Professor Irene Gottlob

Professor Irene GottlobProfessor of Ophthalmology 

Tel: 0116 252 3268


Address: Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Level 5, Leicester Royal Infirmary, Leicester, LE2 7LX

For general enquiries, please email the secretary, Mrs Sam Kerr or telephone 0116 252 3152

Research Interests

My current research interests include:

Nystagmus Research

  • Genetic Causes of Infantile Nystagmus
  • Improved Diagnosis of Infantile Nystagmus
  • Treatment of Infantile Nystagmus

Amblyopia Research

  • Exploring Reasons for Poor Outcomes for Amblyopia Treatment
  • Improving Adherence and Optimising Treatment for Amblyopia
  • Effect of Amblyopia on Reading

Read more about Research in Ophthalmology at Leicester

Key Publications

Thomas MG, Crosier M, Lindsay S, Kumar A, Thomas S, Araki M, Talbot CJ, McLean RJ, Surendran M, Taylor K, Leroy BP, Moore AT, Hunter DG, Hertle RW, Tarpey P, Langmann A, Lindner S, Brandner M, Gottlob I. The clinical and molecular genetic features of idiopathic infantile periodic alternating nystagmus. Brain. 2011 Mar;134(Pt 3):892-902

Betts-Henderson J, Bartesaghi S, Crosier M, Lindsay S, Chen HL, Salomoni P, Gottlob I, Nicotera P. The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development. Hum Mol Genet. 2010 Jan 15;19(2):342-51.

Knapp CM, Gottlob I, McLean RJ, Rajabally YA, Abbott RJ, Rafelt S, Proudlock FA.  Vertical optokinetic nystagmus in Parkinson's diseaseMov. Disord. 2009;24:1533-8.

Sarvananthan N, Surendran M, Roberts EO, Jain S, Shah N, Proudlock FA, Thompson JR, McLean RJ, Degg C, Woodruff G, Gottlob I.  The prevalence of nystagmus:  The Leicestershire nystagmus survey. Invest. Ophthalmol. Vis. Sci. 2009.

Thomas S, Proudlock FA, Sarvananthan N, Roberts EO, Awan M, McLean RJ, Surendran M, Kumar AS, Farooq SJ, Degg C, Gale RP, Reinecke RD, Woodruff G, Langmann A, Lindner S, Jain S, Tarpey P, Raymond FL, Gottlob I.  Phenotypical characteristics of idiopathic infantile nystagmus with and without mutations in FRMD7. Brain. 2008;131:1259-67.

Farooq SJ, Gottlob I, Benskin S, Proudlock FA.  The effect of aging on torsional optokinetic nystagmus. Invest. Ophthalmol. Vis. Sci. 2008; 49:589-93.

Knapp CM, Gottlob I, McLean RJ, Proudlock FA.  Horizontal and vertical look and stare optokinetic nystagmus symmetry in healthy adult volunteers. Invest. Ophthalmol. Vis. Sci. 2008; Feb;49(2):581-8;(3.3766).

Pieh C, Simonsz-Toth B, Gottlob I.  Nystagmus characteristics in congenital stationary night blindness (CSNB). Br. J. Ophthalmol. 2008;Feb:92(2):236-40.

McLean RJ, Proudlock FA, Thomas S, Degg C, Gottlob I.  'Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin.' Ann. Neurol. 2007 Feb;61(2):130-8.

Tarpey P, Thomas S, Sarvananthan N, Mallya U, Lisgo S, Talbot CJ, Roberts EO, Awan M, Surendran M, McLean RJ, Reinecke RD, Langmann A, Lindner S, Koch M, Jain S, Woodruff G, Gale RP, Degg C, Droutsas K, Asproudis I, Zubcov AA, Pieh C, Veal CD, Machado RD, Backhouse OC, Baumber L, Constantinescu CS, Brodsky MC, Hunter DG, Hertle RW, Read RJM, Edkins S, O'Meara S, Parker A, Stevens C, Teague J, Wooster R, Futreal PA, Trembath RC, Stratton MR, Raymond FL, Gottlob I. 'Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus'Nat. Genet. 2006 Nov;38(11):1242-4.

Proudlock FA, Khanna A, Gottlob I. Filling-in along horizontal and vertical meridianInvest. Ophthalmol. Vis. Sci.  2006; 47:453-60.

Sabri K, Knapp CM, Thompson JR, Gottlob I. The VF-14 and psychological impact of amblyopia and strabismus. Invest Ophtalmol Vis Sci 2006; 47; 4386-92.



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Department of Neuroscience, Psychology and Behaviour
University of Leicester
University Road

T: +44 (0)116 252 2922