Professor Simon Wagner

Professor and Honorary Consultant in Haemato-Oncology

Simon Wagner

Contact details

  • Tel: +44 (0)116 258 7426
  • Email: sw227@le.ac.uk
  • Office: Department of Haematology, 2nd Floor, Sandringham Building, Leicester Royal Infirmary

Personal details

Deputy Director of the Ernest and Helen Scott Haematological Research Institute

  • BSc II(i) Basic Medical Sciences with Biochemistry (London)
  • MBBS St George's Hospital Medical School (London)
  • MRCP Royal College of Physicians (UK)
  • PhD Hammersmith Hospital and Royal Postgraduate Medical School, London
  • PhD Title: Vk Gene usage in B Cell Leukaemias
  • FRCP Royal College of Physicians (UK)

Academic distinctions and national profile

  • Editor of Case Reports in Hematology

Publications

To view my publications, please use the links below:

2008 - 2010 2011 - 2012 2013

Research

The group focuses on two areas of research connected with the development and maintenance of B-cell malignancies. Firstly the role of the microenvironment in driving survival and proliferation of chronic lymphocytic leukaemia. We have found that increased protein synthesis and cap-complex formation are features of leukaemic cells supported in vitro by culture systems that mimic the microenvironment and we are exploiting this to evaluate novel small molecule inhibitors of cap-dependent translation. Secondly we are working on signaling pathways repressed by BCL6, an oncogene that is constitutively expressed in about 40% of diffuse large B-cell lymphoma.

Understanding these pathways is important to determine how lymphoma cells survive in the absence of BCL6. BCL6 itself is a target for therapy and in collaboration with the Department of Structural Biology (Leicester) and the Department of Medicinal Chemistry (Leeds) we are developing a structure activity relationship for potential small molecule BCL6 inhibitors.

Clinical trials

I am co-investigator on numerous trials for low grade and high grade non-Hodgkin's lymphomas and chronic lymphocytic leukaemia.

Current grants

The Kay Kendall Leukaemia Fund - £157,301
The CD40 miRNA signature in chronic lymphocytic leukaemia
2010 - 2013

Leukaemia and Lymphoma Research Fund - £204,073
Targeting translation in chronic lymphocytic leukaemia
2012 - 2015

Supervision

I am supervising one PhD student at present and an MSc student.

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NEWS

Congratulations from the LCRC to the following postgraduate student(s) who successfully defended their PhD Viva's recently:

Sam Khan
Rebecca Allchin
Constantinos Alexandrou
Nabil Jaunbocus

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Well done to Rachel Norman who was awarded a travel grant whilst at the Human Proteome Organization Conference in Florida, US.

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

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