Red meat metabolite levels high in acute heart failure patients, research shows
Issued by University of Leicester Press Office on 18 February 2016
An interview with Professor Toru Suzuki about the research is available here:
Patients with acute heart failure often have high levels of the metabolite trimethylamine N-oxide (TMAO) – of which red meat is a major dietary source - according to researchers from the University of Leicester.
Red meat, which has been reported to be associated with cardiovascular disease, is a source of L-carnitine which is broken down by gut bacteria to form TMAO.
In previous studies TMAO has been association with mortality risk in chronic heart failure but this association in acute heart failure is still unknown.
The team, led by Professor Toru Suzuki from the University of Leicester’s Department of Cardiovascular Sciences and PI within the Leicester Cardiovascular BRU, measured circulating TMAO levels in approximately 1,000 patients admitted to University Hospitals of Leicester NHS Trust with acute heart failure.
The study, published in the journal Heart, was the first to investigate association of TMAO levels in acute heart failure patients, a condition associated with high mortality and morbidity – and suggests involvement of the gut microbiota and diet in outcomes of acute heart failure.
This study shows an association between circulating levels of a metabolite of this process with prognosis of acute heart failure.
Professor Suzuki said: “Patients with acute heart failure showed higher levels of the oxidised metabolite TMAO in those that died or had a repeat admission to hospital with heart failure within the first year.
“Our study shows that higher levels of TMAO, a metabolite of carnitine derived from red meat, is associated with poorer outcomes associated with acute heart failure, one of the main diseases of the heart.
“This metabolic pathway provides a possible link between how red meat is associated with heart disease.”
The study, ‘Trimethylamine N-oxide and prognosis in acute heart failure’, which was supported by the John and Lucille van Geest Foundation and the National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, is available here: http://heart.bmj.com/cgi/content/full/heartjnl-2015-308826
Notes to Editors:
For more information please contact Professor Toru Suzuki firstname.lastname@example.org
The National Institute for Health Research (NIHR) is funded by the Department of Health to improve the health and wealth of the nation through research. The NIHR is the research arm of the NHS. Since its establishment in April 2006, the NIHR has transformed research in the NHS. It has increased the volume of applied health research for the benefit of patients and the public, driven faster translation of basic science discoveries into tangible benefits for patients and the economy, and developed and supported the people who conduct and contribute to applied health research. The NIHR plays a key role in the Government’s strategy for economic growth, attracting investment by the life-sciences industries through its world-class infrastructure for health research. Together, the NIHR people, programmes, centres of excellence and systems represent the most integrated health research system in the world. For further information, visit the NIHR website (www.nihr.ac.uk).
This work was conducted in affiliation with the NIHR Leicester Cardiovascular Biomedical Research Unit.