Professor Simon Wagner

Academic Champion in Haematology

Professor Simon Wagner

Department of Haematology
2nd Floor
Sandringham Building
Leicester Royal Infirmary

Email: sw227@le.ac.uk  

Biography

Professor Wagner qualified in medicine at St. George’s Hospital, London. He trained in Haematology at St. Bartholomew’s Hospital and the Hammersmith Hospital. His research career started when he was awarded an MRC Training Fellowship, which allowed him to work at the Hammersmith Hospital on leukaemia and obtain a PhD. He followed this with further stints of bench work at the MRC Laboratory of Molecular Biology and the Wellcome Trust Immunology Unit, the latter supported by a Royal Society Fellowship, and both being held in the University of Cambridge. For the past 14 years he has been able to combine clinical work, seeing patients with lymphoma, with running a research laboratory firstly at Imperial College London and since 2008 at the University of Leicester.

At Leicester he has established the Lymphoid Malignancies Group. Professor Wagner has a long-standing interest in understanding the function of the microenvironment in chronic lymphocytic leukaemia (CLL). Currently projects are running to determine novel biomarkers in CLL and the role of T-cells in the microenvironment of CLL and low-grade B-cell lymphomas. The laboratory is also investigating a novel therapeutic target in diffuse large B-cell lymphoma. Over the past 4 years we have established a national presence in the field of T-cell lymphomas. Together with the Haematological Malignancies Biobank at the University of Liverpool we are establishing a Peripheral T-cell Lymphoma (PTCL) Biobank. We also hope to start a clinical trial employing a checkpoint inhibitor antibody in PTCL. Laboratory projects focus on understanding the pathobiology of a new category of PTCL, follicular helper T-cell (Tfh) lymphoma and characterising the effects of small molecule inhibitors that are potential therapeutic agents in this challenging clinical area. Earlier this year Professor Wagner with the Leicester was awarded a GlaxoSmithKline Discovery Partnership with Academia (DPAc) to lead a major collaborative drug discovery project in lymphoma.

Professor Wagner has supervised PhD and MSc students and undergraduate student projects. He has recruited ACL and ACF posts to Haematology. His laboratory work has been funded by Bloodwise, the Kay Kendall Leukaemia Fund, the Leicester Haematology Research Fund and the MRC.

 

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Contact Details

College of Life Sciences
University of Leicester
Maurice Shock Building
University Road
Leicester
LE1 7RH