John Schwabe

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0116 229 7030

Personal details


  • BA(Hons) Biochemistry, University College, University of Oxford (1983-1987).
  • PhD Trinity Hall, University of Cambridge & MRC-Lab of Molecular Biology, Cambridge UK (1987-1991).
  • Postdoctoral fellow MRC-Lab of Molecular Biology (1992-1994).
  • Staff Scientist, Salk Institute for Biological Studies, La Jolla, California USA (1995-1997).
  • Adjunct Associate Professor, Salk Institute for Biological Studies, La Jolla, California USA (1997-1999)
  • Group Leader / Senior Scientist MRC-Lab of Molecular Biology, Cambridge UK (1997-2006)
  • Professor of Structural Biology, University of Leicester UK (2006- )
  • Head of Department of Biochemistry (2010-2015)
  • Head of Department of Molecular and Cell Biology (2015- )


John Schwabe Publications


  • Structural Biology: NMR Spectroscopy & X-ray Crystallography
  • Molecular mechanisms of the regulation of gene expression
  • Nuclear receptors and their role in metabolism, development and disease

Research summary

Link to: Professor John Schwabe's Research page

Current Research Interests

The current major interest in the group is understanding the structure and function of HDAC-containing corepressor complexes. This work is supported by a Wellcome Trust Senior Investigator Award. These complexes play an important role in the regulation of development, differentiation, cancer and homeostasis.

In addition, the group has a long-standing interest in the molecular mechanisms of transcriptional regulation by nuclear receptors. Nuclear receptors are important regulators of gene expression and are major drug targets. Our understanding of the mechanism of the ligand-regulated switch has been greatly enhanced by studies of the structure and dynamics of nuclear receptors.

In addition to these core research areas, the group is also involved in a number of collaborative projects with an emphasis on proteins and complexes implicated in various cancers.

Recent Research Funding

  • Wellcome Trust Senior Investigator Award (HDAC complexes)
  • EU Research Training Network (Nuclear receptors)
  • BBSRC Project Grant (Specificity of HDAC1 complexes)
  • Wellcome Trust Equipment Grant (Anaerobic crystallisation facility)
  • Wellcome Trust Project Grant (IDOL: The E3 ligase for the LDL receptor)
  • Wellcome Trust Programme Grant (Transcriptional Repression Complexes)

Links to:

John Schwabe Research Highlights


John Schwabe Group Members

Postdoctoral Fellows

Dr Louise Fairall

Dr Chris Millard

Dr Robert Turnbull

Dr Yun Song

PhD Students

Mr Almutasem Saleh

Mrs Irene Nigi

Ms Beatriz Romartinez

Ms Lyndsey Wright (Joint with Dr Shaun Cowley)

Ms Siyu Wang

Ms Jenni Gurnett

Experimental Officers

Ms Jacquie Greenwood

Previous Members of the Group

Ms Sian Evans

Mr Nicola Portolano

Dr Ben Goult

Dr Imran Shah

Mr Robert Paskin

Dr Thorsten Kampmann

Dr Toshimasa Itoh

Dr Guilherme Santos

Dr Jasmeen Oberoi

Mr John Gooch

Dr Mariko Ariyoshi

Dr Anna Codina

Dr Bettina Kallenberger

Dr James Love

Dr Gina Clayton

Dr Zsolt Szijgyarto

Dr Gregg Hudson

Dr Peter Watson

Dr Charles Milano

Dr Naomi Allaway

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Contact Details

Department of Molecular and Cell Biology
Henry Wellcome Building
Lancaster Road
LE1 7RH (Postal)

LE1 7HB (Sat Nav/Online maps)

T:  +44(0)116 229 7038
F:  +44(0)116 229 7123

Redfearn Lecture 2017

To Be Confirmed