GACT: Genetic Architecture of Complex Traits

Yeast mosaic
Mosaic of S. cerevisiae by Catarina Gadelha
The Centre for Genetic Architecture of Complex Traits (GACT) was established in 2013 to explore and exploit variation in the model organism Saccharomyces cerevisiae (baker's yeast).

Through this research, we will increase our understanding of the genetics of complex traits in S cerevisiae and other organisms, from evolutionary aspects of adaptation in populations to understanding the nature of disease. We will find ways to build tools for use in other systems that will enable us to measure complexity and to understand how this complexity interferes with our understanding of biology. And we will also develop better yeast - improving fermentation and leading to new products.

Based within the College of Life Sciences and the Department of Genetics, GACT will interact with mathematicians, informaticians, genomics researchers, systems and synthetic biologists, and geneticists in a multidisciplinary approach to these complex problems.

The Director of GACT is Professor Ed Louis.

BYG 2018

A great time was had by all. 27-29 June 2018


12 PhDs in Yeast Biotechnology

We are part of the Marie Skłodowska-Curie Actions European Joint Doctoral Programme YEASTDOC. This is a high quality programmes that deliver comprehensive training in many aspects of yeast biotechnology – as well as an exciting research project that includes interaction with industry partners. - see


Group members June 2018

Other possibilities:

Research topics include quantitative trait analysis of a number of phenotypes from basic evolutionarily/environmentally important traits (such as those involved in adaptation to particular niches) to more applied (such as robustness in biofuel processes and fermentation properties). We also are actively studying telomeres and subtelomeres in Saccharomyces yeasts and have an interest in subtelomeres of parasites and pathogens. Informal queries can be made to Ed Louis ( and more information can be found at research degrees in genetics.

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Contact GACT

To contact the Centre for Genetic Architecture of Complex Traits, please email Professor Ed Louis

The postal address is:

GACT, Department of Genetics, University of Leicester, Leicester LE1 7RH, UK

Phone: (+44) 0116 229 7813

Contact Details

College of Life Sciences
University of Leicester
Maurice Shock Building
University Road