Head of Department and Professor of Microbial Pathogenesis

Personal Assistant: Mrs Sheila Hewitt

Lab: 229, MSB/Office: 229a, MSB

Telephone: (+44) (0)116 252 2951

E-mail: sam20@le.ac.uk

Research

• Host and bacterial responses during pneumonia, meningitis and COPD and during pathogen interactions with the external environment. The pathogens being studied are Streptococcus pneumoniae, Mycobacterium tuberculosis and Listeria monocytogenes.
• Development of new vaccines and drug treatments of pneumonia and meniningitis.
• The genetic basis of susceptibility to infectious diseases.
• Interaction of bacteria with epithelia, mucus and abiotic surfaces.
• Professor Andrew has coordinated three EU-funded projects, one of which (PNEUMOPATH) is still extant. Click on the links for more information about the projects.
  PNEUMOPATH,  LMTOOCHE
• Publications

Selected Recent Publications

Cruse G, Fernandes VE, de Salort J, Pankhania D, Marinas MS, Brewin H, Andrew PW, Bradding P, Kadioglu A. Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol 2010;184(12):7108-15

Fadaee-Shohada M, Hirst RA, Rutman A, Roberts IS, O'Callaghan C, Andrew PW. The behaviour of both listeria monocytogenes and rat ciliated ependymal cells is altered during their co-culture. PLoS One 2010;5(5):e10450

Heaselgrave W, Andrew PW, Kilvington S. Acidified nitrite enhances hydrogen peroxide disinfection of Ananthamoeba, bacteria and fungi. J Antimicrob Chemother 2010;65(6):1207-14

Richards L, Ferreira DM, Miyaji EN, Andrew PW, Kadioglu A. The immunising effect of pneumococcal nasopharyngeal colonisation: protection against future colonisation and fatal invasive disease.  Immunobiology 2010;215(4):251-63

Terra VS, Homer KA, Rao SG, Andrew PW, Yesilkaya H. Characterization of novel beta-galactodisase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae. Infect Immun 2010;78(1):348-57