Professor Karen Brown

Professor of Translational Cancer ResearchKaren Brown

Contact details

  • Tel: +44 (0)116 223 1851
  • Email: kb20@le.ac.uk
  • Office: CSMM, Level 5 Offices, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE1 5WW

Personal details

B.Pharm, MRPharmS, PhD

As Professor of Translational Cancer Research, I work in the Department of Cancer Research at the University of Leicester.

Publications

Hong Cai, Edwina Scott, Abeer Kholghi, Catherine Andreadi, Alessandro Rufini, Ankur Karmokar, Robert G. Britton, Emma Horner-Glister, Peter Greaves, Dhafer Jawad, Mark James, Lynne Howells, Ted Ognibene, Michael Malfatti, Christopher Goldring, Neil Kitteringham, Joanne Walsh, Maria Viskaduraki, Kevin West, Andrew Miller, David Hemingway, William P. Steward, Andreas J. Gescher and Karen Brown. Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Science Translational Medicine  29 Jul 2015: Vol. 7, Issue 298, pp. 298ra117

Abstract link

Reprint link

Full list of publications

Research

Preclinical and early clinical development of novel cancer chemopreventive agents

  • Development of resveratrol, curcumin and anthocyanins.
  • Determining optimal intervention schedules – investigation of dose-response relationships for dietary and pharmacological doses of chemopreventive agents.
  • Development of long-term in vitro models for screening agents.
  • Application and evaluation of human stem cells as novel in vitro/in vivo approaches for assessing efficacy of chemopreventive agents.
  • Combining dietary chemopreventive agents with chemotherapeutic regimens for the treatment of cancer.

Identification and development of novel biomarkers of cancer risk, prognosis and chemopreventive/chemotherapeutic agent efficacy

  • Development of novel, sensitive and specific techniques for biomarker analysis (particularly LC-MS/MS and accelerator mass spectrometry based methods).
  • Assessment of DNA damage (global and specific lesions) as a biomarker of efficacy for chemopreventive agents and chemotherapeutic drugs in humans.
  • Determining the mechanisms of tamoxifen carcinogenesis in women and the role of tamoxifen DNA adduct formation in human tissues.
  • Assessing the biological significance of DNA damage induced by occupational/environmental exposure to the carcinogen ethylene oxide.
  • Development of novel, biomarker driven strategies towards personalized treatment of Chronic Lymphocytic Leukaemia.

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NEWS

Congratulations from the LCRC to the following postgraduate student(s) who successfully defended their PhD Viva's recently:

Sam Khan
Rebecca Allchin
Constantinos Alexandrou
Nabil Jaunbocus

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Well done to Rachel Norman who was awarded a travel grant whilst at the Human Proteome Organization Conference in Florida, US.

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

DisabledGo logo

The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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