Professor G Don Jones

Professor of Cancer Radiation Research

Deputy Director, Leicester Cancer Research Centre

Fellow of the Higher Education Academy

Contact Details

Office: Room 1.26A, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX

Tel: +44 (0)116 223 1841



The interests of my research team (the Radiation and Oxidative Stress group) may be summarised as: ‘Mechanisms, Measurement, Enhancement and Consequences of Radiogenic, Oxidative and Drug-Induced Damage to DNA’.

Radiotherapy and chemotherapy used either singly or in combination, are two of the principal modalities for the treatment of cancer. For radiation and many chemotherapeutic drugs, genomic DNA is the primary cellular target for the biological effects of these agents; indeed it is the DNA damage induced which is thought to be responsible for killing the of the cancer cells.

To better understand, judge and improve treatment efficacy, the purpose of our research is to explore the mechanisms to enhance these damaging interactions and to develop methods and biomarkers for the accurate measurement of DNA damage in vitro and in vivo; Importantly, we consider that assessing a biologically significant end-point (DNA damage formation and repair), which takes into account many of the governing molecular and genetic factors, offers the best chance of assessing, predicting and enhancing a patient's response to treatment. Emphasis is placed on studying clinically relevant doses (avoiding the uncertainty of extrapolation from higher doses) and on translational research themes with anticipated patient benefit.


You can view my publications on PubMed Publication Listing.


  • BSc (Hons), Chemistry with Biochemistry, University of Leicester (1982)
  • MSc (Carbohydrate Chemistry - by research), University of Birmingham (1984)
  • PhD (Radiation Chemistry), University of Leicester (1987)
  • Postdoctoral Research Scientist, MRC Radiobiology Unit, Chilton, Didcot, Oxon (1987‐1991)
  • Postdoctoral Research Scientist, Division of Radiation Biology, Department of Radiology, University of California San Diego, La Jolla, California USA (1991-1994)
  • Visiting Research Scientist, Radiobiology Program, Cross Cancer Institute, Edmonton, Alberta Canada (1994-1995)
  • Centre Research Fellow, Centre for Mechanisms of Human Toxicity & Honorary Lecturer, Department of Chemistry, University of Leicester (1995-2000)
  • Lecturer, Department of Oncology, University of Leicester (2000-2002)
  • Senior Lecturer, Department of Oncology, University of Leicester (2002-2007)
  • Reader in Radiation Research, Department of Cancer Studies, University of Leicester (2007-2016)
  • Professor of Cancer Radiation Research, Department of Cancer Studies, University of Leicester (2016-to date)


  • Deputy Head of Department, Department of Cancer Studies, University of Leicester (2010 to date)
  • MSc Course Convenor, Molecular Pathology & Therapeutics of Cancer (MPTC) MSc, Department of Cancer Studies, University of Leicester (2014 to date)
  • Module Co-Lead, Biology of Cancer Special Study Module (BoC/SSM) (MB ChB Phase 1), Leicester Medical School, University of Leicester (2013 to date)
  • Radiation Research Lead, Cancer Research Leicester Centre & Chair, Radiation Research at Leicester Group (RR@Le), University of Leicester (2014 to date)


  • Vice-President, President & Past-President, European Radiation Research Society (2011-2012, 2013-2014 & 2015-2016)
  • Vice-President & President, Association for Radiation Research (2006-2008 & 2008-2010)
  • Council Member, International Association for Radiation - serving consecutive terms of office (2011-2015 & 2015-2019)
  • Network Lead, NCRI CTRad UK Biomarker Network (2013 to date)
  • Committee Member, NCRI Clinical & Translational Radiotherapy Research Working Group (CTRad), (Basic Science - Workstream 1), serving 3 successive terms (2009-2011, 2012-2014, 2015-2017)
  • Finance Committee Lead & Nominations Committee Member, International Association for Radiation Research (2015)
  • Honorary Member, awarded by the Royal College of Radiologists for ‘Notable contributions made to Clinical Oncology in the United Kingdom’ (2012)
  • Examiner, Royal College of Radiologists, Faculty of Clinical Oncology, for the First Examination of the Fellowship in Clinical Oncology  (2005-2011)
  • Committee Member & Trustee, LH Gray Memorial Trust (2008 to date)
  • Treasurer & Membership Secretary, Association for Radiation Research (2005-2010)
  • Editorial Board Member, the journal Mutagenesis (2006 to 2016)
  • Editorial Board Member, the journal Clinical Oncology (2006-2012) and twice Guest Editor of the Special Editions ‘Advances in Clinical Radiobiology’ Parts 1 (2013) and 2 (2014)

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All the staff and students in the LCRC extend their congratulations to Bethan Rogoyski and Sam Khan for being awarded travel bursaries from UKEMS and Health Education England respectively so they could attend the Cancer Prevention Conference in Germany.

Bethan presented her poster entitled “From Asbestos to Zinc – Can We Prevent Mesothlioma Using Repurposed Drugs?”

Sam presented her work on TBS2017-122-SK - "Targeting Nanog in colorectal tissue explant models for the evaluation of cancer prevention agents"


Congratulations from the LCRC to the following postgraduate students

Dr Panayoti Bachkangi  12th March (PhD)

Dr Sami Mamand  8th Mar (PhD)

Dr Amal Bengreed 2nd Feb (PhD)

Dr Tim Rattay  23rd Jan (PhD)

Dr Callum Rakhitt   19th Jan (PhD)

Dr John Isherwood  18th Jan (MD)

Dr Hanaa Al-Mahmoodi  12th Jan (PhD)


Tumour analysis following surgery could provide breakthrough in predicting how well cancer patients respond to drug treatment

Details here


New: Wellcome Trust Institutional Strategic Support Fund



Centre Health and Wellbeing Group
Join up for a walk on the park Friday lunchtime - details here.

More information from Jenny McNair

Contact Details

Leicester Cancer Research Centre
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 252 3170

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