3 May 2018: Professor Frank Dudbridge

Posted by dmrbp1 at Feb 08, 2018 10:38 AM |
Part of the College of Life Sciences Inaugural Lecture series

Professor Frank Dudbridge will give his inaugural lecture on 3 May 2018, titled:

'Polygenic Epidemiology: the whole genome as a risk factor for disease.'

This lecture will take place in the Frank and Katherine May Lecture Theatre in the Henry Wellcome Building at 6pm.

Register here: https://frankdudbridge.eventbrite.co.uk

Synopsis: One hundred years since Fisher proposed a polygenic model for complex traits, genome-wide association studies have confirmed that all common diseases are influenced by thousands of genetic variants with small effects.  Current studies have discovered only a small fraction of these variants.  But by treating the whole genome as a risk factor, the polygenic basis of disease can be used in epidemiological studies without identifying all the individual risk variants.  I will review the emergence of this new field of polygenic epidemiology, discuss current applications including diagnosis, risk prediction and causal inference, and identify some challenges that lie ahead.

Biography: Frank Dudbridge obtained his BSc in Mathematics and Computing from King’s College London and his PhD from Imperial College London on the subject of fractal image compression.  After a postdoctoral fellowship at the University of California, San Diego he returned to the UK and discovered statistical genetics under John Todd at the Universities of Oxford and Cambridge.  Following an MRC training fellowship he was a senior statistician at the MRC Biostatistics Unit, then Reader and Professor of Statistical Genetics at the London School of Hygiene and Tropical Medicine before joining the University of Leicester in 2016.

His interests are in statistical methods for genetic epidemiology, in which he has made highly cited contributions to family-based association analysis, genome-wide association studies, genetic risk prediction and Mendelian randomisation. These are the fruits of collaborations with many outstanding colleagues in fields including cardiology, oncology, psychiatry and diabetes.

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College of Life Sciences
University of Leicester
Maurice Shock Building
University Road
Leicester
LE1 7RH