Dr Alan Bevington
Lecturer
Contact details
Office: 117/119, Renal Laboratory, MSB
Telephone: (+44) (0)116 223 1402
E-mail: ab74@le.ac.uk
Research Interests
- The metabolic basis of the catabolic state that occurs in patients with chronic renal failure, in particular the stimulation of protein catabolism and the impairment of protein synthesis that occurs in skeletal muscle cells in response to uraemic metabolic acidosis.
- The mechanism whereby low extracellular pH transduces signals into cultured skeletal muscle cells and the involvement of free amino acids and amino acid transport proteins in these signals.
- The role of the SNAT2 amino acid transporter in the regulation of amino acid signalling, insulin sensitivity and protein metabolism in mammalian cells.
- Publications
Selected Recent Publications
Watson EL, Kosmadakis GC, Smith AC, Viana JL, Brown JR, Molyneux K, Pawluczyk IZA, Mulheran M, Bishops NC, Shirreffs S, Maughan RJ, Owen PJ, John SG, McIntyre CW, Feehally J, Bevington A. Combined walking exercise and alkali therapy in patients with CKD4-5 regulates intramuscular free amino acid pools and ubiquitin E3 ligase expression. Eur J Appl Physiol 2013 (in press). Doi: 10.1007/s00421-013-2628-5
Kosmadakis GC, Bevington A, Smith AC, Clapp EL, Viana JL, Bishop NC, Feehally J. Physical exercise in patients with severe kidney disease. Nephron Clin Pract 2010;115(1):c7-c16
