Selected Publications

The following publications have been done with support from Protein Expression Laboratory resulting in direct authorship of staff or acknowledgement of the work carried out.

1. Hanna Kwon, Jaswir Basran, Cecilia M Casadei, Alistair J Fielding, Tobias E Schrader,Andreas Ostermann, Juliette M Devos, Pierre Aller, Matthew P Blakeley, Peter CE Moody,Emma L. Raven.  Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme. NATURE COMMUNICATIONS, 2016, 7: 13445 | DOI: 10.1038/ncomms13445.

2. Christopher J Millard, Niranjan Varma, Almutasem Saleh, Kyle Morris, Peter J Watson, Andrew R Bottrill, Louise Fairall, Corinne J Smith, John WR Schwabe. The structure of the core NuRD repression complex provides insights into its interaction with chromatin. eLife 2016, 5:e13941. DOI: 10.7554/eLife.13941.

3. Mikael Feracci, Jaelle N Foot,Sushma N Grellscheid, Marina Danilenko, Ralf Stehle, Oksana Gonchar, Hyun-Seo Kang, Caroline Dalgliesh, N Helge Meyer, Yilei Liu, Albert Lahat, Michael Sattler, Ian C Eperon, David J Elliott, Cyril Dominguez. Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68. NATURE COMMUNICATIONS, 2016, 7:10355 | DOI: 10.1038/ncomms10355.

 4. Peter J Watson, Christopher J Millard, Andrew M. Riley, Naomi S Robertson, Lyndsey C Wright, Himali Y. Godage, Shaun M Cowley, Andrew G Jamieson, Barry VL Potter, John W. R. Schwabe. Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. NATURE COMMUNICATIONS, 2016,  7:11262 | DOI: 10.1038/ncomms11262.

5. Mark J. Burton, Sofia M. Kapetanakib, Tatyana Chernovac, Andrew G Jamiesonb, Pierre Dorletd, Jérôme Santolinid,e, Peter CE Moody, John S Mitchesona, Noel W Daviesa, Ralf Schmida, Emma L. Ravenb, Nina M Storeya. A heme-binding domain controls regulation of ATP-dependent potassium channels. PNAS, 2016, 113 (14): 3785–3790.

6. Peter D Jones, Michael A Kaiser, Maryam Ghaderi Najafabadi, David G McVey, Allan J Beveridge, Christine L Schofield, Nilesh J Samani, Tom R Webb. The Coronary Artery Disease-associated Coding Variant in Zinc Finger C3HC-type Containing 1 (ZC3HC1) Affects Cell Cycle Regulation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2016,  291(31):16318-16327.

7. Laura O’Regan, Josephina Sampson, Mark W Richards, Axel Knebe, Daniel Roth, Fiona E. Hood, Anne Straube, Stephen J Royle, Richard Bayliss, Andrew M Fry. Hsp72 Is Targeted To The Mitotic Spindle By Nek6 To Promote K-fiber Assembly And Mitotic Progression.  J. Cell Biol. 2015, DOI: 10.1083/jcb.201409151.

8. Gregg M. Hudson, Peter J. Watson, Louise Fairall, Andrew G. Jamieson, John W. R. Schwabe. Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL.2015, 290 (29):18237–18244. 

9. Fadil A. Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef, Youssif M. Ali, Edward B. Kaczmarski, Ian Feavers, Christopher D. Bayliss.  Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR. PLOS ONE, July 24, 2015, DOI:10.1371/journal.pone.0133855.

10. Sarah R. Sabir, Navdeep K. Sahota, George D. D. Jones, Andrew M. Fry. Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging  Agents. PLOS ONE, October 26, 2015, DOI:10.1371/journal.pone.0140975. 

11. Mariola Zaleska, Claudia Fogl, Ay Lin Kho, Abdessamad Ababou, Elisabeth Ehler, Mark Pfuhl. The Cardiac Stress Response Factor Ms1 Can Bind to DNA and Has a Function in the Nucleus. PLOS ONE, December 14, 2015, DOI:10.1371/journal.pone.0144614

12. Cecilia M Casadei, Andrea Gumiero, Clive L Metcalfe, Emma J Murphy, Jaswir Basran, Maria Grazia Concilio, Susana CM Teixeira, Tobias E Schrader, Alistair J Fielding, Andreas Ostermann, Matthew P Blakeley, Emma L Raven, Peter CE Moody. Neutron Cryo-crystallography Captures the Protonation State of Ferryl Heme in A Peroxidase. Science, 2014, 345 (6193): 193-197.

13 Sian E. Evans, Benjamin T. Goult, Louise Fairall, Andrew G. Jamieson, Paul Ko Ferrigno,Robert Ford, John W. R. Schwabe, Simon D. Wagner. The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain. PLoS ONE, 2014, 9(3): e90889. doi:10.1371/journal.pone.0090889.

14. Jennifer T Patel, Andrew Bottrill, Suzanna L Prosser, Sangeetha Jayaraman, Kees Straatman, Andrew M Fry & Sue Shackleton.  Mitotic phosphorylation of SUN1 loosens its connection with the nuclear lamina while the LINC complex remains intact. Nucleus, 2014, 5 (5): 462-473

15. Jaelle N Foot, Mikael Feracci, Cyril Dominguez. Screening protein – Single stranded RNA complexes by NMR spectroscopy for structure determination. Methods, 2014, 65(3): 288–301.

16. Nicola Portolano, Peter J. Watson, Louise Fairall, Christopher J. Millard, Charles P. Milano, Yun Song, Shaun M. Cowley, John W.R. Schwabe. Recombinant Protein Expression for Structural Biology in HEK 293F Suspension Cells: A Novel and Accessible Approach. Journal of Visualized Experiments, 2014, 92: e51897.

17. Stephanie J. Ellis, Emily Lostchuck, Benjamin T. Goult, Mohamed Bouaouina, Michael J. Fairchild,Pablo Lo´ pez-Ceballos, David A. Calderwood, Guy Tanentzapf. The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering. PLoS Genet. 2014, 10(11): e1004756.

18. Samrein B.M. Ahmed, Sally A. Prigent . A nuclear export signal and oxidative stress regulate ShcD subcellular localisation A potential role for ShcD in the nucleus. Cellular Signalling, 2014 26:32–40.

19. Jaelle N. Foot , Mikael Feracci, Cyril Dominguez.  Screening protein – Single stranded RNA complexes by NMR spectroscopy for structure determination. Methods, 2014, 65 (2):288-301.

20. Rachel J Watkins, Rajashree Patil1, Benjamin T Goult, Mervyn G Thomas, Irene Gottlob, Sue Shackleton. A Novel Interaction Between FRMD7 and CASK: Evidence For A Causal Role In Idiopathic Infantile Nystagmus. Human Molecular Genetics, 2013,  22(10): 2105–2118.

21. Alessio Bortoluzzi, Frederick W. Muskett , Rieck, Thomas Munder, Susanne Schleier, Lorna C. Waters, Philip W. Addis, Barbara, Francesca Forti, Daniela Ghisotti, Mark D. Carr and Helen M. O'Hare.  Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors. J. Biol. Chem. 2013, 288:14438-14450.

22. Alexandre R. Gingras, Wilma Puzon-McLaughlin and Mark H. Ginsberg. The Structure of the Ternary Complex of Krev Interaction Trapped 1 (KRIT1) Bound to Both the Rap1 GTPase and theHeart of Glass (HEG1) Cytoplasmic Tail. THE J. BIO. CHEM. 2013, 288 (33): 23639–23649.

23. Rachel J. Watkins, Rajashree Patil, Benjamin T. Goult, Mervyn G. Thomas, Irene Gottlob and Sue Shackleton. A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile Nystagmus. Human Molecular Genetics, 2013 1–14.

24. Sven Starke1, Peter Meinke, Daria Camozzi, Elisabetta Mattioli, Roland Pfaeffle, Manuela Siekmeyer, Wolfgang Hirsch, Lars Christian Horn, Uwe Paasch, Diana Mitter, Giovanna Lattanzi, Manfred Wehnert, and Wieland Kiess. Progeroid laminopathy with restrictive dermopathy‐like features caused by an isodisomic LMNA mutation p.R435C. AGING, 2013 5:445-459.

25. Deepsharan K. Dhani, Benjamin T. Goult, Gifty M. George, Daniel T. Rogerson, Danny A. Bitton, Crispin J. Miller, John W. R. Schwabe, and Kayoko Tanaka.Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3Alp6. Molecular Biology of the Cell, 2013, 24(1):3337-3349.

26. Christopher J. Millard, Peter J. Watson, Ivana Celardo, Yuliya Gordiyenko, Shaun M. Cowley, Carol V. Robinson, Louise Fairall, John W.R. Schwabe. Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates. Molecular Cell, 2013, 51:57–67. 

27. Watson, P.J., L. Fairall, G.M. Santos and J.W.R. SchwabeStructure of HDAC3 bound to corepressor and inositol tetraphosphate. Nature, 2012, 481:335-340.

28. Alexandre R. Gingras, Jian J. Liu, and Mark H. Ginsberg. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J. Cell Biol. 2012, 199 (1):39–48.


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