Bacterial Physiology and Genetics

Microbial Sciences research applies fundamental genetic mechanisms and state-of the art technologies to the study of bacterial genomes, horizontal gene transfer and the mechanisms responsible for high frequency generation of genetic variation in microbial genomes. All of which are key to the remarkable ability of bacteria to adapt to changing selective pressures (for example exposure to antibiotics and hostile immune responses).

Bacterial physiology and genetics research themes:

Phage biology in Clostridium difficile, Burkholderia, Streptococcus pneumoniae and Staphylococcus aureus
(Clokie together with Andrew, Bayliss, Galyov, Millard, Morrissey, Oggioni)

Phase variation of bacterial pathogens (including N. meningitidis, and S. pneumoniae)
(Bayliss, Oggioni)

Microbiota - their composition and role in pathology
(Ketley, Barer, Clokie )

  • Changes in the microbiome in patients suffering from antibiotic-associated Clostridium difficile mediated diarrhea
  • The effect of host responses such as inflammation and stress on the microbiome
  • The consequences on pathogen colonisation and virulence – both in man and domestic animals –on gut microbiota in chickens.
  • COPD and microbiota

 

AMR

 

Microbial physiology of Staphylococci, Streptococcus, TB, Neisseria, Campylobacter

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