Dr David Guttery

Lecturer in Cancer Early Detection

 Dr David GutteryRoom 334, Level 3, Robert Kilpatrick Clinical Sciences Building
Leicester Royal Infirmary
Leicester LE2 7LX
Tel: +44 (0)116 252 3181
Email: dsg6@le.ac.uk


Personal details

1999-2003: BSc (Hons) in Medicinal Biochemistry, University of Wolverhampton
2004-2005: MSc in Molecular Pathology and Toxicology, University of Leicester
2005-2008: PhD in Molecular Breast Pathology, University of Leicester
2008-2009: Post-Doctoral Scientist - MRC Toxicology Unit, University of Leicester
2009-2010: Research Associate - Dept. of Cancer Studies and Molecular Medicine, University of Leicester
2010-2012: Research Fellow - Centre for Genetics and Genomics, University of Nottingham
2012-2017: Senior Research Associate – Dept. of Cancer Studies, University of Leicester
2017-present: Lecturer in Cancer Early Detection - Dept. of Cancer Studies, University of Leicester

Publications

You can view my publications here.

Research interests

My research interests are intertwined with those of Professor Jacqui Shaw (see Professor Jacqui Shaw's webpage), which focus on the utility of circulating nucleic acids and other circulating biomarkers for early detection and monitoring of cancer. I am currently a co-investigator on an integrated, collaborative programme of clinical and translational research between the University and Leicester and Imperial College funded by Cancer Research UK. As part of this programme, my specific interests include:

  1. Development of next-generation sequencing methods for utility in liquid biopsies
  2. Analysis of novel circulating biomarkers for early detection and monitoring of breast cancer

Complementing this, my research is focused on the utility of these methods for early detection and monitoring of endometrial cancer, the incidence of which is increasing annually. A specific focus is on:

  1. Molecular methods for early detection and monitoring of endometrial cancer
  2. Molecular profiles of endometrial cancers from different ethnic groups

Illustration 1

Our group has been pioneering in development and utilisation of next-generation sequencing methods for early detection and monitoring of cancer. We have recently highlighted the importance of copy number aberrations AND somatic mutations in cfDNA for real-time monitoring of tumour evolution and acquired resistance to aromatase inhibitors by next-generation sequencing (see above figure), as well as showing that cfDNA profiles mirror the heterogeneity observed in single circulating tumour cells (see figure below)

Illustration 2

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NEWS

SEND Study Success

Congratulations to Chris Avery, Honorary Associate Professor and Consultant Maxillofacial Surgeon, who with collaborating colleagues published the findings of the significant SEND study, a multi-centre randomised trial using two different surgical protocols for  mouth cancer treatment.  A nationwide first for this type of trial, using real-world data.  The paper, published in the British Journal of Cancer, is available by clicking this link: SEND Paper

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Congratulations from the LCRC to Bethan Rogoyski and Aleksandra Bzura.

Bethan won best oral presentation at the AMS Midlands Academy of Medical Sciences Festival held on 27th March 2019 for her presentation on "Redeployment: The potential of repurposed drugs in preventing mesothelioma".

Aleks won the University PGR poster fair competition on 18th March 2019 for her poster entitled "New hope for treating mesothelioma cancer using PARP inhibitors".

Also, a huge well done to Grandezza Aburido who was in the semi-finals of the PGR poster fair.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

AccessAble logo

The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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