Dr Alessandro Rufini

Lecturer in Cancer Chemoprevention

Room 542, Level 5, Robert Kilpatrick Clinical Sciences Building
Leicester Royal Infirmary
Leicester LE2 7LX

Tel: +44 (0)116 252 3127

Fax: +44 (0)116 223 1855

Email: ar230@le.ac.uk

Personal details

  • BSc (Hons) (University of Rome La Sapienza)
  • PhD Universities of Calabria Consenza and Rome Tor Vergata

Research

Our group aims at combining basic and clinical research to improve current strategies and design new approaches to cancer prevention.

Our work spans within three different research subjects:

  1. Dissecting the mechanism(s) of action of available chemopreventive agents such as aspirin and resveratrol.
  2. Investigating early stages of carcinogenesis to identify new potential targets for cancer prevention. In particular, we are interested in metabolic changes affecting early stages of neoplasia that might be exploited to design dietary or chemopreventive interventions.
  3. Finally, since the implementation of cancer preventive strategies relies on the availability of biomarkers for accurate, long-term follow-up, we are currently investigating the use of circulating-free DNA as biomarkers for cancer prevention.

To achieve these aims, we use mouse models of colorectal cancer (CC) based on inducible mutations of theproto-oncogenee Braf or the tumour suppressor Apc. These mice are pre-clinical models of CC with a striking similarity to the human disease. They also represent source for in-vitro intestinal organoids culture. These organoids grow three-dimensionally in matrigel and recapitulate the intestinal crypt-villus morphology, encompassing all cellular lineages. We can, therefore, treat the organoids with cancer preventive agents and study the morphological and physiological outcomes of treatments.

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NEWS

Congratulations from the LCRC to the following postgraduate student(s) who successfully defended their PhD Viva's recently:

Sam Khan
Rebecca Allchin
Constantinos Alexandrou
Nabil Jaunbocus

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Well done to Rachel Norman who was awarded a travel grant whilst at the Human Proteome Organization Conference in Florida, US.

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In a recent exercise undertaken by the NCRI’s Clinical and Translational Radiotherapy Research Working Group (CTRad) Leicester was rated as internationally competitive/leading in the Radiation Biology Research domain, one of just four centres in the UK to achieve this rating in that domain.

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New: Wellcome Trust Institutional Strategic Support Fund

Details

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Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair jm65@le.ac.uk

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170
E: cancerstudies@le.ac.uk

(Please note this email address should not be used for clinical referrals or patient correspondence)

Maps and Directions

Sat Nav users: 
LE1 5WW

Accessibility

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The University of Leicester is committed to equal access to our facilities. DisabledGo has a detailed accessibility guide for the Robert Kilpatrick Clinical Sciences Building.

Seminars

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