Professor Wilhelm Schwaeble

Professor of Immunology and Royal Society-Wolfson Research Merit Award Holder

Contact details

Lab: 231, MSB/Office: 232, MSB

Telephone: (+44) (0)116 252 5674

E-mail: ws5@le.ac.uk 

Research

Research focuses on four main aspects;

  • Molecular mechanisms involved in the induction and maintenance of inflammation and neurodegeneration in the central nervous system.
  • Characterisation of a novel pathway of the innate anti-microbial immune response, the lectin pathway of complement activation.
  • Development of therapeutic approaches to treat inflammatory disease and limit tissue injury.
  • Analysis of human gene polymorphisms leading to predispositions for infectious disease.
  • Further research interests
  • Publications

Selected Recent Publications

Zhou H-F, Yan H, Stover CM, Fernandez TM, Rodriguez de Cordoba S, Song W-C, Wu X, Tompson RW,  Schwaeble WJ, Atkinson JP, Hourcade DE, Pham TN. Antibody directs properdin-dependent complement alternative pathway activation in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci USA 2012;109:415-22

Ali YM, Lynch NJ, Haleem KS, Kadioglu A, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLOS Pathog 2012;8:e1002793

Dimitrova P, Ivanovska N, Belenska L, Milanova V, Schwaeble WJ, Stover CM. Abrogated RANKL expression in properdin-deficient mice is associated with better outcome of collagen-antibody-induced arthritis. Arthritis Res Ther 2012;14:R173

Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, Matsuzaka T, Kanno K, Liu Y, Tsuchiya K, Kawamura I, Ikawa M, Waguri S, Wada I, Matsushita M, Schwaeble WJ, Fujita T. Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to streptococcus pneumoniae infection. J Immunol 2012;189:5860-6

Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook T, Song W, Stover CM, Pickering MC. Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol 2013;24(1):43-52

Kenawy H, Ali YM, Lynch NJ, Rajakumar K, Kadioglu A, Stover CM, Schwaeble WJ. A total absence of the lectin activation pathway of complement does not predispose to increased susceptibility to Pseudomonas aeruginosa infections. Immunobiol 2012;217:272-80.

Schwaeble WJ, Lynch NJ, Clark N, Marber M, Samani NJ, Mohammed Ali Y, Dudler T, Parent B, Lhotta K, Wallis F, Farrar A, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of MASP2 confers a significant degree of protection from myocardial and gastro-intestinal ischemia/reperfusion injury. Proc Natl Acad Sci 2011;108:7523-28

Fuchs A, Pinto AK, Schwaeble WJ, Diamond MS. The lectin pathway of complement activation contributes to protection from West Nile virus infection. Virology 2011;412:101-9

Fuchs A, Lin TY, Beasley DW, Stover CM, Schwaeble WJ, Pierson TC, Diamond MS. Direct complement restriction of Flavivirus infection requires glycan recognition by mannose binding lectin. Cell Host Microb 2010;8:186-95

Schwaeble W, Constantinescu S.  Relationship between cannabinoids and the immune system. Special issue 8: 2010 Introduction. Immunobiology 2010;215:587

Lopez NC, Valck C, Ramirez G, Rodriguez M, Ribeiro C, Orellana J, Maldonado I, Albini A, Anacona D, Lemus D, Aguilar L, Schwaeble WJ, Ferreira A. Antiangiogenic and antitumor effects of Trypanosoma cruzi calreticulin. PLoS Negl Trop Dis 2010;4:e730

Dimitrova P, Ivanovska N, Schwaeble W, Gyurkovska V, Stover C. The role of properdin in murine zymosan-induced arthritis. Mol Immunol 2010;47:1458-66

Valck C, Ramirez G, Lopez N, Ribeiro CH, Maldonado I, Sanchez G, Ferreira VP, Schwaeble W, Ferreira A. Molecular mechanisms involved in the inactivation of the first component of human complement of Trypanosoma cruzi calreticulin. Mol Immunol 2010;47:1516-21

Venkatraman Girija U, Furze C, Toth J, Schwaeble WJ, Mitchell DA, Keeble AH, Wallis R.  Engineering novel complement activity into a pulmonary surfactant protein. J Biol Chem 2010;285:10546-52

Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K. Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot. Immunology 2010;129:482-95

Wallis R, Mitchell DA, Schmid R, Schwaeble WJ, Keeble AH. Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology 2010;215:1-11

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Contact Details

Department of Infection, Immunity and Inflammation,
Maurice Shock Medical Sciences Building,
University Road,
Leicester, LE1 9HN, UK 

General enquiries to:
Alison Brown

T:+44 (0)116 252 2951
F:+44 (0)116 252 5030

Postgraduate enquiries to: 
Susan Kapadia (PhD)

Anna Boyce (MSc)

Erasmus and Study Abroad Co-ordinator:

Professor Peter Andrew

T: +44 (0)116 252 2951

Other contact details can be found in People

Head of Department: Professor Peter Andrew