Dr David Webb MBChB, FRCS, PhD, BSc, PG (cert)

Senior Lecturer in Diabetes Medicine

Consultant Physician in Diabetes, Endocrinology and General Internal Medicine

Contact details

Diabetes Research Centre
University of Leicester
Leicester General Hospital
Gwendolen Road, Leicester, LE5 4PW

Telephone: + 00 44 116 258 8554

Email: drw17@le.ac.uk

Personal details

  • MBChB
  • PhD
  • BSc
  • FRCP
  • FHEA

Professional activities

  • DRC Postgraduate tutor
  • Trust clinical lead for complex type 2 and specialist obesity management
  • Director: University of Leicester Diabetes masters programme

Current Projects

  • Leicester Biomedical Research Centre: Lifestyle theme and training lead
  • ADDITION - Europe Collaborative (Screening studies for Type 2 Diabetes)
  • STRIVE Study - PI Leicester site

Research Interests

  • Novel Therapeutics in Type 2 Diabetes and Obesity
  • Vascular responses to endothelial dysfunction in chronic disease
  • Lifestyle based interventions in the management and prevention of metabolic conditions

Teaching

  • Fellow of the Higher Education Academy
  • Director of Diabetes Masters programme by distance learning
  • External Examiner: Brighton and Sussex Medical School Postgraduate certificate in Primary Care Diabetes

Publications

2018

Zaccardi F, Dhalwani NN, Webb DR, Davies MJ, Khunti K. Global burden of hypoglycaemia-related mortality in 109 countries, from 2000 to 2014: an analysis of death certificates. Diabetologia. 2018 Jul;61(7):1592-1602. doi: 10.1007/s00125-018-4626-y. Epub 2018 May 1. PMID: 29717336

Osman MW, Nath M, Breslin E, Khalil A, Webb DR, Robinson TG, Mousa HA. Association between arterial stiffness and wave reflection with subsequent development of placental-mediated diseases during pregnancy: findings of a systematic review and meta-analysis. J Hypertens. 2018 May;36(5):1005-1014. doi: 10.1097/HJH.0000000000001664. PMID: 29334489

Gulsin GS, Swarbrick DJ, Hunt WH, Levelt E, Graham-Brown MPM, Parke KS, Wormleighton JV, Lai FY, Yates T, Wilmot EG, Webb DR, Davies MJ, McCann GP. Relation of Aortic Stiffness to Left Ventricular Remodeling in Younger Adults With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1395-1400. doi: 10.2337/db18-0112. Epub 2018 Apr 16. PMID: 29661781

Osman MW, Nath M, Khalil A, Webb DR, Robinson TG, Mousa HA. The effects of metformin on maternal haemodynamics in gestational diabetes mellitus: A pilot study. Diabetes Res Clin Pract. 2018 May;139:170-178. doi: 10.1016/j.diabres.2018.03.003. Epub 2018 Mar 7. PMID: 29524482

Zaccardi F, Dhalwani NN, Dales J, Mani H, Khunti K, Davies MJ, Webb DR. Comparison of glucose-lowering agents after dual therapy failure in type 2 diabetes: A systematic review and network meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2018 Apr;20(4):985-997. doi: 10.1111/dom.13185. Epub 2018 Jan 8. PMID: 29205774

2017

Sargeant JA, Aithal GP, Takamura T, Misu H, Takayama H, Douglas JA, Turner MC, Stensel DJ, Nimmo MA, Webb DR, Yates T, King JA. The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men. Appl Physiol Nutr Metab. 2018 May;43(5):482-490. doi: 10.1139/apnm-2017-0639. Epub 2017 Dec 8. PMID: 29220580

Osman MW, Leone F, Nath M, Khalil A, Webb DR, Robinson TG, Mousa HA. Diurnal variation and repeatability of arterial stiffness and cardiac output measurements in the third trimester of uncomplicated pregnancy. J Hypertens. 2017 Dec;35(12):2436-2442. doi: 10.1097/HJH.0000000000001482. PMID: 28719470

Webb M, Davies MJ, Ashra N, Bodicoat DH, Brady EM, Webb DR, Moulton C, Ismail K, Khunti K. The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women. PLoS One. 2017 Nov 30;12(11):e0187448. doi: 10.1371/journal.pone.0187448. eCollection 2017. PMID: 29190710

Osman MW, Nath M, Khalil A, Webb DR, Robinson TG, Mousa HA. Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women. Pregnancy Hypertens. 2017 Oct;10:256-261. doi: 10.1016/j.preghy.2017.10.007. Epub 2017 Oct 16. PMID: 29089251

Zaccardi F, Webb DR, Davies MJ, Dhalwani NN, Housley G, Shaw D, Hatton JW, Khunti K. Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England. Diabetes Obes Metab. 2017 Oct;19(10):1371-1378. doi: 10.1111/dom.12941. Epub 2017 Apr 21. PMID: 28295974

O'Donovan G, Chudasama Y, Grocock S, Leigh R, Dalton AM, Gray LJ, Yates T, Edwardson CL, Hill S, Henson J, Webb DR, Khunti K, Davies MJ, Jones AP, Bodicoat DH, Wells A. The association between air pollution and type 2 diabetes in a large cross-sectional study in Leicester: The CHAMPIONS Study. Environ Int. 2017 Jul;104:41-47. doi: 10.1016/j.envint.2017.03.027. Epub 2017 Apr 13. PMID: 28411585

Zaccardi F, Webb DR, Davies MJ, Dhalwani NN, Gray LJ, Chatterjee S, Housley G, Shaw D, Hatton JW, Khunti K. Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation. Diabetologia. 2017 Jun;60(6):1007-1015. doi: 10.1007/s00125-017-4235-1. Epub 2017 Mar 17. PMID: 28314943

Webb DR, Zaccardi F, Davies MJ, Griffin SJ, Wareham NJ, Simmons RK, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Khunti K. Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes. Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2877. Epub 2017 Mar 2. PMID: 28029211

Htike ZZ, Zaccardi F, Papamargaritis D, Webb DR, Khunti K, Davies MJ. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab. 2017 Apr;19(4):524-536. doi: 10.1111/dom.12849. Epub 2017 Feb 17. PMID: 27981757

2016

Zaccardi F, Dhalwani NN, Papamargaritis D, Webb DR, Murphy GJ, Davies MJ, Khunti K. Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies. Diabetologia. 2017 Feb;60(2):240-248. doi: 10.1007/s00125-016-4162-6. Epub 2016 Nov 25. PMID: 27888288

Kar D, Gillies C, Zaccardi F, Webb DR, Seidu S, Tesfaye S, Davies MJ, Khunti K. Relationship of cardiometabolic parameters in non-smokers, current smokers, and quitters in diabetes: a systematic review and meta-analysis. Cardiovasc Diabetol. 2016 Nov 24;15(1):158. doi: 10.1186/s12933-016-0475-5 PMID: 27881170

Htike ZZ, Yates T, Brady EM, Webb DR, Gray LJ, Swarbrick D, McCann GP, Khunti K, Davies MJ. Rationale and design of the randomised controlled trial to assess the impact of liraglutide on cardiac function and structure in young adults with type 2 diabetes (the LYDIA study). Cardiovasc Diabetol. 2016 Jul 21;15(1):102. doi: 10.1186/s12933-016-0421-6. PMID: 27440110

Osman MW, Sambhwani S, Khalil A, Webb DR, Robinson T, Mousa H. Pilot study: To determine whether there is a diurnal variation in arterial stiffness and non-invasive cardiac output measurements in the third trimester of pregnancy among low risk pregnant women. British Journal of Obstetrics and Gynaecology. 2016 June 21; 123:246. doi:10.1111/1471-0528.14115

Zaccardi F, Davies MJ, Dhalwani NN, Webb DR, Housley G, Shaw D, Hatton JW, Khunti K. Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study. Lancet Diabetes Endocrinol. 2016 Aug;4(8):677-85. doi: 10.1016/S2213-8587(16)30091-2. Epub 2016 Jun 9. PMID: 27293218

Zaccardi F, Webb DR, Htike ZZ, Youssef D, Khunti K, Davies MJ. Efficacy and safety of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes mellitus: systematic review and network meta-analysis. Diabetes Obes Metab. 2016 Aug;18(8):783-94. doi: 10.1111/dom.12670. Epub 2016 May 13. PMID: 27059700

Bodicoat DH, Khunti K, Srinivasan BT, Mostafa S, Gray LJ, Davies MJ, Webb DR. Incident Type 2 diabetes and the effect of early regression to normoglycaemia in a population with impaired glucose regulation. Diabet Med. 2017 Mar;34(3):396-404. doi: 10.1111/dme.13091. Epub 2016 Mar 3. PMID: 26871995

2015

Zaccardi F, Htike ZZ, Webb DR, Khunti K, Davies MJ. Benefits and Harms of Once-Weekly Glucagon-like Peptide-1 Receptor Agonist Treatments: A Systematic Review and Network Meta-analysis. Ann Intern Med. 2016 Jan 19;164(2):102-13. doi: 10.7326/M15-1432. Epub 2015 Dec 8. PMID: 26642233

Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 2016 Feb;92(1084):63-9. doi: 10.1136/postgradmedj-2015-133281. Epub 2015 Nov 30. PMID: 26621825

Arjunan SP, Deighton K, Bishop NC, King J, Reischak-Oliveira A, Rogan A, Sedgwick M, Thackray AE, Webb DR, Stensel DJ. The effect of prior walking on coronary heart disease risk markers in South Asian and European men. Eur J Appl Physiol. 2015 Dec;115(12):2641-51. doi: 10.1007/s00421-015-3269-7. Epub 2015 Oct 5. PMID: 26438068

Zaccardi F, Webb DR, Khunti K, Davies MJ. Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. (Diabetes 2015;64:673-686). Diabetes. 2015 Oct;64(10):e35-6. doi: 10.2337/db15-0649.PMID: 26405278

Zaccardi F, O'Donovan G, Webb DR, Yates T, Kurl S, Khunti K, Davies MJ, Laukkanen JA. Cardiorespiratory fitness and risk of type 2 diabetes mellitus: A 23-year cohort study and a meta-analysis of prospective studies. Atherosclerosis. 2015 Nov;243(1):131-7. doi: 10.1016/j.atherosclerosis.2015.09.016. Epub 2015 Sep 11. PMID: 26386209

Zaccardi F, Webb DR, Kurl S, Khunti K, Davies MJ, Laukkanen JA. Inverse association between fasting plasma glucose and risk of ventricular arrhythmias. Diabetologia. 2015 Aug;58(8):1797-802. doi: 10.1007/s00125-015-3646-0. Epub 2015 Jun 3. PMID: 26032023

Carter P, Bodicoat DH, Quinn LM, Zaccardi F, Webb DR, Khunti K, Davies MJ. Serum potassium and glucose regulation in the ADDITION-Leicester screening study. J Diabetes Res. 2015;2015:923749. doi: 10.1155/2015/923749. Epub 2015 Mar 25. PMID: 25883988

Zaccardi F, Webb DR, Carter P, Pitocco D, Khunti K, Davies MJ, Kurl S, Laukkanen JA. Association between direct measurement of active serum calcium and risk of type 2 diabetes mellitus: A prospective study. Nutr Metab Cardiovasc Dis. 2015 Jun;25(6):562-8. doi: 10.1016/j.numecd.2015.02.013. Epub 2015 Mar 4. PMID: 25933474

Prior to 2015

Bodicoat DH, O'Donovan G, Dalton AM, Gray LJ, Yates T, Edwardson CL, Hill S, Webb DR, Khunti K, Davies MJ, Jones AP (2014). The association between neighbourhood greenspace and type 2 diabetes in a large cross-sectional study. BMJ Open. 2014 Dec 23;4(12):e006076. doi: 10.1136/bmjopen-2014-006076. PMID: 25537783

Major RW, Davies MJ, Crasto W, Gray LJ, Webb DR, Khunti K (2014). Association between undiagnosed hypertension and microalbuminuria in South Asians without known diabetes. J Hum Hypertens. 2015 Mar;29(3):185-9. doi: 10.1038/jhh.2014.62. Epub 2014 Aug 14. PMID: 25119886

Webb DR, Herbert K, Davies MJ, Khunti K, Sattar N, Stehouwer CD (2013). Biomarker research in glucose disorders: current concepts and clinical applications. J Diabetes Res. 2013;2013:290671. doi: 10.1155/2013/290671. Epub 2013 Jun 17. PMID: 23844372

Webb DR, Khunti K, Chatterjee S, Jarvis J, Davies MJ (2013). Adipocytokine associations with insulin resistance in British South Asians. J Diabetes Res. 2013;2013:561016. doi: 10.1155/2013/561016. Epub 2013 Feb 25. PMID: 23671875

Khunti K, Morris DH, Weston CL, Gray LJ, Webb DR, Davies MJ (2013). Joint prevalence of diabetes, impaired glucose regulation, cardiovascular disease risk and chronic kidney disease in South Asians and White Europeans. PLoS One. 2013;8(1):e55580. doi: 10.1371/journal.pone.0055580. Epub 2013 Jan 30. PMID: 23383233

Brady EM, Webb DR, Morris DH, Khunti K, Talbot DS, Sattar N, Davies MJ (2012). Investigating endothelial activation and oxidative stress in relation to glycaemic control in a multiethnic population. Exp Diabetes Res. 2012;2012:386041. doi: 10.1155/2012/386041. Epub 2012 Dec 6. PMID: 23304116

Webb DR, Khunti K, Lacy P, Gray LJ, Mostafa S, Talbot D, Williams B, Davies MJ (2012). Conduit vessel stiffness in British south Asians of Indian descent relates to 25-hydroxyvitamin D status. J Hypertens. 2012 Aug;30(8):1588-96. doi: 10.1097/HJH.0b013e328354f385. PMID: 22688263

Mostafa SA, Davies MJ, Webb DR, Srinivasan BT, Gray LJ, Khunti K (2012). Independent effect of ethnicity on glycemia in South Asians and white Europeans. Diabetes Care. 2012 Aug;35(8):1746-8. doi: 10.2337/dc11-2079. Epub 2012 Jun 14. PMID: 22699291

Webb DR, Khunti K, Gray LJ, Srinivasan BT, Farooqi A, Wareham N, Griffin SC, Davies MJ; ADDITION-Leicester study group (2012). Intensive multifactorial intervention improves modelled coronary heart disease risk in screen-detected Type 2 diabetes mellitus: a cluster randomized controlled trial. Diabet Med. 2012 Apr;29(4):531-40. doi: 10.1111/j.1464-5491.2011.03441.x. PMID: 21913966

Gray LJ, Davies MJ, Hiles S, Taub NA, Webb DR, Srinivasan BT, Khunti K (2012). Detection of impaired glucose regulation and/or type 2 diabetes mellitus, using primary care electronic data, in a multiethnic UK community setting. Diabetologia. 2012 Apr;55(4):959-66. doi: 10.1007/s00125-011-2432-x. Epub 2012 Jan 10. PMID: 22231125

Gray LJ, Yates T, Davies MJ, Brady E, Webb DR, Sattar N, Khunti K (2011). Defining obesity cut-off points for migrant South Asians. PLoS One. 2011;6(10):e26464. doi: 10.1371/journal.pone.0026464. Epub 2011 Oct 19. PMID: 22039493

Burton JO, Gray LJ, Webb DR, Davies MJ, Khunti K, Crasto W, Carr SJ, Brunskill NJ (2011). Association of anthropometric obesity measures with chronic kidney disease risk in a non-diabetic patient population. Nephrol Dial Transplant. 2012 May;27(5):1860-6. doi: 10.1093/ndt/gfr574. Epub 2011 Sep 29. PMID: 21965589

Aujla N, Davies MJ, Skinner TC, Gray LJ, Webb DR, Srinivasan B, Khunti K (2011). The association between anxiety and measures of glycaemia in a population-based diabetes screening programme. Diabet Med. 2011 Jul;28(7):785-8. doi: 10.1111/j.1464-5491.2011.03245.x. PMID: 21672003

Webb DR, Gray LJ, Khunti K, Srinivasan B, Taub N, Campbell S, Barnett J, Farooqi A, Echouffo-Tcheugui JB, Griffin SJ, Wareham NJ, Davies MJ (2011). Screening for diabetes using an oral glucose tolerance test within a western multi-ethnic population identifies modifiable cardiovascular risk: the ADDITION-Leicester study. Diabetologia. 2011 Sep;54(9):2237-46. doi: 10.1007/s00125-011-2189-2. Epub 2011 Jun 3. PMID: 21638133

Webb DR, Gray LJ, Khunti K, Campbell S, Dallosso H, Davies MJ (2010). Contrasting cardiovascular risk profiles and prescribed cardio-protective therapies in newly-diagnosed type 2 diabetes identified through screening and standard practice. Diabetes Res Clin Pract. 2011 Mar;91(3):280-5. doi: 10.1016/j.diabres.2010.11.021. Epub 2010 Dec 30. PMID: 21194777

Gray LJ, Tringham JR, Davies MJ, Webb DR, Jarvis J, Skinner TC, Farooqi AM, Khunti K (2010). Screening for type 2 diabetes in a multiethnic setting using known risk factors to identify those at high risk: a cross-sectional study. Vasc Health Risk Manag. 2010 Oct 5;6:837-42. doi: 10.2147/VHRM.S12504. PMID: 20957129

Gray LJ, Taub NA, Khunti K, Gardiner E, Hiles S, Webb DR, Srinivasan BT, Davies MJ (2010). The Leicester Risk Assessment score for detecting undiagnosed Type 2 diabetes and impaired glucose regulation for use in a multiethnic UK setting. Diabet Med. 2010 Aug;27(8):887-95. doi: 10.1111/j.1464-5491.2010.03037.x. PMID: 20653746

Webb DR, Khunti K, Silverman R, Gray LJ, Srinivasan B, Lacy PS, Williams B, Davies MJ (2010). Impact of metabolic indices on central artery stiffness: independent association of insulin resistance and glucose with aortic pulse wave velocity. Diabetologia. 2010 Jun;53(6):1190-8. doi: 10.1007/s00125-010-1689-9. Epub 2010 Mar 6. PMID: 20213236

Webb DR, Khunti K, Srinivasan B, Gray LJ, Taub N, Campbell S, Barnett J, Henson J, Hiles S, Farooqi A, Griffin SJ, Wareham NJ, Davies MJ (2010). Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening. Trials. 2010 Feb 19;11:16. doi: 10.1186/1745-6215-11-16. PMID: 20170482

Webb DR, Davies MJ, Gray LJ, Abrams KR, Srinivasan B, Das S, Taub N, Lawrence I, Sutton S, Khunti K (2009). Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones. Diabetes Obes Metab. 2010 Feb;12(2):124-32. doi: 10.1111/j.1463-1326.2009.01122.x. Epub 2009 Nov 17. PMID: 19922476

Supervision

  • Dr Dimitris Papamargaritis. Feburary 2018 – April 2021. Educational / Academic supervisor with Professor M. Davies. NIHR IAT programme: Academic Clinical Lectureship in diabetes, obesity and metabolism.
  • Dr Francesco Zaccardi April 2015 – May 2018. PhD University of Leicester, joint supervisor with Professor M. Davies.
  • Dr Zin Htike Jan 2016 – July 2018. PhD University of Leicester, joint supervisor with Professor M. Davies.
  • Dr Waseem Osman Jan 2016 – March 2018. MD University of Leicester, joint supervisor with Professor T. Robinson (Department of Cardiovascular Sciences) and Dr T. Mousa (Department of Health Sciences).
  • Mr Soteris Xenophontos Jan 2016 – March 2019. PhD University of Leicester, joint supervisor with Professor A Smith (Department of Infection, Inflammation and Immunity)
  • Mr Mathew Roberts Jan 2017 – Dec 2019. PhD University of Loughborough, joint supervisor with Professor D Stensel (National Centre Sports and Exercise Medicine)
  • Dr Mukhtar Uquaili  March 2018 – Feb 2019. MSc dissertation supervisor University of Leicester
  • Miss Michela Dario March 2018 – August 2018. ERASMUS Programme supervisor.

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