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Figure 1 Exposure to DNA damaging agents from occupational, lifestyle, environmental and dietary sources

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Figure 2 Determination of B[a]PDE-N2dG adducts by LC-ESI-MS/MS SRM and 32P postlabelling in mice liver DNA at different time points following ip. dosing with A) tricaprylin, control B) 50 mg/kg B[a]P (28 days) and C) 200 mg/kg B[a]P (1 day). The internal standard (lower traces) is [15N5] B[a]PDE-N2dG.

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Figure 3 DNA adductomic maps and typical online column-switching LC-MS/MS total ion chromatograms for the analysis of deoxynucleoside adducts in a mixture consisting of a combination of calf thymus DNA modified with different PAH-dihydrodiol epoxides using (A) SRM transitions for the most abundant product ions (B) SRM transitions resulting from the neutral loss of 116 u and (C) CNL scanning for the neutral loss of 116 u.

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rajfig4

Figure 4 Schematic representation of the immunoslot-blot procedure used to detect malondialdehyde-deoxyguanosine (M1dG) adducts in human DNA samples.

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Powerful pre-clinical platform for anti-cancer drug and biomarker discovery

Pre-clinical models that can accurately predict outcomes in the clinic are much sort after in the field of cancer drug discovery and development.  Read about how patient derived explants offer many advantages and are the powerful model of choice. A copy of the review, published in the British Journal of Cancer, is available by clicking this link: PDE Platform

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SEND Study Success

Congratulations to Chris Avery, who with collaborating colleagues published findings of the SEND study, a multi-centre randomised trial using two different surgical protocols for mouth cancer treatment.  A nationwide first for this type of trial, using real-world data.  The paper, published in the British Journal of Cancer, is available by clicking this link: SEND Paper

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Join up for a walk on the park Friday lunchtime - details here.

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Leicester Cancer Research Centre
Robert Kilpatrick Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

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