Catrin Pritchard

Personal Details

Prof. Pritchard

Director of Leicester Cancer Research Centre

Tel: 0116 229 7061

Email: cap8@le.ac.uk

Career

  • 1983-1987: PhD at the Imperial Cancer Research Fund.
  • 1987-1990: Postdoctoral Fellow, University of California, San Francisco, USA.
  • 1991-1995: Postdoctoral Fellow, DNAX Research Institute, Palo Alto, California, USA.
  • 1995-2003: Royal Society Research University Research Fellow, University of Leicester.
  • 2003-2004: Lecturer, Department of Biochemistry, University of Leicester.
  • 2004-2009: Reader, Department of Biochemistry, University of Leicester.
  • 2009: Professor of Cancer Biochemistry, University of Leicester.
  • 2010-2015: Royal Society-Wolfson Research Merit Award Holder
  • 2014-2017: Science Director Cancer Research UK Leicester Centre
  • 2014-present: Head of Leicester Cancer Research Centre, University of Leicester

Publications

Recent publications (since 2010)

Research

Signal transduction through the RAF-MEK-ERK pathway

  •  Feedback control of the RAF-MEK-ERK pathway in normal and cancer cells.
  • Subcellular localisation of wild-type and oncogenic RAF isoforms.
  • Role of phosphorylation in control of RAF activity and RAF protein stability.

RAS and RAF-driven tumour development

  • RAS and RAF conditional knockin mouse models for modeling human cancer initiation and progression focusing on lung adenocarcinoma and colorectal cancer models.
  • Investigation of the role of Glycogen Synthase Kinase 3 (GSK3) in V600EBRAF-driven colorectal cancer development using mouse models.
  • Characterisation of the microenvironment of premalignant lesions driven in the lung using mouse models and human tumour tissue microarrays.
  • Cholesterol metabolism in tumour associated macrophages (TAMs) and targeting of TAMs by cholesterol modulating agents.

Novel ex vivo tumour explant platform for drug discovery and development

  • Optimisation of conditions for ex vivo tumour explant culture for a range of human cancers
  • Application of digital pathology to the characterisation and quantitation of tumour explant drug responses.
  • Derivation of patient-relevant data on drug responses correlated with predictive and pharmacodynamic biomarkers.
  • Collaborations and contracts with commercial partners to extend the application of the explant platform to the drug development pipeline.

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Tumour analysis following surgery could provide breakthrough in predicting how well cancer patients respond to drug treatment

Details here

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New: Wellcome Trust Institutional Strategic Support Fund

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

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