Publications 2005 - 2008

2005 

  1. Pollard, P. J., Brière, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Tomlinson, I. P. (2005, August 8). Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.. Human Molecular Genetics, 14(15), 2231-2239. doi:10.1210/jc.2006-0920 
  2. Pollard, P. J., Brière, J. J., Alam, N. A., Barwell, J., Barclay, E., Wortham, N. C., Tomlinson, I. P. (2005, August 1). Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.. Hum Mol Genet, 14(15), 2231-2239. doi:10.1093/hmg/ddi227 
  3. Barwell, J., Mazzaschi, R., Bint, S., Elmslie, F., & Mackie Ogilvie, C. (2005). A new neocentromere locus on chromosome 13 resulting in mosaic tetrasomy for distal 13q and an asymmetric phenotype.. American Journal of Medical Genetics, 3, 295-298. 
  4. Leegte, B., van der Hout, A. H., Deffenbaugh, A. M., Bakker, M. K., Mulder, I. M., ten Berge, A., Oosterwijk, J. C. (2005). Phenotypic expression of double heterozygosity for BRCA1 and BRCA2 germline mutations.. Journal of Medical Genetics, 42(3), e20. doi:10.1136/jmg.2004.027243 

2006

  1. Brinkman, H., Barwell, J., Rose, S., Tinworth, L., Sodha, N., Langman, C., Hodgson, S. (2006). Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility. Clinical Genetics, 70(6), 526-529. doi:10.1111/j.1399-0004.2006.00711.x 
  2. Pollard, P. J., El Bahrawy, M., Poulsom, R., Elia, G., Killick, P., Kelly, G., Maher, E. R. (2006). Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. Journal of Clinical Endocrinology and Metabolism, 91(11), 4593-4598. 
  3. Geary, J., Thomas, H. J., Mackay, J., Dorkins, H., Barwell, J., & Hodgson, S. V. (2006). The management of families affected by hereditary non-polyposis colon cancer (HNPCC). Familial Cancer, 6(1), 13-9. doi:10.1007/s10689-006-9000-4 

2007

  1. Barwell, J., Pangon, L., Georgiou, A., Docherty, Z., Kesterton, I., Ball, J., Hodgson, S. (2007, December 17). Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?. Br J Cancer, 97(12), 1696-1700. doi:10.1038/sj.bjc.6604085 
  2. Barwell, J., Pangon, L., Georgiou, A., Kesterton, I., Langman, C., Arden Jones, A., Hodgson, S. V. (2007, October 10). Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility. International Journal of Cancer, 121(7), 1631-1636. 
  3. Barwell, J., Pangon, L., Hodgson, S. V., Georgiou, A., Kesterton, I., Slade, T., Morris, J. R. (2007, August 8). Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics.. Journal of Medical Genetics, 44(8), 516-520. 
  4. Barwell, J., Pangon, L., Hodgson, S. V., Georgiou, A., Kesterton, I., Slade, T., Morris, J. R. (2007). Cellular phenotype in MSH2 homozygous mutation carrier. Journal of Medical Genetics, 44, 516-520. doi:10.1136/jmg.2006.048660 
  5. Barwell, J., Pangon, L., Georgiou, A., Kesterton, I., Langman, C., Arden Jones, A., Hodgson, S. V. (2007). Chromosome breakage in BRCA1 and BRCA2 mutation carriers. International Journal of Cancer, 12, 1631-1636. 
  6. Georgiou, A., Docherty, Z., Langman, C., Kesterton, I., Rose, S., Camplejohn, R., Hodgson, S. V. (2007, January 1). Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer susceptibility?. International Journal of Radiation Biology, 83(1), 1-12.
  7. Barwell, J., Pangon, L., Georgiou, A., Docherty, Z., Kesterton, I., Ball, J., Hodgson, S. V. (2007). Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?. British Journal of Cancer, 97, 696-700.
  8. Douglas, J., Cilliers, D., Coleman, K., Tatton-Brown, K., Barker, K., Rahman, N., Zankl, A. (2007, August). Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. Nature Genetics, 39(8), 963-965. doi:10.1038/ng2083

2008

  1. Barwell, J. (2008). Cancer Genomics 2007 Hum Genet 123:433.  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Congratulations from the LCRC to Bethan Rogoyski and Aleksandra Bzura.

Bethan won best oral presentation at the AMS Midlands Academy of Medical Sciences Festival held on 27th March 2019 for her presentation on "Redeployment: The potential of repurposed drugs in preventing mesothelioma".

Aleks won the University PGR poster fair competition on 18th March 2019 for her poster entitled "New hope for treating mesothelioma cancer using PARP inhibitors".

Also, a huge well done to Grandezza Aburido who was in the semi-finals of the PGR poster fair.  

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Congratulations to Noura Alibrahim who passed her PhD viva recently.  Well done!

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

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