18 July: 'The cryoEM revolution in Structural Biology’

Posted by dmrbp1 at Jun 24, 2019 10:59 AM |
The Leicester Institute of Structural and Chemical Biology (LISCB) Flagship Lecture will be delivered by Professor Richard Henderson, Nobel Laureate, 2017 Prize for Chemistry

The seminar will take place on Thursday 18th July, 3-4pm in the Frank and Katherine May Lecture Theatre, Henry Wellcome Building.

 

The title of Professor Henderson’s talk is ‘The cryoEM revolution in Structural Biology’ and he has kindly agreed for the lecture to be opened to staff, students and general public. The seminar will be followed by a drinks reception in the Henry Wellcome Building Atrium.  For your convenience, a poster is attached.

 

Booking is essential as places are limited and can be completed by following the link here to register on Eventbrite.

 

Should you have any queries, please do not hesitate to contact the College of Life Sciences Research Support Team by email clsrso@le.ac.uk or telephoning Helen Jukes, Research Administrator on 252 2967.

 

Abstract

 

In the last few years, single particle electron cryomicroscopy (cryoEM) has experienced a quantum leap in its capability, due to improved electron microscopes, better detectors and better software, and
this is revolutionising structural biology. Using the technique invented by Jacques Dubochet and his colleagues, a thin film containing a suspension of the macromolecules of interest is plunge-frozen into
liquid ethane at liquid nitrogen temperature, creating a frozen sample in which individual images of the structures can be seen in many different orientations. Subsequent computer-based image analysis is then used to determine the three-dimensional structure, frequently at near-atomic resolution. I will discuss the trends and challenges for cryoEM in the next year or two.

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Contact Details

College of Life Sciences
University of Leicester
Maurice Shock Building
University Road
Leicester
LE1 7RH