Professor Melanie Davies,CBE, MB, ChB, MD, FRCP, FRCGP

Professor Melanie Davies

Professor of Diabetes Medicine

Diabetes Research Centre/Department of Health Sciences

University of Leicester
Leicester General Hospital
Gwendolen Road, Leicester, LE5 4PW

Tel: +44 (0)116 258 6481

For general enquiries, email Denise Robinson on or telephone +44 (0)116 258 6481.

Personal details

I am a clinician with over 25 years experience working as a diabetologist and physician and since 2006, Professor of Diabetes Medicine at the University of Leicester. I am:

  • An NIHR Senior Investigator, one of only a handful in diabetes in the UK
  • Director of a Clinical Trial Unit
  • Director Lead for Division 2 of the Clinical Research Network East Midlands
  • PI on a number of large global studies in the field of diabetes, obesity and cardiovascular disease

I am the global PI on the SCALE Obesity trial, a large multinational study investigating management of obesity with GLP-1 analogue.

In the last three years, I've had more than 180 peer review publications and in the last five years been awarded over £30,000,000 of external reviewed grant funding.

Professional activities

NIHR Senior Investigator Award, 2008/2012



  1. Jones P, Davies MJ, Khunti K, Fong DTP, Webb D. In-shoe pressure thresholds for people with diabetes and neuropathy at risk of ulceration: A systematic review. J Diabetes Complications 2021 Mar;35(3):107815. doi: 10.1016/j.jdiacomp.2020.107815. Epub 2020 Nov 26. Review. PubMed PMID: 33280984.
  2. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group.Once-weekly Semaglutide in Adults with overweight or obesity.N Engl J Med. 2021 Feb 10.Doi: 10.1056/NEJMoa2032183. [Online ahead of print].PMID: 33567185
  3. Ahmad E, Waller HL, Sargeant JA, Webb MA, Htike ZZ, McCann GP, Gulsin G, Khunti K, Yates T, Henson J, Davies MJ, Webb DR. Effects of liraglutide versus sitagliptin on circulating cardiovascular biomarkers, including circulating progenitor cells, in individuals with type 2 diabetes and obesity: Analyses from the LYDIA trial. Diabetes Obes Metab 2021 Feb 10. Doi: 10.1111/dom.14343. [Online ahead of print]. PMID: 33565691
  4. Ling S, Zaccardi F, Lawson C, Seidu SI, Davies MJ, Khunti K. Glucose Control, Sulfonylureas, and Insulin Treatment in Elderly People With Type 2 Diabetes and Risk of Severe Hypoglycemia and Death: An Observational Study. Diabetes Care 2021 Feb 4;. doi: 10.2337/dc20-0876. [Epub ahead of print] PubMed PMID: 33541857.
  5. Coles B, Zaccardi F, Seidu S, Gillies CL, Davies MJ, Hvid C, Khunti K. Rates and estimated cost of primary care consultations in people diagnosed with type 2 diabetes and comorbidities: A retrospective analysis of 8.9 million consultations. Diabetes Obes Metab 2021 Feb 4;. doi: 10.1111/dom.14340. [Epub ahead of print] PubMed PMID: 33539642.
  6. Zaccardi F, Kloecker DE, Buse JB, Mathieu C, Khunti K, Davies MJUse of Metformin and Cardiovascular Effects of New Classes of Glucose-Lowering Agents: A Meta-analysis of Cardiovascular Outcome Trials in Type 2 Diabetes. Diabetes Care 2021 Feb;44(2):e32-e34. doi: 10.2337/dc20-2080. Epub 2020 Dec 17. PubMed PMID: 33334809.
  7. Inzucchi SE, Davies MJ, Khunti K, Trivedi P, George JT, Zwiener I, Johansen OE, Sattar N. Empagliflozin treatment effects across categories of baseline HbA1c, body weight and blood pressure as an add-on to metformin in patients with type 2 diabetes. Diabetes Obes Metab 2021 Feb;23(2):425-433. doi: 10.1111/dom.14234. Epub 2020 Nov 20. PubMed PMID: 33084149; PubMed Central PMCID: PMC7839733.
  8. Harrington DM, Brady EM, Weihrauch-Bluher S, Edwardson CL, Gray LJ, Hadjiconstantinou M, Jarvis J, Khunti K, Vergara I, Erreguerena I, Ribeiro RT, Troughton J, Vazeou A, Davies MJDevelopment of an Interactive Lifestyle Programme for Adolescents at Risk of Developing Type 2 Diabetes: PRE-STARt. Children (Basel) 2021 Jan 21;8(2). doi: 10.3390/children8020069. PubMed PMID: 33494347.
  9. Ling S, Brown K, Miksza JK, Howells LM, Morrison A, Issa E, Yates T, Khunti K, Davies MJ, Zaccardi F. Risk of cancer incidence and mortality associated with diabetes: A systematic review with trend analysis of 203 cohorts. Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):14-22. doi: 10.1016/j.numecd.2020.09.023. Epub 2020 Sep 25. PubMed PMID: 33223399.
  10. Marx N, Davies MJ, Grant PJ, Mathieu C, Petrie JR, Cosentino F, Buse JB. Guideline recommendations and the positioning of newer drugs in type 2 diabetes care. Lancet Diabetes Endocrinol 2021 Jan;9(1):46-52. doi: 10.1016/S2213-8587(20)30343-0. Epub 2020 Nov 4. Review. PubMed PMID: 33159841.
  11. Rowlands AV, Kloecker DE, Chudasama Y, Davies MJ, Dawkins NP, Edwardson CL, Gillies C, Khunti K, Razieh C, Islam N, Zaccardi F, Yates T. Association of Timing and Balance of Physical Activity and Rest/Sleep With Risk of COVID-19: A UK Biobank Study. Mayo Clin Proc 2021 Jan;96(1):156-164. doi: 10.1016/j.mayocp.2020.10.032. Epub 2020 Oct 31. PubMed PMID: 33413813; PubMed Central PMCID: PMC7604071.
  12. Dawkins NP, Yates T, Edwardson CL, Maylor B, Davies MJ, Dunstan D, Highton PJ, Herring LY, Khunti K, Rowlands AV. Comparing 24 h physical activity profiles: Office workers, women with a history of gestational diabetes and people with chronic disease condition(s). J Sports Sci 2021 Jan;39(2):219-226. doi: 10.1080/02640414.2020.1812202. Epub 2020 Aug 25. PubMed PMID: 33459582.
  13. Coles B, Zaccardi F, Hvid C, Davies MJ, Khunti K. Cardiovascular events and mortality in people with type 2 diabetes and multimorbidity: A real-world study of patients followed for up to 19 years. Diabetes Obes Metab 2021 Jan;23(1):218-227. doi: 10.1111/dom.14218. Epub 2020 Oct 22. PubMed PMID: 33026165.
  14. Dibato JE, Montvida O, Zaccardi F, Sargeant JA, Davies MJ, Khunti K, Paul SK. Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S. Diabetes Care 2021 Jan;44(1):231-239. doi: 10.2337/dc20-2045. Epub 2020 Nov 11. PubMed PMID: 33177170.
  15. Sargeant JA, Jelleyman C, Coull NA, Edwardson CL, Henson J, King JA, Khunti K, McCarthy M, Rowlands AV, Stensel DJ, Waller HL, Webb DR, Davies MJ, Yates T. Improvements in Glycemic Control After Acute Moderate-Intensity Continuous or High-Intensity Interval Exercise Are Greater in South Asians Than White Europeans With Nondiabetic Hyperglycemia: A Randomized Crossover Study. Diabetes Care 2021 Jan;44(1):201-209. doi: 10.2337/dc20-1393. Epub 2020 Nov 6. PubMed PMID: 33158948.


2020 Publications

2019 Publications

2018  Publications

2017  Publications

2016  Publications

2015 Publications

2014 Publications

2013 Publications

2012 Publications

2011 Publications

2010 Publications

2009 Publications

2008 Publications

2007 Publications

2006 Publications

2000 - 2005 Publications

1990 - 1999 Publications


  • Diabetes
  • Obesity
  • Cardiovascular disease
  • Sedentary behaviour
  • Physical activity


Current PhD students

  • Sue Craddock January 2010 –
    University of Leicester, jointly with Professor M Davies and R Baker, Department of Health Sciences
    A Study of Quality Development Processes of a structured self-management education programme within the UK (DESMOND Newly Diagnoses programme.)
  • Nitin Gholap September 2012 –
    University of Leicester, jointly with Professor M Davies and Professor K Khunti, Department of Health Sciences
    Prevalence and prognostic implications of chronic hyperglycaemia in South Asian and White European individuals following an acute myocardial infarction
  • Zin Zin Htike January 2014 –
    University of Leicester jointly with Professor M Davies and Professor K Khunti, Department of Health Sciences
    Impact of Liraglutide on cardiac function and structure in young adults with type 2 diabetes
  • Kishan Bakrania May 2014 –
    Department of Health Sciences, Professor M Davies and Professor K Khunti
    Analysing accelerometer data via novel approaches
  • Michelle Hadjiconstantinou September 2014 –
    Department of Health Sciences, Professor M Davies
    We based intervention to promote psychological wellbeing and self-management in type 2 diabetes
  • Shaun Barber October 2012 –
    Department of Health Sciences
    Screening tools for individuals at high risk of glucose disorders and cardiovascular disease from multi ethnic and minority populations
  • Sarah Bunnewell October 2015 –
    Department of Health Sciences, Professor M Davies, Professor K Khunti, Professor T Yates
    Hypoglycaemia Risk in South Asian Patients with Type 2 Diabetes
  • Francesco Zaccardi January 2015 –
    Department of Health Sciences, Professor M Davies and Professor K Khunti
    Relationship between hypoglycaemia, physical activity, inflammation and other markers of cardiovascular risk in type 2 diabetes mellitus.

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