhash HM, Leahy M, Adlam D. Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systems. Biomed Opt Express. 2015 Feb 3;6(3):668-89.

Joseph S, Rousseau C, Subhash H. M, Leahy M. J, and Adlam D. Variation in cross-correlation as a discriminator for microvessel imaging using clinical intravascular optical coherence tomography systems. Proc.SPIE 8934, 89342L (2014).

Iqbal J, Fay R, Adlam D, Squire I, Parviz Y, Gunn J, Pitt B, Zannad F. Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial. Eur J Heart Fail. 2014 Jun;16(6):685-91

Morgan B, Adlam D, Robinson C, Pakkal M, Rutty GN. Adult post-mortem imaging in traumatic and cardio-respiratory death and its relation to clinical radiological imaging. Br J Radiol. 2014 Jan 6.

Adlam D, Joseph S, Robinson C, Rousseau C, Barber J, Biggs M, Morgan B, Rutty G. Coronary optical coherence tomography: minimally invasive virtual histology as part of targeted post-mortem computed tomography angiography. Int J Legal Med 2013 Sep;127(5):991-6

Lee R, Adlam D, Antoniades C, Digby JE, Kharbanda RK, Choudhury RP, Channon KM. Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9. Int J Cardiol. 2013 Feb 20;163(2):212-3

Adlam D, Evans N, Malhotra A, Miglani D, Rowley F, Hutchings D, Shin M, Mole G, Stockenhuber A, Wordsworth J, Lumb M, Forfar C. Repeat Percutaneous Coronary Revascularisation: Indications and Outcomes in a ‘Real World’ Cohort. Catheter Cardiovasc Interv. 2012 Oct 1;80(4):539-45

Adlam D, Herring N, Douglas G, De Bono, JP, Li D, Danson EJ, Tatham A, Lu C-J, Casadei B, Paterson DJ, Channon KM. Regulation of β-Adrenergic Control of Heart Rate by GTP-Cyclohydrolase 1 (GCH1) and Tetrahydrobiopterin. Cardiovasc Res. 2012 Mar 15;93(4):694-701

Adlam D, Antoniades C, Lee R, Diesch J, Shirodaria C, Taggart D, Leeson P, Channon KM. Optical coherence tomography characteristics of saphenous vein graft atherosclerosis. JACC imag 2011 Jul;4(7): 807-809

Adlam D*, De Bono JP*, Danson E, Zhang M, Casadei B, Paterson DJ, Channon KM. Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models. Exp Physiol. 2011 Nov;96(11):1118-28.

Inglis RG, King AJ, Gleave M, Bradlow W, Adlam D. Pericardiocentesis in contemporary practice: a study of complications by route of approach. J Invasive Cardiol. 2011 Jun;23(6):234-9.

Adlam D, Hutchings D, Channon KM. Fourier domain Optical Coherence Tomography guided stenting of a large coronary aneurysm: images at implantation and 6-month follow-up. J Invasive Cardiol. 2011 Apr;23(4):168-9

Adlam D, Channon KM. Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography. JACC Cardiovasc Interv. 2011 May;4(5):586-7

Karia N, Adlam D, Dhunnookchand R, Sabharwal. 3-Dimensional transoesophageal echocardiography of an aberrant chordae tendinae causing aortic valvular regurgitation. Eur Heart J. 2011 Apr;32(8):1038

Adlam D, Cuculi F, Lim C, Banning A. Management of spontaneous coronary artery dissection in the primary percutaneous coronary intervention era. J Invasive Cardiol. 2010 Nov;22(11):549-53

Adlam D, Ayers R, Channon KM. Intimal dissection causing late thrombosis of a covered stent: Optical coherence tomography. Circulation Cardiovasc Intervent 2009;2:359-60

Bendall, JK, Rinze, R, Adlam, D, Tatham, AL, de Bono, J and Channon, KM Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 2007 100(7): 1016-25

Adlam D*, Bendall J*, De Bono JP*, Alp NJ, Yokoyama M, Kawashima S, Channon KM. Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP Cyclohydrolase I double transgenic mice. Exp Physiol 2007 Jan;92(1):119-26 (*Joint first authors)

De Bono JP*, Adlam D*, Paterson DJ, Channon KM. Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol 2006 Apr;290(4):R926-34. (*Joint first authors)

Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM.  Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo.  Insights  from transgenic mice with endothelial-targeted GTPCH and eNOS overexpression.  Circ Res 2005 Oct 28;97(9):864-71

Adlam D, Silcocks P, Sparrow N. Using BNP to develop a risk score for heart failure in primary care.  Eur Heart J 2005;26:1086-1093

Azeem T, Adlam D, Gershlick A. Evolution of vascular brachytherapy: data from the RENO-registry analysis.  Int J Cardiol 2005;100(2):225-8

Adlam D, Azeem T, Ali T, Gershlick A. Is there a role for provocation testing to diagnose coronary artery spasm?  Int J Cardiol 2005 ;102(1):1-7

 

Book Chapters and Proposals

Adlam D, Adnan A. Coronary artery disease and acute coronary syndrome. Chapter in ABC of arterial and venous diseases Wiley 2014

Adlam D, Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S, Curzon N, Redwood M. Oxford University Press 2010

Adlam D, Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010, 2015 and 2018

Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011

Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P, Sprigings D. Oxford University press 2010

Adlam D. The ECG in Practice 5th – 7th Ed. 150 ECG cases 5th Ed. with Hampton JR. Elsevier Ltd. 2008 to 2019 (winner of the BMJ book award (cardiology) 2009.

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