Research in LCRC

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LCRC is an internationally renowned research grouping, bringing together basic and clinical scientists and having excellent links with the National Health Service. Our strategic aim is to capitalise on our strong basic scientific research programmes to expand our translational and clinical research to achieve patient benefit.

Key outcomes over the last five years have been:

  • enhanced grant funding, including two successful CR-UK Programme Grants awards;
  • renewal of our ECMC and
  • enhanced funding for mesothelioma and haematology clinical studies.

Research focuses on the following areas:


The overall aim of the Group is to develop and apply strategies for both prevention of cancer. There is an emphasis on the use of biomarkers in mechanistic studies of carcinogenesis and for monitoring the effectiveness of chemoprevention and therapy. Members of this grouping:

Professor Karen Brown
Dr Don JL Jones
Dr Alessandro Rufini
Professor Anne Thomas

Early Detection

Efforts in this area are centred on genomic profiling of circulating free DNA (cfDNA), focussing on the reliable detection of driver mutations in lung, pancreatic, colorectal and breast cancer as well as melanoma. Members of this grouping:

Dr David Guttery
Dr John Le Quesne
Dr Gerald Saldanha

Professor Jacqui Shaw

Personalised Medicine

Research on targeted therapies is primarily coupled to clinical trials of thoracic cancers and lymphoid malignancies with emphasis on overcoming drug resistance. Members of this grouping:

Professor Martin Dyer
Professor Dean Fennell
Dr David Guttery
Professor G Don Jones
Professor Bruno Morgan
Professor Catrin Pritchard
Dr John Le Quesne
Professor Jacqui Shaw
Professor Anne Thomas
Professor Simon Wagner

The conduit for translational and early phase clinical trials is our ECMC, underpinned by a dedicated Early Phase Clinical Trials Unit, funded by a partnership between the NHS Trust, the University and the locally based cancer charity Hope Against Cancer.

We also host the Ernest and Helen Scott Haematological Research Institute and are a leading centre for lung cancer and mesothelioma research.

 Our research is funded by a variety of sources including charities Cancer Research UK, Lymphoma Leukaemia Research, Hope Against Cancer as well as a number of commercial organisations.

Hope FoundationLeukemia and Lymphoma ResearchCRUK

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Well done to Rachel Norman who was awarded a travel grant whilst at the Human Proteome Organization Conference in Florida, US.


Congratulations to all of the MPTC MSc 2017-18 graduating students; in particular to Lilas Al Boushi who was awarded the Sydney King Prize as the best performing student.


The LCRC would like to say a huge “Congratulations” to Sam Khan, Bethan Rogoyski and Sarah Whelan, who scooped a plethora of awards at the 42nd Annual UKEMS Meeting held in Oxford from 2-5th September 2018.  Sam won best oral presentation for "targeting cancer stem-like cells in colorectal cancer" and Bethan and Sarah won young scientist poster awards for "From anti-helminth to anti-cancer: repurposing drugs to prevent mesothelioma" and "Harnessing the link between BRAF-mediated tumourigenesis and metabolism in colorectal cancer", respectively.  WELL DONE ALL!


In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.


All the staff and students in the LCRC extend their congratulations to Bethan Rogoyski and Sam Khan for being awarded travel bursaries from UKEMS and Health Education England respectively so they could attend the Cancer Prevention Conference in Germany.

Bethan presented her poster entitled “From Asbestos to Zinc – Can We Prevent Mesothlioma Using Repurposed Drugs?”

Sam presented her work on TBS2017-122-SK - "Targeting Nanog in colorectal tissue explant models for the evaluation of cancer prevention agents"


Congratulations from the LCRC to the following postgraduate student(s)

Saraa Barsoom on passing her viva  and being awarded her PhD on 16th August 2018


Tumour analysis following surgery could provide breakthrough in predicting how well cancer patients respond to drug treatment

Details here


New: Wellcome Trust Institutional Strategic Support Fund



Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair


Leicester Wellcome Trust Institutional Strategic Support Fund (WTISSF):  

The Leicester WTISSF aims to fund projects that cross discipline, ethnic and social boundaries to promote health. 

The latest award spans over 5 years, from 2016/17 to 2020/21. 

For more information, please click here

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170

(Please note this email address should not be used for clinical referrals or patient correspondence)

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