Leicester Biomedical Informatics Network for Education, Research and Industry - BINERI

A wide range of biomedical informatics, healthcare data management, and information technology expertise operate together in Leicester under a strategic grouping called BINERI (“Biomedical Informatics Network for Education, Research and Industry”). This network works in a unified way on topics such as bioinformatics training, data science, expertise sharing, data discovery and sharing, biobanking, big data analysis, ethics, governance, patient engagement, information technology, etc.

By integrating various complementary disciplines, combining resources, sharing PhD students and staff, and applying jointly for local, national and international funding, BINERI members are propelling forward high impact informatics initiatives across its research and NHS Trust stakeholders. These stakeholders include:

BINERI is founded on the principle that data (primary data, aggregated data, metadata, and resulting knowledge) need to be used optimally – which implies aligning research and healthcare activities to ensure professional and forward-looking data capture, management, curation, security, discovery, sharing and re-use (as per GA4GH and FAIR principles). It will also be important to stress patient-centric aspects of such developments, not least human-computer interactions and patient control of 'their' data.

BINERI teams promulgate their extensive experience in the required tooling, such as concerning healthcare data warehouses (e.g., i2b2, tranSMART, LabKey), tissue tracking (e.g., OpenSpecimen), patient relationship management (e.g., CiviCRM), eCRF platforms (e.g., REDCap, OpenClinica), CDISC standards, data discovery (e.g., Cafe Variome) and sequence variant validation (e.g., VariantValidator).

Ongoing exemplar projects include:

  • Integration of primary care data from more than 100 GP surgeries in the East Midlands for the purposes of follow-up cardiovascular and diabetes research
  • Pragmatic randomised controlled trial nested within UK primary care data to evaluate the real-life effectiveness of diabetes drugs
  • Technical underpinning of an EU-wide, federated network of Alzheimer's disease patient datasets enabling discovery (without revealing data) of subjects suitable for a multi-site longitudinal readiness cohort for clinical trials
  • Management of translational clinical and research data across large-scale UK and EU consortia in the context of precision medicine (e.g., respiratory disorders, radiotherapy)
  • Development of technological platforms such as Apps for managing chronic conditions

The resulting vibrant and productive bioinformatics environment in Leicester is further strengthened by having a dedicated bioinformatics hub, launching and funding the LPMI, holding monthly workshops between data scientists, and initiating many cross-disciplinary studentships with an emphasis on bioinformatics and personalized medicine.  BINERI collaborations with teams across the UK and internationally are diverse and numerous, with the door very much open to discussing further opportunities.  Various staff from across the network take an active part in guiding BINERI development, with day-to-day coordination provided by the BINERI strategic Chair, Professor Anthony Brookes, who can be contacted with collaboration enquiries in the first instance.

Share this page:

Contact Details

College of Life Sciences
University of Leicester
Maurice Shock Building
University Road
Leicester
LE1 7RH