Dr Francesco Zaccardi, Phd, MD

Contact details

Diabetes Research Centre
University of Leicester
Leicester General Hospital
Gwendolen Road, Leicester, LE5 4PW

Phone  no : 0116 2584974

Email: fz43@leicester.ac.uk

Role

Dr Francesco Zaccardi is a Clinical Epidemiologist and the Deputy Director at the Leicester Real-World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK. He is also a Senior Clinical Lecturer for General (Internal) Medicine at the University Hospitals of Leicester, Leicester, UK

General Research Interests:

In the last five years, he has focused his interests on medical statistics and clinical epidemiology of chronic diseases. He is primarily interested in:

1. The epidemiological transition in the causes of death in developed countries;
2. The comparative relevance of socio-economic and lifestyle factors vs classical cardiometabolic traits as determinants of chronic diseases and death
3. Analysing cohort studies from a demographic perspective
4. Novel and more intuitive measures of risk

Publications

2020

84. Chudasama YV, Khunti K, Gillies CL, Dhalwani NN, Davies MJ, Yates T, Zaccardi F. Healthy lifestyle and life expectancy in people with multimorbidity in the UK Biobank: A longitudinal cohort study. PLoS Medicine 2020 Sep 22; 17(9):e1003332. Doi: 10.1371/journal.pmed.1003332. ECollection 2020 Sep.PMID: 32960883

83. Ling S, Brown K, Miksza JK, Howells L, Morrison A, Issa E, Yates T, Khunti K. Davies MJ, Zaccardi F. Association of Type 2 Diabetes with Cancer: A Meta-analysis With Bias Analysis for Unmeasured Confounding in 151 Cohorts Comprising 32 Million people. Diabetes Care 2020 Sep. 43(9): 2313-2322. DOI: 10.2337/dc20-0204.PMID : 32910779

82. Seidu S, Gillies C, Zaccardi F, Kunutsor SK, Hartmann-Boyce J, Yates T, Singh AK, Davies MJ,Khunti K . The impact of obesity on severe disease and mortality in people with SARS-CoV-2: A systematic review and meta-analysis. Endocrinology, Diabetes and metabolism 2020 Aug. DOI: 10.1002/edm2.176

83. Zaccardi F, Jacquot E, Cortese V, Tyrer F, Seidu S, Davies MJ, Khunti K. Comparative  effectiveness of gliclazide modified release vs sitagliptin as second-line treatment after metformin in monotherapy in patients with uncontrolled type 2 diabetes. Diabetes, Obesity and Metabolism 2020 Aug. DOI: 10.1111/dom.14169. PMID: 32761768

82. Zaccardi F, Ling S, Lawson C, Davies MJ, Khunti K. Severe hypoglycaemia and absolute risk of cause-specific mortality in individuals with type 2 diabetes: a UK primary care observational study. Diabetologia 2020 Jul 30. DOI: 10.1007/s00125-020-05223-3. [Online ahead of print]. PMID: 32728893

81Lee E, Willeit P, Laukkanen T, Kunutsor SK, Zaccardi F, Khan H, Laukkanen JA. Acute effects of exercise and sauna as a single intervention on arterial compliance. European Journal of Prev Cardio. 2020 July 27(10):1104-1107.Doi: 10.1177/2047487319855454. [Epub 2019 Jun 8].PMID: 31177835

80. Nickinson ATO, Coles B, Zaccardi F, Gray LJ, Payne T, Bown MJ, Davies RSM, Khunti K, Sayers RD. Missed Opportunities for Timely Recognition of Chronic Limb-Threatening Ischaemia in Patients Undergoing a Major Amputation: A Population Based Cohort Study Using the UK's Clinical Practice Research Datalink. Eur J Vasc Endovasc Surg 2020 Jul .24:S1078-5884(20)30427-5. DOI: 10.1016/j.ejvs.2020.05.010. [Online ahead of print]. PMID: 32718828

79. Razieh C, Zaccardi F, Davies MJ, Khunti K, Yates T. Body mass index and risk of COVID-19 across ethnic groups: analysis of UK Biobank study. Diabetes, Obesity and Metabolism 2020 Jun 29. DOI: 10.1111/dom.14125. [Epub ahead of print]. PMID: 32602268

78. Chudasama YV, Gillies CL, Zaccardi F, Coles B, Davies MJ, Seidu S, Khunti K. Impact of COVID-19 on routine care for chronic diseases : A global survey of views from healthcare professionals. Diabetes and Metabolic Syndrome 2020 Jun.14 (5): 965-967. DOI: 10.1016/j.dsx.2020.06.042.[Epub ahead of print]. PMID: 32604016

77. Levene LS, Coles B, Davies MJ, Hanif W, Zaccardi F, Khunti K. COVID-19 cumulative mortality rates for frontline healthcare staff in England. British Journal of General Practice 2020 Jun.70 (696): 327-328. DOI: 10.3399/bjgp20X710837. PMID: 32586803

76. Singh AK, Gillies CL, Singh R, Singh A, Chudasama Y, Coles B, Seidu S, Zaccardi F, Davies MJ, Khunti K. Prevalence of comorbidities, and their association with mortality in patients with COVID-19: A Systematic Review and Meta-analysis. Diabetes Obesity & Metabolism 2020 Jun 23. DOI: 10.1111/dom.14124. [Online ahead of print]. PMID: 32573903

75. Chudasama YV, Gillies CL, Appiah K, Zaccardi F, Razieh C, Davies MJ, Yates T, Khunti K. Multimorbidity and SARS-CoV-2 infection in UK Biobank. Diabetes & Metabolic Syndrome 2020 Jun.14 (5):775-776. DOI: 10.1016/j.dsx.2020.06.003.[Epub ahead of print]. PMID: 32526265

74. Sargeant JA, Brady EM, Zaccardi F, Tippins F, Webb DR, Aroda VR, Gregg EW, Khunti K, Davies MJ. Adults with early-onset type 2 diabetes (aged 18-39 years) are severely underrepresented in diabetes clinical research trials. Diabetologia 2020 Jun. DOI: 10.1007/s00125-020-05174-9. PMID: 32483683

73. Yates T, Razieh C, Zaccardi F, Davies MJ, Khunti K. Obesity and Risk of COVID-19:Analysis of UK Biobank. Primary care Diabetes 2020 May. 28; S1751-9918(20)30196-0.DOI: 10.1016/j.pcd.2020.05.011. [Epub ahead of print]. PMID: 32493608

72. Laukkanen JA, Kunutsor SK, Yates T, Willeit P, Kujala UM, Khan H, Zaccardi F. Prognostic Relevance of Cardiorespiratory Fitness as Assessed by Submaximal Exercise Testing for All-cause Mortality : A UK Biobank Prospective study. Mayo clinic proceedings 2020 May.95(5):867-878. DOI : 10.1016/j.mayocp.2019.12.030. PMID: 32370851

71. Henson J, Edwardson CL, Celis-Morales CA, Davies MJ, Dunstan DW, Esliger DW, Gill JMR, Kazi A, Khunti K, King J, McCarthy M, Sattar N, Stensel DJ, Velayudhan L, Zaccardi F, Yates T. Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting. Medicine and Science in Sports and Exercise 2020 Jun. 52(6):1385-1393. DOI: 10.1249/MSS.0000000000002249.PMID: 31895295

70. Davies MJ, Kloecker DE, Webb DR, Khunti K, Zaccardi F. Number needed to treat in cardiovascular outcome trials with glucagon-like peptide-1 receptor agonists: A systematic review with temporal analysis. Diabetes Obesity & Metabolism 2020 May. DOI: 10.1111/dom.14066. [Epub ahead of print]. PMID: 32372425

69. Bhake R, Russell GM, Kershaw Y, Stevens K, Zaccardi F, Warburton VEC, Linthorst ACE, Lightman SL. Continuous free Cortisol Profiles in Healthy Men.J Clin Endocrinol Metab 2020 Apr 1;105(4):dgz002. Doi: 10.1210/clinem/dgz002.PMID: 31529059

68. Tyrer F. Zaccardi F, Khunti K, Morriss R. Incidence of Depression and First-Line AntiDepressant Therapy in People with Obesity and Depression in Primary care. Obesity 2020 Apr. DOI: https://doi.org/10.1002/oby.22772.

67. Zaccardi F, Davies MJ, Khunti K. The present and future scope of real-world evidence research in diabetes: What questions can and cannot be answered and what might be possible in the future? Diabetes, Obesity and Metabolism 2020 Apr.22 Suppl 3:21-34 DOI: 10.1111/dom.13929. PMID: 32250528

66. Henson J, Edwardson CL, Davies MJ, Gill JMR, Heaney LM, Khunti K, Ng L, Sattar N, Zaccardi F, Yates T. Physical activity and lipidomics in a population at high risk of type 2 diabetes mellitus. Journal of Sports Sciences 2020. DOI: 10.1080/02640414.2020.1744836. [Epub ahead of print]. PMID: 32228122

65. Yates T, Edwardson CL, Henson J, Zaccardi F, Khunti K, Davies MJ. Prospectively Reallocating Sedentary Time: Associations with Cardiometabolic Health. Medicine and Science in Sports and Exercise 2020 Apr.52 (4):844-850. DOI:10.1249/MSS.0000000000002204. PMID: 31688653

64. Webb DR, Htike ZZ, Swarbrick DJ, Brady EM, Gray LJ, Biglands J, Gulsin GS, Henson J, Khunti K, McCann GP, Waller HL, Webb MA, Sargent J, Yates T, Zaccardi F, Davies MJ. A randomised, open label, active comparator trial assessing the effects of 26 weeks of liraglutide or sitagliptin on cardiovascular function in young obese adults with type 2 diabetes. Diabetes, Obesity and Metabolism 2020 Mar. DOI: 10.1111/dom.14023. [Epub ahead of print]. PMID: 32157772

63. Hussein H, Zaccardi F, Khunti K, Davies MJ, Patsko E, Dhalwani NN, Kloecker DE, Ioannidou E, Gray LJ. Efficacy and tolerability of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: A systematic review and network meta-analysis. Diabetes Obesity and Metabolism 2020 Feb 19. DOI: 10.1111/dom.14008. [Epub ahead of print]. PMID: 32077218

62. Lawson CA, Zaccardi F, Squire I,  Okhai H, Davies M, Huang W, Mamas M, Lam CSP, Khunti K, Kadam UT. Risk Factors for Heart Failure: 20-Year Population-Based Trends by Sex, Socioeconomic Status, and Ethnicity. Circ Heart Fail 2020 Feb. 13(2):e006472. DOI: 10.1161/CIRCHEARTFAILURE.119.006472. Epub 2020 Feb 14. PMID: 32059630

61. Yates T, Edwardson CL, Celis-Morales C, Biddle SJH, Bodicoat D, Davies MJ, Esliger D, Henson J, Kazi A, Khunti K, Sattar N, Sinclair AJ, Rowlands A, Velayudhan L, Zaccardi F, Gill JMR. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020;75(1):139-46.

60. Ling S, Sun P, Zaccardi F, Khosla S, Cooper A, Fenici P, Khunti K. Durability of glycaemic control in patients with type 2 diabetes after metformin failure: prognostic model derivation and validation using the DISCOVER study. Diabetes Obes Metab. 2020.

59. Jones P, Bibb R, Davies M, Khunti K, McCarthy M, Webb D, Zaccardi F. Prediction of Diabetic Foot Ulceration: The Value of Using Microclimate Sensor Arrays. J Diabetes Sci Technol. 2020;14(1):55-64.
58. Chudasama YV, Zaccardi F, Gillies CL, Dhalwani NN, Yates T, Rowlands AV, Davies MJ, Khunti K. Leisure-time physical activity and life expectancy in people with cardiometabolic multimorbidity and depression. J Intern Med. 2020;287(1):87-99.

2019

57. Zaccardi F, Nystrup Husemoen LL, Thorsted BL, Webb DR, Paul SK, Davies MJ, Khunti K. Selectivity of beta-blockers, cardiovascular and all-cause mortality in people with hypoglycaemia: An observational study. Nutr Metab Cardiovasc Dis. 2019;29(5):481-8.

56. Zaccardi F, Morrison AE, Khunti K, Davies MJ. Reply to Mantovani: "Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes". Liver Int. 2019;39(4):780-1.

55. Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T. Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study. Eur J Prev Cardiol. 2019:2047487319885041.

54. Zaccardi F, Davies MJ, Khunti K, Yates T. Comparative Relevance of Physical Fitness and Adiposity on Life Expectancy: A UK Biobank Observational Study. Mayo Clin Proc. 2019;94(6):985-94.

53. Yates T, Edwardson CL, Henson J, Zaccardi F, Khunti K, Davies MJ. Prospectively Reallocating Sedentary Time: Associations with Cardiometabolic Health. Med Sci Sports Exerc. 2019.

52. Webb D, Dales J, Zaccardi F, Hill S, Moore C, Farooqi A, Griffin S, Davies M, Khunti K. Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5-year and longer-term modelled outcomes of the ADDITION-Leicester study. Diabetes Metab Res Rev. 2019;35(3):e3111.

51. Vetrone LM, Zaccardi F, Webb DR, Seidu S, Gholap NN, Pitocco D, Davies MJ, Khunti K. Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis. Acta Diabetol. 2019;56(3):331-9.

50. Spanopoulos D, Okhai H, Zaccardi F, Tebboth A, Barrett B, Busse M, Webb J, Khunti K. Temporal variation of renal function in people with type 2 diabetes mellitus: A retrospective UK clinical practice research datalink cohort study. Diabetes Obes Metab. 2019;21(8):1817-23.

49. Santilli F, Zaccardi F, Liani R, Petrucci G, Simeone P, Pitocco D, Tripaldi R, Rizzi A, Formoso G, Pontecorvi A, Angelucci E, Pagliaccia F, Golato M, De Leva F, Vitacolonna E, Rocca B, Consoli A, Patrono C. In vivo thromboxane-dependent platelet activation is persistently enhanced in subjects with impaired glucose tolerance. Diabetes Metab Res Rev. 2019:e3232.

48. Salokari E, Laukkanen JA, Lehtimaki T, Kurl S, Kunutsor S, Zaccardi F, Viik J, Lehtinen R, Nikus K, Koobi T, Turjanmaa V, Kahonen M, Nieminen T. The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality. Eur J Prev Cardiol. 2019;26(2):199-207.

47. Roman M, Monaghan A, Serraino GF, Miller D, Pathak S, Lai F, Zaccardi F, Ghanchi A, Khunti K, Davies MJ, Murphy GJ. Meta-analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes. Br J Surg. 2019;106(3):181-9.

46. Rocca B, Rubboli A, Zaccardi F. Antithrombotic therapy and revascularisation strategies in people with diabetes and coronary artery disease. Eur J Prev Cardiol. 2019;26(2_suppl):92-105.

45. Pitocco D, Spanu T, Di Leo M, Vitiello R, Rizzi A, Tartaglione L, Fiori B, Caputo S, Tinelli G, Zaccardi F, Flex A, Galli M, Pontecorvi A, Sanguinetti M. Diabetic foot infections: a comprehensive overview. Eur Rev Med Pharmacol Sci. 2019;23(2 Suppl):26-37.

44. Petrucci G, Zaccardi F, Giaretta A, Cavalca V, Capristo E, Cardillo C, Pitocco D, Porro B, Schinzari F, Toffolo G, Tremoli E, Rocca B. Obesity is associated with impaired responsiveness to once-daily low-dose aspirin and in vivo platelet activation. J Thromb Haemost. 2019;17(6):885-95.

43. Morrison AE, Zaccardi F, Khunti K, Davies MJ. Causality between non-alcoholic fatty liver disease and risk of cardiovascular disease and type 2 diabetes: A meta-analysis with bias analysis. Liver Int. 2019;39(3):557-67.

42. Morrison AE, Zaccardi F, Chatterjee S, Brady E, Doherty Y, Robertson N, Hadjiconstantinou M, Daniels L, Hall A, Khunti K, Davies MJ. Self-Compassion, Metabolic Control and Health Status in Individuals with Type 2 Diabetes: A UK Observational Study. Exp Clin Endocrinol Diabetes. 2019.
Page 5 of 13

41. Miksza JK, Zaccardi F, Kunutsor SK, Seidu S, Davies MJ, Khunti K. Statins and risk of thromboembolism: A meta-regression to disentangle the efficacy-to-effectiveness gap using observational and trial evidence. Nutr Metab Cardiovasc Dis. 2019;29(10):1023-9.

40. Lee E, Willeit P, Laukkanen T, Kunutsor SK, Zaccardi F, Khan H, Laukkanen JA. Acute effects of exercise and sauna as a single intervention on arterial compliance. Eur J Prev Cardiol. 2019:2047487319855454.

39. Lawson CA, Zaccardi F, Squire I, Ling S, Davies MJ, Lam CSP, Mamas MA, Khunti K, Kadam UT. 20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study. Lancet Public Health. 2019;4(8):e406-e20.

38. Lawson CA, Zaccardi F, McCann GP, Davies MJ, Kadam UT, Khunti K. Trends in Cause-Specific Outcomes Among Individuals With Type 2 Diabetes and Heart Failure in the United Kingdom, 1998-2017. JAMA Netw Open. 2019;2(12):e1916447.

37. Laukkanen T, Lipponen J, Kunutsor SK, Zaccardi F, Araujo CGS, Makikallio TH, Khan H, Willeit P, Lee E, Poikonen S, Tarvainen M, Laukkanen JA. Recovery from sauna bathing favorably modulates cardiac autonomic nervous system. Complement Ther Med. 2019;45:190-7.

36. Kloecker DE, Zaccardi F, Baldry E, Davies MJ, Khunti K, Webb DR. Efficacy of low- and very-low-energy diets in people with type 2 diabetes mellitus: A systematic review and meta-analysis of interventional studies. Diabetes Obes Metab. 2019;21(7):1695-705.

35. Hussein H, Zaccardi F, Khunti K, Seidu S, Davies MJ, Gray LJ. Cardiovascular efficacy and safety of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: a systematic review and network meta-analysis. Diabet Med. 2019;36(4):444-52.

34. Henson J, Edwardson CL, Celis-Morales CA, Davies MJ, Dunstan DW, Esliger DW, Gill JMR, Kazi A, Khunti K, King J, McCarthy M, Sattar N, Stensel DJ, Velayudhan L, Zaccardi F, Yates T. Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting. Med Sci Sports Exerc. 2019.
33. Dhalwani NN, Zaccardi F, Waheed H, Mytton J, Papamargaritis D, Webb DR, Evison F, Lilford R, Davies MJ, Khunti K. Cardiovascular, cancer and mortality events after bariatric surgery in people with and without pre-existing diabetes: A nationwide study. J Diabetes. 2019;11(4):265-72.

32.
Clarke AL, Zaccardi F, Gould DW, Hull KL, Smith AC, Burton JO, Yates T. Association of self-reported physical function with survival in patients with chronic kidney disease. Clin Kidney J. 2019;12(1):122-8.

31. Chudasama YV, Khunti KK, Zaccardi F, Rowlands AV, Yates T, Gillies CL, Davies MJ, Dhalwani NN. Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study. BMC Med. 2019;17(1):108.

30. Bhake R, Russell GM, Kershaw Y, Stevens K, Zaccardi F, Warburton VEC, Linthorst ACE, Lightman SL. Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method. J Clin Endocrinol Metab. 2019.

29. Argyridou S, Zaccardi F, Davies MJ, Khunti K, Yates T. Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality. Nutr Metab Cardiovasc Dis. 2019;29(12):1308-15.

28. Argyridou S, Zaccardi F, Davies MJ, Khunti K, Yates T. Walking pace improves all-cause and cardiovascular mortality risk prediction: A UK Biobank prognostic study. Eur J Prev Cardiol. 2019:2047487319887281.

2018


27. Zaccardi F, Kunutsor SK, Seidu S, Davies MJ, Khunti K. Is the lower risk of venous thromboembolism with statins related to low-density-lipoprotein reduction? A network meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis. 2018;271:223-31.

26. Zaccardi F, Khunti K. Glucose dysregulation phenotypes - time to improve outcomes. Nat Rev Endocrinol. 2018;14(11):632-3.
Page 6 of 13

25. Zaccardi F, Dhalwani NN, Webb DR, Davies MJ, Khunti K. Global burden of hypoglycaemia-related mortality in 109 countries, from 2000 to 2014: an analysis of death certificates. Diabetologia. 2018;61(7):1592-602.

24. Zaccardi F, Dhalwani NN, Dales J, Mani H, Khunti K, Davies MJ, Webb DR. Comparison of glucose-lowering agents after dual therapy failure in type 2 diabetes: A systematic review and network meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2018;20(4):985-97.

23. Lee E, Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna exposure leads to improved arterial compliance: Findings from a non-randomised experimental study. Eur J Prev Cardiol. 2018;25(2):130-8.

22. Laukkanen T, Kunutsor SK, Zaccardi F, Lee E, Willeit P, Khan H, Laukkanen JA. Acute effects of sauna bathing on cardiovascular function. J Hum Hypertens. 2018;32(2):129-3

21. Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study. BMC Med. 2018;16(1):219.

20. Kunutsor SK, Khan H, Zaccardi F, Laukkanen T, Willeit P, Laukkanen JA. Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study. Neurology. 2018;90(22):e1937-e44.

19. Kunutsor SK, Hakkinen A, Zaccardi F, Laukkanen T, Lee E, Willeit P, Khan H, Laukkanen JA. Short-term effects of Finnish sauna bathing on blood-based markers of cardiovascular function in non-naive sauna users. Heart Vessels. 2018;33(12):1515-24.

18. Hussein H, Zaccardi F, Dhalwani NN, Davies MJ, Khunti K, Gray LJ. Efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis study protocol. BMJ Open. 2018;8(11):e023206.

17. Dhalwani NN, Zaccardi F, Davies MJ, Khunti K. Body mass index and mortality in people with and without diabetes: A UK Biobank study. Nutr Metab Cardiovasc Dis. 2018;28(12):1208-16.

2017


16. Zaccardi F, Webb DR, Davies MJ, Dhalwani NN, Housley G, Shaw D, Hatton JW, Khunti K. Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England. Diabetes Obes Metab. 2017;19(10):1371-8.

15. Zaccardi F, Webb DR, Davies MJ, Dhalwani NN, Gray LJ, Chatterjee S, Housley G, Shaw D, Hatton JW, Khunti K. Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation. Diabetologia. 2017;60(6):1007-15.

14. Zaccardi F, Rocca B, Rizzi A, Ciminello A, Teofili L, Ghirlanda G, De Stefano V, Pitocco D. Platelet indices and glucose control in type 1 and type 2 diabetes mellitus: A case-control study. Nutr Metab Cardiovasc Dis. 2017;27(10):902-9.

13. Zaccardi F, Laukkanen T, Willeit P, Kunutsor SK, Kauhanen J, Laukkanen JA. Sauna Bathing and Incident Hypertension: A Prospective Cohort Study. Am J Hypertens. 2017;30(11):1120-5.

12. Zaccardi F, Khunti K. Diabetes: Predicting severe hypoglycaemia - a step forward. Nat Rev Endocrinol. 2017;13(12):692-3.

11. Zaccardi F, Dhalwani NN, Papamargaritis D, Webb DR, Murphy GJ, Davies MJ, Khunti K. Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies. Diabetologia. 2017;60(2):240-8.

10. Zaccardi F, Dhalwani NN, Davies MJ, Khunti K. Comment on: "Strengths and Limitations of Healthcare Databases in the Evaluation of Hypoglycaemia". Diabetes Obes Metab. 2017;19(10):1495-6.

9. Yates T, Zaccardi F, Dhalwani NN, Davies MJ, Bakrania K, Celis-Morales CA, Gill JMR, Franks PW, Khunti K. Association of walking pace and handgrip strength with all-cause, cardiovascular, and cancer mortality: a UK Biobank observational study. Eur Heart J. 2017;38(43):3232-40.
Page 7 of 13

8. Webb DR, Zaccardi F, Davies MJ, Griffin SJ, Wareham NJ, Simmons RK, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Khunti K. Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes. Diabetes Metab Res Rev. 2017;33(4).

7. Rizzo P, Pitocco D, Zaccardi F, Di Stasio E, Strollo R, Rizzi A, Scavone G, Costantini F, Galli M, Tinelli G, Flex A, Caputo S, Pozzilli P, Landolfi R, Ghirlanda G, Nissim A. Autoantibodies to post-translationally modified type I and II collagen in Charcot neuroarthropathy in subjects with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2017;33(2).

6. Kunutsor SK, Zaccardi F, Karppi J, Kurl S, Laukkanen JA. Is High Serum LDL/HDL Cholesterol Ratio an Emerging Risk Factor for Sudden Cardiac Death? Findings from the KIHD Study. J Atheroscler Thromb. 2017;24(6):600-8.

5. Kunutsor SK, Kurl S, Khan H, Zaccardi F, Rauramaa R, Laukkanen JA. Oxygen uptake at aerobic threshold is inversely associated with fatal cardiovascular and all-cause mortality events. Ann Med. 2017;49(8):698-709.

4. Kunutsor SK, Kurl S, Khan H, Zaccardi F, Laukkanen JA. Associations of cardiovascular and all-cause mortality events with oxygen uptake at ventilatory threshold. Int J Cardiol. 2017;236:444-50.

3. Htike ZZ, Zaccardi F, Papamargaritis D, Webb DR, Khunti K, Davies MJ. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes Metab. 2017;19(4):524-36.

2. Hamer M, Yates T, Zaccardi F, Demakakos P. Reply to: "Talking about mediation in health and physical activity sciences". Atherosclerosis. 2017;264:127-8.

1. Dhalwani NN, Zaccardi F, O'Donovan G, Carter P, Hamer M, Yates T, Davies M, Khunti K. Association Between Lifestyle Factors and the Incidence of Multimorbidity in an Older English Population. J Gerontol A Biol Sci Med Sci. 2017;72(4):528-34.

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