Professor Chris Brightling
Wellcome Senior Research Fellow and Clinical Professor in Respiratory Medicine
Contact details
Secretary: Mrs Jean MacDonald
Office: CS090, Respiratory Medicine, Glenfield Hospital
Telephone: (+44) (0)116 256 3998
E-mail: ceb17@le.ac.uk / jm454@le.ac.uk
Research
Immunopathogenesis of airway disease namely asthma, chronic obstructive pulmonary disease (COPD) and chronic cough;
Current projects include understanding the interactions between mast cells and airway smooth muscle cells in the development of the asthmatic phenotype, airway smooth muscle migration and remodelling in asthma and COPD.
Selected Recent Publications
Bafadhel M, McKenna S, Agbetile J, Fairs A, Desai D, Mistry V, Morley JP, Pancholi M, Pavord ID, Wardlaw AJ, Pashley CE, Brightling CE. Aspergillus fumigatus during stable state and exacerbations of COPD. Eur Respir J 2013;Apr 18 [epub ahead of print]
Kuipers I, Louis R, Manise M, Dentener MA, Irvin CG, Janssen-Heininger YM, Brightling CE, Wouters EF, Reynaert NL. Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics. Eur Respir J 2013;41(2):469-72
Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, May R, Sleeman MA, Anderson IK, Brightling CE. Expression of the TH17-associated cytokines interleukin (IL)17A and F in asthma and chronic obstructive pulmonary disease. Chest 2010;238(5):1140-7
Mutalithas K Guillen C, Day C, Brightling CE, Pavord ID, Wardlaw AJ. CRTH2 expression on T cells in asthma. Clin Exp Immunol 2010;161(1):34-40
Mutalithas K, Guillen C, Raport C, Kolbeck R, Soler D, Brightling CE, Pavord ID, Wardlaw AJ. Expression of CCR8 is increased in asthma. Clin Exp Allergy 2010;40(8):1175-85
Singapuri A, McKenna S, Brightling CE, Bradding P. Manitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness. Respirology 2010;15(3):510-15
Desai D, Brightling CE. Cough due to asthma, cough-variant asthma and non-asthmatic eosinophilic bronchitis. Otolaryngol Clin North Am 2010;43(1):123-30
Siddiqui S, Mistry V, Doe C, Stinson S, Foster M, Brightling C. Airway wall expression of OX40/OX40L and interleukin-4 in asthma. Chest 2010;137(4):797-804
Kaur D, Hollins F, Saunders R, Woodman L, Sutcliffe A, Cruse G, Bradding P, Brightling C. Airway smooth muscle proliferation and survival is not modulated by mast cells. Clin Exp Allergy 2010;40(2):279-88
Brightling CE, Saha S, Hollins F. Interleukin-13: prospects for new treatments. Clin Exp Allergy 2010;40(1):42-9
