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Figure 1 Exposure to DNA damaging agents from occupational, lifestyle, environmental and dietary sources

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Figure 2 Determination of B[a]PDE-N2dG adducts by LC-ESI-MS/MS SRM and 32P postlabelling in mice liver DNA at different time points following ip. dosing with A) tricaprylin, control B) 50 mg/kg B[a]P (28 days) and C) 200 mg/kg B[a]P (1 day). The internal standard (lower traces) is [15N5] B[a]PDE-N2dG.

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Figure 3 DNA adductomic maps and typical online column-switching LC-MS/MS total ion chromatograms for the analysis of deoxynucleoside adducts in a mixture consisting of a combination of calf thymus DNA modified with different PAH-dihydrodiol epoxides using (A) SRM transitions for the most abundant product ions (B) SRM transitions resulting from the neutral loss of 116 u and (C) CNL scanning for the neutral loss of 116 u.

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Figure 4 Schematic representation of the immunoslot-blot procedure used to detect malondialdehyde-deoxyguanosine (M1dG) adducts in human DNA samples.

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NEWS

Congratulations from the LCRC to Bethan Rogoyski and Aleksandra Bzura.

Bethan won best oral presentation at the AMS Midlands Academy of Medical Sciences Festival held on 27th March 2019 for her presentation on "Redeployment: The potential of repurposed drugs in preventing mesothelioma".

Aleks won the University PGR poster fair competition on 18th March 2019 for her poster entitled "New hope for treating mesothelioma cancer using PARP inhibitors".

Also, a huge well done to Grandezza Aburido who was in the semi-finals of the PGR poster fair.  

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Congratulations to Noura Alibrahim who passed her PhD viva recently.  Well done!

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

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Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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