Genes in Health and Disease


Roles of genes and genomes in monogenic, complex and infectious disease, and in maintenance of non-disease states

Variation within the human genome has a wide range of influences on the probability of developing disease, from simple causative heritable mutations to subtle effects on cancer and complex disease susceptibility. Genetic and genomic approaches are being taken to the investigation of a wide range of diseases, and to non-disease states. These include cell-biological and model organism studies of monogenic diseases (Raymond Dalgleish, Flav Giorgini, Irene Gottlob, Sue Shackleton), and biostatistical and association-study approaches to complex disorders (Tony Brookes, Chris Talbot, Ed Hollox, John Thompson, Martin Tobin, Nuala Sheehan), with particular strength in the genetics of cardiovascular disease (Matt Bown, Alison Goodall, Nilesh Samani, Maciej Tomaszewski). Theme members also study genetic aspects of the causes, diagnosis, progression and treatment of cancer (Julian BarwellYuri Dubrova, Martin Dyer, Peter Farmer, Howard Pringle, Catrin Pritchard, Nicola Royle, Jacqui Shaw), and genetic influences on host immune response (Ed Hollox, Cordula Stover). Genetic and genomic analyses of microbial pathogens is another focus, with studies of the genetic regulation of bacterial physiology and pathogenesis (Mike Barer, Chris Bayliss, Shaun Heaphy, Julian Ketley, Julie Morrissey, Marco Oggioni).
Theme members are named within the sub-themes to which they have the closest affiliation; not all sub-theme affiliations are shown.

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