Publications for last 10 years only
Kouser L, Abdul-Aziz M, Nayak A, Stover CM, Sim RB, Kishore U. Properdin and factor HL opposing players on the alternative complement pathway "see-saw". Front Immunol 2013;4:93
Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook T, Song W, Stover CM, Pickering MC. Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency. J Am Soc Nephrol 2013;24(1):43-52
Dimitrova P, Ivanovska N, Belenska L, Milanova V, Schwaeble WJ, Stover CM. Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis. Arthritis Res Ther 2012;14(4):R173
Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate murine response to pneumococcal infection. PLoS Pathog 2012;8(7):e1002793
Gavreau D, Roy C, Tom FQ, Lu H, Miegueu P, Richard D, Song WC, Stover C, Cianflone K. A new effector of lipid metabolism: complement factor properdin. Mol Immunol 2012;51(1):73-81
Zhou HF, Yan H, Stover CM, Fernandez TM, Rodriguez de Cordoba S, Song WC, Wu X, Thompson RW, Schwaeble WJ, Atkinson JP, Hourcade DE, Pham CT. Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Proc Natl Acad Sci USA 2012;109(7):E415-22
Francescut L, Steiner T, Byrne S, Cianflone K, Francis S, Stover C. The role of complement in the development and manifestation of murine atherogenic inflammationL novel avenues. J Innate Immun 2012;4(3):260-72
Kenawy HI, Ali YM, Rajakumar K, Lynch NJ, Kadioglu A, Stover CM, Schwaeble WJ. Absence of the lectin activation pathway of complement does not increase susceptibility to Pseudomonas aeruginosa infections. Immunobiology 2012;217(2):272-80
Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Sci USA 2011;108(18):7523-8
Stover C. Dual role of complement in tumour growth and metastasis [Review]. Int J Mol Med 2010;25(3):307-13
Staley KG, Kuehni CE, Strippoli MP, McNally T, Silverman M, Stover C. Properdin in childhood and its association with wheezing and atopy. Pediatr Allergy Immunol 2010;21(4 pt 2):e787-91
Dimitrova P, Ivanovska N, Schwaeble C, Gyurkovska V, Stover C. The role of properdin in murine zymosan-induced arthritis. Mol Immunol 2010;47(7-8):1458-66
Pattrick M, Luckett J, Yue L, Stover C. Dual role of complement in adipose tissue. This work advances understanding on the role of adipose tissue-derived complement proteins and products in vascular inflammation.Mol Immunol 2009;46(5):755-60.
Stover C, Luckett J, Echtenacher B, Figgitt S, Dupont A, Brown J, Maennel D, Schwaeble W. Properdin plays a protective role in polymicrobial septic peritonitis. J Immunol 2008;180(5):3313-8. See a detailed description of this phenotype allele.
(and) Ivanovska N, Dimitrova P, Luckett J, El-Rachkidy Lonnen R, Schwaeble W, Stover C. Properdin deficiency in murine models of nonseptic shock. J Immunol 2008;180:6962-6269. These two papers describe, for the first time, a properdin-deficient mouse line generated at the University of Leicester and its phenotype in different models of inflammation.
Salehen N, Stover C. The role of complement in the success of vaccination with conjugated vs unconjugated polysaccharide antigen. Review. Vaccine 2008;26(4):451-9. This review analyses the contribution of complement in response to polysaccharide vaccines with emphasis on splenic microarchitecture.
Unterberger C, Hanson S, Klingenhoff A, Oesterle D, Frankenberger M, Endo Y, Matsushita M, Fujita T, Schwaeble W, Weiss EH, Ziegler-Heitbrock L, Stover C. Stat3 is involved in control of MASP2 gene expression. Biochem Biophys Res Commun 2007;364:1022-1025. This paper identifies a transcription factor involved in regulating expression of the effector component of lectin pathway activation. It is directly relevant to the in vivo models conducted using the MASP2 deficient mouse line (reperfusion/injury).
Staley K, Stover C, Strippoli MP, Spycher B, Silverman M, Kuehni C. Mannan-binding lectin in young children with asthma differs by level of severity. J Allergy Clin Immunol 2007;119:503-505.
Stover C, Barrett S, Lynch NJ, Barker JN, Burden D, Trembath R, Schwaeble W, Veal C. Functional MASP2 single nucleotide polymorphism plays no role in psoriasis. Br J Dermatol 2005;152(6):1313-5
Lynch NJ, Khan SU, Stover CM, Sandrini SM, Marston D, Presanis JS, Schwaeble WJ. Composition of the lectin pathway of complement in Ghallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds. J Immunol 2005;174(8):4998-5006
Schwaeble W, Stover C. Disruption of the murine gene for the mannan binding lectin associated serine protease-2 (MASP-2) provides the key model to study experimental lectin pathway deficiency (XXth International Complement Workshop, Honolulu, Hawaii, June 13-18, 2004)
Stover CM, Lynch NJ, Hanson SJ, Windbichler M, Gregory SG, Schwaeble WJ. Organization of the MASP2 locus and its expression profile in mouse and rat. Mamm Genome 2004;15(11):887-900
Stover CM, Lynch NJ, Dahl MR, Hanson S, Takahashi M, Frankenberger M, Ziegler-Heitbrock L, Eperon I, Thiel S, Schwaeble WJ. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene. Genes Immun 2003;4(5):374-84