Genome Diversity and Dynamics

Sub-theme

Fundamental mechanisms and dynamics of mutation and recombination and their outcomes for genetic diversity from bacteria to humans

Alec Jeffreys’ pioneering work on minisatellites, evolving into studies of fundamental molecular processes of normal and abnormal recombination in humans, lies at the root of Leicester’s internationally recognised strength in this area. Colleagues study meiotic crossover and gene conversion processes, copy number variation and the mechanisms that give rise to it, the dynamics of transposable elements, and the influence of environmental factors including ionising radiation and chemical mutagens (Richard BadgeTony Brookes, Yuri Dubrova, James HigginsEd Hollox, Alec Jeffreys, Mark Jobling, Ed LouisCelia May), as well as telomere dynamics (Nicola Royle) and somatic rearrangements giving rise to cancer (Martin Dyer). There is well-established research activity in the area of DNA damage in response to endogenous and exogenous factors, the role of DNA repair, and the consequences for genome instability (Mark Evans, Peter Farmer, Steven FosterDon Jones). The organisation and diversity of genomes, with emphasis on the spread of repeat sequences, is studied in a broad range of eukaryotic species (Pat Heslop-Harrison, Trude Schwarzacher), and the study of diversity and dynamics also extends to bacteria (Chris Bayliss, Shaun Heaphy).

Theme members are named within the sub-themes to which they have the closest affiliation; not all sub-theme affiliations are shown.

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College of Life Sciences
University of Leicester
Maurice Shock Building
University Road
Leicester
LE1 7RH