Catrin Pritchard

Personal Details

Prof. Pritchard

Director of Leicester Cancer Research Centre

Tel: 0116 229 7061

Email: cap8@le.ac.uk

Career

  • 1983-1987: PhD at the Imperial Cancer Research Fund.
  • 1987-1990: Postdoctoral Fellow, University of California, San Francisco, USA.
  • 1991-1995: Postdoctoral Fellow, DNAX Research Institute, Palo Alto, California, USA.
  • 1995-2003: Royal Society Research University Research Fellow, University of Leicester.
  • 2003-2004: Lecturer, Department of Biochemistry, University of Leicester.
  • 2004-2009: Reader, Department of Biochemistry, University of Leicester.
  • 2009: Professor of Cancer Biochemistry, University of Leicester.
  • 2010-2015: Royal Society-Wolfson Research Merit Award Holder
  • 2014-2017: Science Director Cancer Research UK Leicester Centre
  • 2014-present: Head of Leicester Cancer Research Centre, University of Leicester

Publications

Recent publications (since 2010)

Research

Signal transduction through the RAF-MEK-ERK pathway

  •  Feedback control of the RAF-MEK-ERK pathway in normal and cancer cells.
  • Subcellular localisation of wild-type and oncogenic RAF isoforms.
  • Role of phosphorylation in control of RAF activity and RAF protein stability.

RAS and RAF-driven tumour development

  • RAS and RAF conditional knockin mouse models for modeling human cancer initiation and progression focusing on lung adenocarcinoma and colorectal cancer models.
  • Investigation of the role of Glycogen Synthase Kinase 3 (GSK3) in V600EBRAF-driven colorectal cancer development using mouse models.
  • Characterisation of the microenvironment of premalignant lesions driven in the lung using mouse models and human tumour tissue microarrays.
  • Cholesterol metabolism in tumour associated macrophages (TAMs) and targeting of TAMs by cholesterol modulating agents.

Novel ex vivo tumour explant platform for drug discovery and development

  • Optimisation of conditions for ex vivo tumour explant culture for a range of human cancers
  • Application of digital pathology to the characterisation and quantitation of tumour explant drug responses.
  • Derivation of patient-relevant data on drug responses correlated with predictive and pharmacodynamic biomarkers.
  • Collaborations and contracts with commercial partners to extend the application of the explant platform to the drug development pipeline.

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NEWS

Inaugural Lecture

Prof DJL Jones

6.00pm 9/10/17

Details

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“Congratulations to Dr Ni Ni Moe Myint for successfully defending her PhD thesis on the 25th August 2017. Well done from all the students and staff of the Leicester Cancer Research Centre.”

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“All the staff in the Department of Cancer Studies, wish to send their congratulations to Dr Mehdi Masood who passed his MD on 30th June 2017.  Well done!”

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Congratulations to Dr Hussein Abbas on passing his PhD on 21st June 2017.  Well done from all the staff in the Department of Cancer Studies

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

Maps and Directions

Sat Nav users: 
LE1 5WW 

Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.