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Molecular Models of Diseases Kinetics

It is generally acknowledged that transmittable spongiform encephaloathies diseases (TSE), such as scrapie, kuru and kind of Creutzfeld-Jacob disease are related to formation of misfolded fibril-like prion proteins.  Using a molecular model of the aggregation kinetics we describe the kinetics of the prion growth and derived the size distribution of the fibril aggregates.

 My main  publications on the topic are:

 T.Poeschel, N.V. Brilliantov, and C. Frommel,
 Kinetics of Prion Growth,
 Biophysical Journal, 85, (2003) 3460-3474. 
 

Brownian Motion of Biomolecules

Biological functions of biomolecules in nature are intrinsically related to their mobility, i.e. to
the properties of the Brownian motion of these particles. Usually they are strongly  charged or have a large electrical dipolar moment.  The intensive electrostatic interactions between the charged and/or dipolar biomolecules or between the macromolecules and the polar solvent influence significantly their Brownian Motion .

My main  publications on the topic are:

N.V.Brilliantov, N.G.Vostrikova, V.P.Denisov, Yu.M.Petrusievich and O.P.Revokatov
Influence of dielectric friction and near-surface  increase  of viscosity  on  rotational
Brownian  motion  of  charged  biopolymers in solution,
Biophysical Chemistry, 46 (1993)  227-236.

Yu. M. Petrusevitch and N. V. Brilliantov,
Dielectric properties of protein solutions and interactionof electromagnetic fields with biosystems.
Bull. Mosc. State Univ.,  Ser.3, N4 (1994) 63-67 (in russian).

N.V.Brilliantov, A.I.Kviatkievich, Yu.M.Petrusievich and O.P. Revokatov,
Influence  of  macromolecules  dipolar  moment  on  the frequency dependence of
the NMR-relaxation  coefficients of  biopolymers  in  solution.
Radiospektroskopiya, Perm, 1988,150-154 (in russian).

N.V.Brilliantov, A.I.Kviatkievich, Yu.M.Petrusievich and O.P.Revokatov,
Rotational Brownian motion of  polar  macromolecules  in solutions,
Dokl.  Akad. Sci.  USSR,  304,  N2  (1989) 340-345   (in russian).
 

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