Facilities and Services
Crystallography enables us to see the three-dimensional structures of biological molecules in detail. Discovering the structures of proteins and their complexes helps understand how they work. When a particular protein is involved in a disease, then knowing its structure and how it works can be used to guide the design of effective drugs. The contribution of crystallography to biological, chemical and medical sciences has been unparalleled, with 29 Nobel Prizes awarded to 48 Laureates.
The NMR Facility is superbly equipped, with four high-field instruments (including cryo-probes), for studies of macromolecular structure and interactions in solution. The Facility has an international reputation in the biological applications of NMR spectroscopy, particularly in studies of enzyme structure and mechanism and protein-ligand interactions.
The Department of Molecular and Cell Biology has excellent facilities for the characterisation of macromolecules and their biomolecular interactions. It houses an extensive array of precision instruments, top-of-the-range crystallisation robots in addition to having excellent anaerobic facilities.
Services (Core Biotechnology Services)
The Department houses a state-of-the-art fluorescence imaging facility within a dedicated suite of rooms on the 3 rd floor of the Henry Wellcome Building. The facility, primarily aimed at high resolution, multi-wavelength imaging of cultured cells, has been established through equipment grant funding generously provided by The Wellcome Trust.
The protein expression laboratory will prepare protein expression clones in the vector of your choice. Multiple expression vectors from one set of primers. All you supply are two primers and a template.
The Department makes extensive use of the Protein and Nucleic Acid Chemistry Laboratory (PNACL), which provides services for protein sequencing and automated DNA sequencing. Mass spectrometry facilities (electrospray and matrix assisted laser desorption) are available in the PNAC laboratory.
The Biomedical Joint Workshops provide an efficient, cost-effective, customer-friendly service in the design, manufacture and repair of specialist equipment required for teaching and research in the School of Medicine and the School of Biological Sciences.