19 June 2018: Professor Bibek Gooptu: Molecular Mischief: Studying the choreography of proteins to treat disease

Posted by dmrbp1 at Apr 05, 2018 10:58 AM |
Part of the Professorial Inaugural Lecture series

Professor Bibek Gooptu, of the Department of Infection, Immunity and Inflammation, will give his inaugural lecture entitled: 'Molecular Mischief: Studying the choreography of proteins to treat disease.'

This will take place at 6pm on Tuesday 19 June 2018, in the Frank and Katherine May Lecture Theatre in the Henry Wellcome Building.

Please register here



Understanding the behaviour of proteins in health - and how perturbations cause disease - provides insight into key processes supporting life at the molecular level and allows us to develop new treatment strategies. Research into a group of diseases known as the serpinopathies, that include inherited forms of emphysema, liver cirrhosis and dementia, has put these principles into practice. Whilst the serpinopathies are fascinating but rare diseases, the findings have important and wide-ranging implications.


Bibek Gooptu trained in Biomedical and Preclinical Science at the University of Manchester (1992-95). He then moved to the University of Cambridge (1995-2000) on an MB/PhD programme that integrated both advanced research and Clinical Medicine training. In his PhD he began his biochemical and structural biology research into the serpinopathies, funded by the Medical Research Council (MRC). This work won him the British Lung Foundation Young Investigator Award (1999) and the Peter Brook Prize from the University of Cambridge (2000). After completing his PhD and qualifying as a junior medical doctor he worked as a full-time clinician in hospitals in Cambridge, Nottingham, London and Essex, becoming specialised in General and Respiratory Medicine. He returned to lab research as a Wellcome Trust Clinician Scientist Fellow at Birkbeck College, London (2006-11), winning a Royal Society of Medicine Respiratory Research Prize (2012). He became a Clinical Senior Lecturer at King’s College London and a Consultant at Guy’s & St Thomas’ Hospitals in 2012. He moved to the University of Leicester in September 2016 as Professor of Respiratory Biology.

His clinical work is based at Glenfield Hospital where he works as a Consultant in Respiratory Medicine, with special interests in lung fibrosis and COPD. His research work is conducted at the NIHR Leicester Biomedical Research Centre and the Leicester Institute of Structural and Chemical Biology. The cross-disciplinary approach brings together two of Leicester’s strengths (Structural Biology and Respiratory Medicine). This allows him to combine highly detailed studies at the level of individual molecules and atoms, with studies using samples from patients, and with clinical observations. His basic-to-translational research is supported by the MRC and the Alpha-1 Foundation. He is currently the Leicester Principal Investigator for a multinational, investigator-led clinical study for the treatment of lung fibrosis associated with rheumatoid disease. He sits on the scientific advisory committee of The Alpha-1 Project, and the expert steering panel for a US National Institutes of Health research programme for the development of new drugs in 1-antitrypsin deficiency.

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