Dr John Le Quesne



Senior Lecturer (University of Leicester)Dr J Le Quesne
Programme leader (MRC Toxicology Institute)
Diagnostic thoracic histopathologist

Contact details

Tel: +44 (0)116 2525541
Email: jlq2@le.ac.uk
Office: Hodgkin Building, Lancaster Road, Leicester LE1 9HN

Personal details

MA, PhD, MB, BS,

I am Senior Lecturer at the University of Leicester and also Programme Leader and Diagnostic Thoracic Histopathologist. I have Specialist training in histopathology at University Hospitals Leicester, Addenbrooke’s hospital Cambridge, Royal Brompton Hospital Chelsea, Papworth. I am Hospital Fellow of the Royal College of Pathologists.




MA Natural Sciences, Cambridge University
PhD (molecular biology), Universtiy of Leicester
MB BS, St Bartholomew’s and the Royal London School of Medicine
Specialist training in histopathology: University Hospitals Leicester, Addenbrooke’s hospital Cambridge, Royal Brompton Hospital Chelsea, Papworth Hospital
Fellow of the Royal College of Pathologists

NHS work

Diagnostic lung histopathology and cytopathology


Tissue-based research
Lung cancer and mesothelioma biology
Improved diagnostic testing from FFPE tissue
Mechanistic toxicology of cancer therapy
Use of archival tissues for biomarker discovery
Molecular biology of early lung malignancy
Cell biological interpretation of tumour morphology and cytology
Large-scale tissue microarray construction and exploitation
Translational dysregulation as a predictive biomarker
Digital pathology and in silico image analysis/morphometry

Cell biology and biochemistry
mRNA helicases and translational control
Ameliorating toxicity of cancer therapies
Translational dysregulation and the malignant phenotype
Intratumoural competition
Pharmaceutical targeting of mRNAs as cancer therapy

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SEND Study Success

Congratulations to Chris Avery, Honorary Associate Professor and Consultant Maxillofacial Surgeon, who with collaborating colleagues published the findings of the significant SEND study, a multi-centre randomised trial using two different surgical protocols for  mouth cancer treatment.  A nationwide first for this type of trial, using real-world data.  The paper, published in the British Journal of Cancer, is available by clicking this link: SEND Paper


Congratulations from the LCRC to Bethan Rogoyski and Aleksandra Bzura.

Bethan won best oral presentation at the AMS Midlands Academy of Medical Sciences Festival held on 27th March 2019 for her presentation on "Redeployment: The potential of repurposed drugs in preventing mesothelioma".

Aleks won the University PGR poster fair competition on 18th March 2019 for her poster entitled "New hope for treating mesothelioma cancer using PARP inhibitors".

Also, a huge well done to Grandezza Aburido who was in the semi-finals of the PGR poster fair.


New: Wellcome Trust Institutional Strategic Support Fund



Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

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