Held on Monday 14 November 2011

Spin Doctoring in Rational Drug Discovery and Design

This event was held on Monday 14 November 2011 (3.00pm - 5.00pm)

There are no further dates scheduled at present.

This seminar runs for 2 hours

The discovery and development of new therapeutics will become increasingly dependent on the use of rational, knowledge-based approaches, in which detailed understanding of the structural features and properties of targeted proteins or protein complexes will play a central role, together with precise information on the binding sites and modes of interaction for novel pharmaceutical leads. The seminar will discuss the potential impact of nuclear magnetic resonance (NMR) spectroscopy-based approaches on knowledge-based drug discovery, with examples given of its application to the identification and optimisation of potential small molecule drugs, as well as illustrations of its increasing importance in the development of therapeutic antibodies.

The series is open to all academics and PhD research students across the University.

Professor Mark Carr (Dept of Biochemistry, University of Leicester)

Professor Mark Carr started his research career as a PhD student in Professor Iain Campbell’s group in the Department of Biochemistry at the University of Oxford. This was followed by structural biology postdoctoral positions at the Max Planck Institute for Medical Research in Heidelberg and the National Institute for Medical Research in London, where Dr Jim Feeney encouraged him to develop his own research projects. For several years Mark worked as a group leader at the National Institute for Biological Standards and Control, before moving to the Department of Biosciences at the University of Kent as a Lecturer where he established a new centre for NMR spectroscopy-based structural biology with substantial support from the Wellcome Trust. He was recruited to the Department of Biochemistry at Leicester in early 2001 as a Reader and continued to develop a successful research programme focussed on understanding the precise functions and molecular mechanisms of proteins and protein complexes involved in key biological processes of significant medical importance, such as tuberculosis pathogenesis and control of eukaryotic gene expression. In addition, Mark’s group has developed a very close and successful collaboration with research scientists at UCB Celltech, which promises to have a significant impact on the discovery and development of new drugs, including therapeutic antibodies.

This seminar forms part of the Intrepid Researcher series.

During this seminar the experts will speak for an hour followed by time for questions and discussion.  This is also an opportunity to meet the speaker informally over tea and cakes at the end.  

drug discovery, NMR, protein structure, therapeutic antibodies.

Maximum 60 delegates
Minimum 6 delegates

Please complete the online the Intrepid Researcher - Booking Form, submitting to the Staff Development Partnership. 

Booking conditions apply.

About the workshop content:
Contact Dr Meera Warrier (Academic Practice Unit) email: mw189@le.ac.uk  tel: (0116) 223-1876.

About the workshop arrangements:
Contact Us at the Staff Development Partnership.

SDCRSCH-SPR-IR206