Host-Microbial Interactions

Here at Leicester, we are interested in the complex interactions of microbial pathogens and commensals with their host. In particular, a large area under investigation is the microbial factors which facilitate adhesion to host surfaces (such as the nasopharyngeal epithelia), and those which are required for the development of disease.

This major aspect of Microbial Sciences research draws extensively on the strong relationship between basic science research based in the Departments of Genetics, Infection, Inflammation and Immunity, and Molecular and Cellular Biology, and the University Hospitals of Leicester Respiratory Medicine and Clinical Infectious Diseases, EMPATH (Nottingham Leicester Pathology service NHS).

Research interests cover a wide range of pathogens, host immunity and microbiota with projects investigating the adaptation of bacteria to the extreme environments found in the host, as well as developing methods to determine the properties of bacteria in their natural environments.

The research in this area is supported by state-of the art genetics and genomics, structural biology, models of infection, pre-clinical imaging and category 3 microbiological research (Core Biotechnology Services).

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