Lynne Howells

Position: Research Fellow/Experimental Cancer Medicine Centre Lab Quality Manager
Location: RKCSB
Contact Details: lh28@le.ac.uk

We are jointly funded by CRUK and the Department of Health, as part of the Leicester CRUK Experimental Cancer Medicine Centre (ECMC). The remit of the ECMC is to initiate early-phase oncology-based clinical trials, based on in-house-generated pre-clinical data. Areas of research interest include generation of in vitro, in vivo and ex vivo data pertinent to Chemoprevention  across a variety of pathologies including colorectal, lung and pancreatic cancer. My research has a strong translational element, with the ultimate goal to expedite the inception of clinical pilot studies investigating chemopreventive agents/potential efficacy biomarkers of interest. Further details can be found in the listed publications. (*=corresponding author).

Methods/Techniques

Ethics submissions; Quality management programmes; Research Governance; Lab management; 3D cell culture; Primary cell culture; Explant culture; Flow cytometry and cell sorting; Standard lab techniques

Publications

  1. J Haqq, *LM Howells, G Garcea, AR Dennison. Targeting pancreatic cancer using a combination of gemcitabine with the omega-3 polyunsaturated fatty acid emulsion, Lipidem™. Accepted Molecular Nutrition and Food Research. 11/2015.
  2. *Lynne Howells, Karen Brown. Colorectal Cancer Chemoprevention. In Encyclopedia of Cancer 10/2015. Edited by Manfred Schwab. Published by SpringerVerlag.
  3. MI. James, C Iwuji, G Irving, A Karmokar, JA. Higgins, N Griffin-Teal, A Thomas, P Greaves, H Cai, SR. Patel, B Morgan , A Dennison, M Metcalfe, G Garcea, DM. Lloyd, DP. Berry, WP. Steward, *LM Howells, K Brown. Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy. Cancer Letters 2015; 364(2).
  4. E Scott, H Cai, A Kholghi, C Andreadi, A Rufini, A Karmokar, RG. Britton, E Horner-Glister, P Greaves, D Jawad, M James, L Howells, T Ognibene, M Malfatti, C Goldring, N Kitteringham, M Viskaduraki, K West, A Miller, D Hemingway, WP. Steward, AJ. Gescher and K Brown. Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice. Science Translational Medicine 2015; 7(298):298ra117.
  5. CUFK Hill, SEA Saad, RG Britton, AJ Gescher, S Sale, K Brown, *LM Howells. Inhibition of Prostate Cancer Cell Growth by 3ʹ, 4ʹ, 5ʹ-Trimethoxyflavonol (TMFol). Cancer Chemotherapy and Pharmacology 2015; 76(1).
  6. GRB Irving, C Iwuji, B Morgan, DP Berry, WP Steward, A Thomas, K Brown, *LM Howells. Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial. Trials 2015; 16(1).
  7. MI. James, *LM Howells, A Karmokar, JA. Higgins, P Greaves, H Cai, A Dennison, M Metcalfe, G Garcea, D Lloyd, DP. Berry, WP Steward, K Brown. Propagation of cancer stem-like cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. PLoS ONE 2015; 10(2):e0117776.
  8. F Runau, A Arshad, J Isherwood, Norris, L Howells, M Metcalf, A Dennison. Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: applications in pancreatic cancer. Nutrition in Clinical Practice 2015; 30(3).
  9. J Mahale, G Smagurauskaite, K Brown, A Thomas, *LM Howells. The role of stromal fibroblasts in lung carcinogenesis: a target for chemoprevention? International Journal of Cancer 2015; 138(1).
  10. J Haqq, LM Howells, G Garcea, M Metcalfe, W Steward, A Dennison. Pancreatic stellate cells and pancreatic cancer: Current perspectives and future strategies. European Journal of Cancer 2014; 50(15).
  11. C Iwuji, *L Howells,  K Brown, W Steward, J Barwell, A Thomas. Cancer Chemoprevention: factors influencing attitudes towards chemopreventive agents in high risk populations. European Journal of Cancer Prevention. 23(6) 594-601 2014.
  12. *LM Howells, J Mahale, S Sale, L McVeigh, WP. Steward, A Thomas, K Brown. Translating curcumin to the clinic for lung cancer prevention: evaluation of the pre-clinical evidence for its utility in primary, secondary and tertiary prevention strategies. Journal of Pharmacology and Experimental Therapeutics 2014; 350(3).
  13. G Irving, L Howells, S Sale, I Kralj-Hans, W Atkin, S Clark, R Britton, D Jones, E Scott, D Berry, D Hemingway, A Miller, K Brown, A Gescher, and W Steward. Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration - a clinical pilot study including assessment of patient acceptability. Cancer Prevention Research. 6:119-128. 2013.
  14. D. Al-Leswas, W.-Y. Chung, L Howells, A. Eltweri, A. Arshad, C. Pollard, G. Garcea, M. Metcalfe, A. Dennison. The effects of omega-3 fish oil infusion on the T-regulatory cells in patients with severe acute pancreatitis: A randomised control pilot study. Pancreatology. 13(1):e13-e14. 2013.
  15. LM Howells, DP. Berry, PJ. Elliott, EW. Jacobson, E Hoffmann, B Hegarty, K Brown, WP. Steward, AJ. Gescher. Phase I randomised double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases – safety, pharmacokinetics and pharmacodynamics. Cancer Prevention Research. 4(9), 1419-1425. 2011.

Links

www.le.ac.uk/lcrc
http://www.ecmcnetwork.org.uk/

Collaborators

University Hospitals of Leicester NHS Trust
Hope Clinical Trials Unit, Leicester
Indena SpA, Milan, Italy
ProCURE (Program Against Cancer Therapeutic Resistance, Catalan Institute of Oncology (ICO), Spain.
Sirtris (A GSK company)

Funders

Cancer Research UK/Department of Health
Hope Against Cancer
Indena SpA

Teaching Skills/Experience

Currently applying for FHEA

Other Relevant Activities

Undertaking Level 3 qualification in Leadership and Management via ILM

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Robert Kilpatrick Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

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