Professor Will Steward

Professor of Clinical OncologyPicture of Professor Will Steward

Contact Details

  • Tel: 0116 258 7597 or 0116 223 1857
  • Office: Osborne Building, Leicester Royal Infirmary, Leicester LE1 5WW

Education

  • MB, ChB (Manchester)
  • MRCP (U.K.)
  • Ph.D. (Manchester)
  • JCHMT accreditation in General (Internal) Medicine and Medical Oncology
  • FRCP (Glasgow)
  • FRCP (Canada)
  • Subspecialty accreditation in Medical Oncology (Royal College Physicians and Surgeons of Canada)
  • FRCP (London) 

Background

Will Steward’s research interests involve the clinical evaluation of novel therapies which may reduce cancer incidence or treat advanced disease.   His background was with the New Drug Development units at the Christie Hospital in Manchester, Beatson Oncology Centre in Glasgow and as Co-Director of New Drug Development at the National Cancer Institute of Canada. 

He has longstanding experience of designing and running clinical trials of new drugs in cancer with particular focus on novel agents affecting tumour biology - particularly angiogenesis inhibitors and small molecule signal transduction inhibitors.  Clinical expertise in the management of colorectal hepatobiliary, and pancreas tumours and neuroendocrine tumours.  Extensive experience with organising and running clinical trials in these diseases and currently Chair of the NCRI Colorectal Cancer Clinical Studies Group.

Research Interests

As a member of the Chemoprevention Group, this background has been utilised for planning early phase chemoprevention trials predominently involving phytochemicals derived from dietary components.  Emphasis has been on colorectal cancer prevention.  Focus to date has been examining potential role of curcumin, theaflavins, resveratrol, anthocyanins and other agents using preclinical models to indicate potential preventative efficacy, in vitro assessment of mechanisms of effect, and subsequent pilot and phase I studies in humans.  Novel strategies for choosing agents to take into trials have been developed through CRUK programme grant funding.

Work on structure/activity relationship has shown the importance of level of O-methylation of the phenol ring in determining systemic levels of polyphenolic agents and associated preventative activity. 

Current research is focussing on optimal dose and is comparing the biological effects of dietary relevant doses compared with much higher pharmacological dosing.  This will address the fundamental concern that current clinical trials in chemoprevention of agents chosen from epidemiological studies of diet then administer doses which are much higher than would be achieved from the diet.  Research also includes identification of biomarkers and predictive models of chemopreventive efficacy with the aim of allowing choice of optimal agents to take forward into clinical testing, and also being able to incorporate these into clinical trials to determine potential activity earlier than would be the case if development of cancer was the endpoint.

Publications

To view Professor Steward's publications, please use the link: PubMed Publication Listing.

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NEWS

Congratulations from the LCRC to Bethan Rogoyski and Aleksandra Bzura.

Bethan won best oral presentation at the AMS Midlands Academy of Medical Sciences Festival held on 27th March 2019 for her presentation on "Redeployment: The potential of repurposed drugs in preventing mesothelioma".

Aleks won the University PGR poster fair competition on 18th March 2019 for her poster entitled "New hope for treating mesothelioma cancer using PARP inhibitors".

Also, a huge well done to Grandezza Aburido who was in the semi-finals of the PGR poster fair.  

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Congratulations to Noura Alibrahim who passed her PhD viva recently.  Well done!

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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