Catrin Pritchard

Personal Details

Prof. Pritchard

Deputy Director of Leicester Cancer Research Centre

Tel: 0116 229 7061

Email: cap8@le.ac.uk

Career

  • 1983-1987: PhD at the Imperial Cancer Research Fund.
  • 1987-1990: Postdoctoral Fellow, University of California, San Francisco, USA.
  • 1991-1995: Postdoctoral Fellow, DNAX Research Institute, Palo Alto, California, USA.
  • 1995-2003: Royal Society Research University Research Fellow, University of Leicester.
  • 2003-2004: Lecturer, Department of Biochemistry, University of Leicester.
  • 2004-2009: Reader, Department of Biochemistry, University of Leicester.
  • 2009: Professor of Cancer Biochemistry, University of Leicester.
  • 2010-2015: Royal Society-Wolfson Research Merit Award Holder
  • 2014-2017: Science Director Cancer Research UK Leicester Centre
  • 2014-2018: Head of Leicester Cancer Research Centre, University of Leicester
  • 2018-present Deputy Director Cancer Research Centre, University of Leicester

Publications

Recent publications (since 2010)

Research

Signal transduction through the RAF-MEK-ERK pathway

  •  Feedback control of the RAF-MEK-ERK pathway in normal and cancer cells.
  • Subcellular localisation of wild-type and oncogenic RAF isoforms.
  • Role of phosphorylation in control of RAF activity and RAF protein stability.

RAS and RAF-driven tumour development

  • RAS and RAF conditional knockin mouse models for modeling human cancer initiation and progression focusing on lung adenocarcinoma and colorectal cancer models.
  • Investigation of the role of Glycogen Synthase Kinase 3 (GSK3) in V600EBRAF-driven colorectal cancer development using mouse models.
  • Characterisation of the microenvironment of premalignant lesions driven in the lung using mouse models and human tumour tissue microarrays.
  • Cholesterol metabolism in tumour associated macrophages (TAMs) and targeting of TAMs by cholesterol modulating agents.

Novel ex vivo tumour explant platform for drug discovery and development

  • Optimisation of conditions for ex vivo tumour explant culture for a range of human cancers
  • Application of digital pathology to the characterisation and quantitation of tumour explant drug responses.
  • Derivation of patient-relevant data on drug responses correlated with predictive and pharmacodynamic biomarkers.
  • Collaborations and contracts with commercial partners to extend the application of the explant platform to the drug development pipeline.

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NEWS

Powerful pre-clinical platform for anti-cancer drug and biomarker discovery

Pre-clinical models that can accurately predict outcomes in the clinic are much sort after in the field of cancer drug discovery and development.  Read about how patient derived explants offer many advantages and are the powerful model of choice. A copy of the review, published in the British Journal of Cancer, is available by clicking this link: PDE Platform

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SEND Study Success

Congratulations to Chris Avery, who with collaborating colleagues published findings of the SEND study, a multi-centre randomised trial using two different surgical protocols for mouth cancer treatment.  A nationwide first for this type of trial, using real-world data.  The paper, published in the British Journal of Cancer, is available by clicking this link: SEND Paper

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Robert Kilpatrick Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

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Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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