Dr Claire Gibson
Head of School
School of Psychology
University of Leicester
Leicester LE1 9HN
PhD Neuroscience (University of Newcastle)
BSc Neuroscience (University of Sheffield)
- Cerebral ischaemic stroke – mechanisms of injury and potential treatment strategies
Cerebral ischaemic stroke, in the UK, is the 3rd leading cause of mortality, 1st leading cause of morbidity and estimated to cost the NHS £2.8 bn per annum in direct costs. There is a real need for basic research to identify potential neuroprotective strategies in order to determine whether clinical investigation is warranted. My lab has a long standing research interest in the role of steroid hormones as potential protective factors following ischemic stroke. Gender also influences pathology and outcome following stroke – we are also beginning to explore the gender-specific mechanisms of injury that may be relevant following ischaemic stroke.
Key mechanisms of injury following ischaemic stroke involve apoptosis and inflammation. We are investigating, in collaboration with stroke clinicians at the University of Nottingham, molecular mechanisms that may underlie the breakdown of the blood brain barrier and treatment strategies to promote its repair. In addition, in collaboration with colleagues at Leicester (Department of Cell Physiology & Pharmacology, Department of Cardiovascular Sciences) we are pursuing an interest in the role of prostaglandins and opioid receptors following ischaemic stroke.
- Experimental stroke models
In order to pursue these research questions we utilise a range of in vitro, ex vivo and in vivo experimental stroke models complimented with a number of behavioral, imaging (immunocytochemistry, MRI) and molecular biology techniques. We are also interested in the refinement of existing experimental stroke models and increasing the translational relevance of experimental data to the clinical setting. We have a current project investigating the use of structural MRI to assist in understanding the variability seen in outcome following induction of experimental stroke.
Recent publications - full list available
Trotman M, Vermehren P, Gibson CL, Fern R (2014) The dichotomy of memantine treatment for ischemic stroke; dose-dependent protective and detrimental effects. Journal of Cerebral Blood Flow & Metabolism, 35: 230-239.
Wong R, Gibson CL, Kendall D, Bath PWM (2014) Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice. BMC Neuroscience, 15:131.
Gibson CL, Srivastava K, Sprigg N, Bath PMW, Bayraktutan U (2014) Inhibition of Rho-kinase protects cerebral barrier from ischemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. Journal of Neurochemistry, 129: 816-826.
Gibson CL (2013) Cerebral ischemic stroke – is gender important? Journal of Cerebral Blood Flow & Metabolism 33: 1355-1361.
Shah DS, Prados J, Gamble J, De Lillo C, Gibson CL (2013) Sex differences in spatial memory using serial and search tasks. Behavioural Brain Research 257: 90-99.
Wong R, Hogg C, Gibson CL, Murphy S, Kendall DA, Bath PMW (2013) Progesterone treatment for experimental stroke: an individual animal meta-analysis. Journal of Cerebral Blood Flow and Metabolism 33: 1362-1372.
Wong R, Kendall D, Bath PMW, Gibson CL (2013) Progesterone and ischaemia in the ageing brain. Journal of Neuroendocrinology, 25: 1088-1094.
Akram A, Gibson CL, Grubb BD (2013) Neuroprotection mediated by the EP4 receptor avoids the detrimental side effects of COX-2 inhibitors following ischaemic injury. Neuropharmacology, 65:165-172.
Chauhan NK, Young AMJ, Gibson CL, Davidson C (2013) Inhibition of pre-ischaemic conditioning in the mouse caudate brain slice by NMDA- or adenosine A1 receptor antagonists. European Journal of Pharmacology, 698: 322-329.
Prados J, Alvarez B, Howarth J, Stewart K, Gibson CL, Hutchinson CV, Young AMJ, Davidson C (2013) Cue competition effects in the planarian. Animal Cognition, 16: 177-186.
2015-18: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) - PhD Studentship.
2015-18: British Journal of Anaesthesia - PhD Studentship (with Professor Dave Lambert, Department of Cardiovascular Sciences).
2014-15: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) - Pilot Grant.
2014: Rosetrees Foundation Award, British Society for Neuroendocrinology Project Support Award.
Funding is also gratefully acknowleged from the following: Wellcome Trust, MediSearch & University of Nottingham SandPit funds, Nuffield Foundation and Research Into Ageing.
Current lab members
Ms Melissa Trotman (Research Assistant), Ms Entisar Elsaeedi (PhD student, joint with Cell Physiology & Pharmacology).
Previous lab members: Ms Asha Akram (PhD Student), Mr Raymond Wong (visiting PhD student, University of Nottingham), Dr Ben Coomber (Research Into Ageing funded postdoc), Mr Stephen Knight (Intercalated medical student), Mr Tim Fleming (Intercalated medical student), Mr Nathan Price (Intercalated medical student), Mr Luke Attwood (Intercalated medical student).
Potential PhD Applicants: Enquiries are welcome from potential PhD students, please see: http://www2.le.ac.uk/study/research/phd/psychology/phd/phd
Links to dedicated research pages
Behavioural Neuroscience research in the School of Psychology
Neuroscience at Leicester: http://www2.le.ac.uk/projects/neuroweb