Catrin Pritchard

Personal Details

Prof. Pritchard

Deputy Director of Leicester Cancer Research Centre

Tel: 0116 229 7061

Email: cap8@le.ac.uk

Career

  • 1983-1987: PhD at the Imperial Cancer Research Fund.
  • 1987-1990: Postdoctoral Fellow, University of California, San Francisco, USA.
  • 1991-1995: Postdoctoral Fellow, DNAX Research Institute, Palo Alto, California, USA.
  • 1995-2003: Royal Society Research University Research Fellow, University of Leicester.
  • 2003-2004: Lecturer, Department of Biochemistry, University of Leicester.
  • 2004-2009: Reader, Department of Biochemistry, University of Leicester.
  • 2009: Professor of Cancer Biochemistry, University of Leicester.
  • 2010-2015: Royal Society-Wolfson Research Merit Award Holder
  • 2014-2017: Science Director Cancer Research UK Leicester Centre
  • 2014-2018: Head of Leicester Cancer Research Centre, University of Leicester
  • 2018-present Deputy Director Cancer Research Centre, University of Leicester

Publications

Recent publications (since 2010)

Research

Signal transduction through the RAF-MEK-ERK pathway

  •  Feedback control of the RAF-MEK-ERK pathway in normal and cancer cells.
  • Subcellular localisation of wild-type and oncogenic RAF isoforms.
  • Role of phosphorylation in control of RAF activity and RAF protein stability.

RAS and RAF-driven tumour development

  • RAS and RAF conditional knockin mouse models for modeling human cancer initiation and progression focusing on lung adenocarcinoma and colorectal cancer models.
  • Investigation of the role of Glycogen Synthase Kinase 3 (GSK3) in V600EBRAF-driven colorectal cancer development using mouse models.
  • Characterisation of the microenvironment of premalignant lesions driven in the lung using mouse models and human tumour tissue microarrays.
  • Cholesterol metabolism in tumour associated macrophages (TAMs) and targeting of TAMs by cholesterol modulating agents.

Novel ex vivo tumour explant platform for drug discovery and development

  • Optimisation of conditions for ex vivo tumour explant culture for a range of human cancers
  • Application of digital pathology to the characterisation and quantitation of tumour explant drug responses.
  • Derivation of patient-relevant data on drug responses correlated with predictive and pharmacodynamic biomarkers.
  • Collaborations and contracts with commercial partners to extend the application of the explant platform to the drug development pipeline.

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NEWS

Congratulations to all of the MPTC MSc 2017-18 graduating students; in particular to Lilas Al Boushi who was awarded the Sydney King Prize as the best performing student.

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The LCRC would like to say a huge “Congratulations” to Sam Khan, Bethan Rogoyski and Sarah Whelan, who scooped a plethora of awards at the 42nd Annual UKEMS Meeting held in Oxford from 2-5th September 2018.  Sam won best oral presentation for "targeting cancer stem-like cells in colorectal cancer" and Bethan and Sarah won young scientist poster awards for "From anti-helminth to anti-cancer: repurposing drugs to prevent mesothelioma" and "Harnessing the link between BRAF-mediated tumourigenesis and metabolism in colorectal cancer", respectively.  WELL DONE ALL!

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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All the staff and students in the LCRC extend their congratulations to Bethan Rogoyski and Sam Khan for being awarded travel bursaries from UKEMS and Health Education England respectively so they could attend the Cancer Prevention Conference in Germany.

Bethan presented her poster entitled “From Asbestos to Zinc – Can We Prevent Mesothlioma Using Repurposed Drugs?”

Sam presented her work on TBS2017-122-SK - "Targeting Nanog in colorectal tissue explant models for the evaluation of cancer prevention agents"

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Congratulations from the LCRC to the following postgraduate student(s)

Saraa Barsoom on passing her viva  and being awarded her PhD on 16th August 2018

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Tumour analysis following surgery could provide breakthrough in predicting how well cancer patients respond to drug treatment

Details here

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.