Martin Tobin
Professor of Genetic Epidemiology and Public Health
CONTACT DETAILS
Department of Health Sciences
University of Leicester
Adrian Building, University Road
Leicester, LE1 7RH
Tel: 00 44 116 229 7270
Email: mt47@le.ac.uk
POSTGRADUATE OPPORTUNITIES
If you are a high-achieving post-doctoral scientist in an area relevant to our expertise, we would be interested to hear from you. Please direct enquiries to either Louise Wain (louisewain@le.ac.uk) or Martin Tobin (mt47@le.ac.uk).
Go To:
Postgraduate Supervision and Teaching
RESEARCH INTERESTS
- Investigation of the genetic determinants of common complex diseases and traits, including:
- genome-wide studies of common and rare sequence variation
- influence of copy number variation
- lung function and respiratory disease
- cardiovascular disease and traits, particularly blood pressure
- public health impact of genetic epidemiology studies
- Development and utilisation of new methods for the above studies.
Link to "Video: Martin Tobin explains his research into the genetics of lung health and lung disease"
http://www.youtube.com/watch?v=Pc8oWAzi1FI
Link to "Royal Society Summer Science Exhibition 2012 - Breathless Genes: The lung and the short of it"
http://sse.royalsociety.org/2012/exhibits
RESEARCH PROJECTS
Hall IP, Tobin MD (co-PIs), Wain LV, Strachan D. UK Biobank Lung Exome Variant Evaluation (UK BiLEVE) consortium. (MRC) Nov 2012-Nov 2014
MRC Senior Clinical Fellowship. A program of research in respiratory and cardiovascular genetic epidemiology. Tobin MD (MRC), 1st Jan 2011-31 Dec 2015.
Hall IP, Sayers I, Tobin MD. Defining the genetic contribution and functional role to altered lung function of genes identified by GWAS meta-analysis (MRC), May 2011-May 2016.
Soler Artigas M, Wain LV, Tobin MD. Genetic variants predisposing to lung ageing and chronic obstructive pulmonary disease (Medisearch), 1st May 2010 – 30th April 2013.
Tobin MD, Hall IP. Determinants of lung function and chronic obstructive pulmonary disease. Collaborative Research and Development funding [EU/EMDA], July 2010 – March 2011 (PI).
Brightling et al (34 partners) AirPROM (EU)
PROFESSIONAL ACTIVITIES
Honorary Consultant in Public Health
Academic Trainer in Public Health, East Midlands School of Public Health
POSTGRADUATE SUPERVISION AND TEACHING
Research Students
- Tom Palmer Oct 2005 – Oct 2008, PhD awarded, Methods for Mendelian Randomization studies (MRC Capacity Building Studentship). Destination: Lecturer, University of Warwick.
- Nick Masca Jan 2008 – 2011, PhD awarded, Application and development of approaches to combine information in epidemiological studies (British Heart Foundation Studentship). Destination: Research associate, University of Leicester
- Amadou Gaye Jan 2009 – Jan 2013, PhD awarded, Statistical power in large scale genetic association studies (MRC Capacity Building Studentship). Destination: Research associate, University of Leicester
- Maria Soler Artigas 2010 - present (part-time), Genetic Epidemiology of Lung Function and COPD.
- Vicki Jackson from Oct 2012. Rare genetic variants associated with lung function and lung disease (COPD).
Please contact mt47@leicester.ac.uk for details of PhD opportunities.
SELECTED PUBLICATIONS
Years: 2005-6, 2007, 2008, 2009, 2010, 2011, 2012, 2013
2013
Codd V, Nelson CP, …(many authors)…Tobin MD… Jarvelin MR, Slagboom PE, Thompson JR, Spector TD, van der Harst P, Samani NJ. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet.2013 Apr;45(4):422-7. PubMed PMID: 23535734.
Kerr SM, Campbell A, Murphy L, Hayward C, Jackson C, Wain LV, Tobin MD,Dominiczak A, Morris A, Smith BH, Porteous DJ. Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study. BMC Med Genet. 2013 Mar 22;14(1):38. PubMed PMID: 23521772.
Tobin MD. Body mass index, asthma, and genetic variation. Clin Exp Allergy.2013 Apr;43(4):383-4. PubMed PMID: 23517033.
2012
Hancock DB*, Soler Artigas M*,…Cassano PA†, Strachan DP†, Fornage M†, Hall IP†, Dupuis J†, Tobin MD†, and London SJ†. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genetics 2012, 8(12): e1003098. († jointly directed the work).
Wilk JB*, …Probst-Hensch N*, Gharib SA*, Hall IP*, O'Connor GT*, Tobin MD*, Stricker BH*. Genome Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction. Am J Respir Crit Care Med. 2012 Jul 26. (*equal contribution)
Wain LV, Artigas MS, Tobin MD. What can genetics tell us about the cause of fixed airflow obstruction. Clin Exp Allergy. 2012 Aug;42(8):1176-82. PubMed PMID: 22805464.
Wan YI, Shrine NR, Soler Artigas M, Wain LV, … Ferreira MA, Thompson PJ, Tobin MD, Sayers I, Hall IP. Genome-wide association study to identify genetic determinants of severe asthma. Thorax. 2012 Sep; 67(9): 762-8. PubMed PMID: 22561531.
Gaunt TR, Shah S, Nelson CP… Tobin MD, Humphries SE, Talmud PJ, Macfarlane PW, Hingorani AD, Samani NJ, Kumari M, Day IN. Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip. Circ Cardiovasc Genet. 2012 Dec;5(6):630-8. PubMed PMID: 23139254.
Koskela J, Kähönen M, Nieminen T, Lehtinen R, Viik J, Nikus K, Niemelä K,Kööbi T, Tobin MD, Samani NJ, Turjanmaa V, Pörsti I, Lehtimäki T. Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.Scand J Clin Lab Invest. 2012 Apr;72(2):100-7. Epub 2011 Dec 1. PubMed PMID:
22133205.
2011
Soler Artigas M*, Loth DW*, Wain LV* et al. Genome-wide association and large scale follow-up identifies 16 novel loci for lung function. Nature Genetics, 2011 25th Sept [Epub ahead of print].PMID 21909110
Wain LV et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. 2011 Sep 11 [Epub ahead of print] PubMed PMID: 21909110
Ehret GB et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11. [Epub ahead of print] PubMed PMID: 21909115.
Soler Artigas M, Wain LV, Tobin MD. Genome-wide association studies in lung disease. Thorax. 2011 Aug 19. [Epub ahead of print] PubMed PMID: 21856699.
Soler Artigas M et al. Effect of 5 Genetic Variants Associated with Lung Function on the Risk of COPD, and their Joint Effects on Lung Function. Am J Respir Crit Care Med. 2011 Jun 16. [Epub ahead of print] PubMed PMID: 21680943.
Obeidat M et al. A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS One. 2011;6(5):e19382. Epub 2011 May 20. PubMed PMID: 21625484.
Silverman EK et al. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD.2011 Apr;8(2):121-35. PubMed PMID: 21495840.
Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Doering A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ. Dense Genotyping of Candidate Gene Loci Identifies Variants Associated with High-Density Lipoprotein Cholesterol. Circ Cardiovasc Genet. 2011 Feb 8. [Epub ahead of print] PubMed PMID: 21303902.
Edmondson AC, Braund PS, Stylianou IM, Khera AV, Nelson CP, Wolfe ML, Derohannessian SL, Keating BJ, Qu L, He J, Tobin MD, Tomaszewski M, Baumert J, Klopp N, Doering A, Thorand B, Li M, Reilly MP, Koenig W, Samani NJ, Rader DJ. Dense Genotyping of Candidate Gene Loci Identifies Variants Associated with High-Density Lipoprotein Cholesterol. Circ Cardiovasc Genet. 2011 Feb 8. [Epub ahead of print] PubMed PMID: 21303902.
Kaess BM, Tomaszewski M, Braund PS, Stark K, Rafelt S, Fischer M, Hardwick R, Nelson CP, Debiec R, Huber F, Kremer W, Kalbitzer HR, Rose LM, Chasman DI, Hopewell J, Clarke R, Burton PR, Tobin MD, Hengstenberg C, Samani NJ. Large-scale candidate gene analysis of HDL particle features. PLoS One. 2011 Jan 21;6(1):e14529. PubMed PMID: 21283740; PubMed Central PMCID: PMC3024972.
Reinhard W, Kaess BM, Debiec R, Nelson CP, Stark K, Tobin MD, Macfarlane PW, Tomaszewski M, Samani NJ, Hengstenberg C. Heritability of Early Repolarization - A Population-Based Study. Circ Cardiovasc Genet. 2011 Jan 31. [Epub ahead of print] PubMed PMID: 21282333.
Wain LV, Tobin MD. Copy number variation. Methods Mol Biol. 2011;713:167-83. PubMed PMID: 21153619
Masca N, Sheehan NA, Tobin MD. Pharmacogenetic interactions and their potential effects on genetic analyses of blood pressure. Stat Med. 2011 Mar 30;30(7):769-83
2010
Repapi E†, Sayers I†, Wain LV†, …Elliott P†, Strachan DP†, Hall IP†, Tobin MD†. Genome-wide association study identifies five new loci associated with lung function. Nature Genetics 2010 Jan;42(1):36-44. Epub 2009 Dec 13. [† contributed equally]
Codd V, … Tobin MD, Hall AS, Thompson JR, Spector T, Samani NJ. Common variants near TERC are associated with mean telomere length. Nature Genetics 2010 Mar;42(3):197-9
Wellcome Trust Case Control Consortium. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010 Apr 1;464(7289):713-20.
Blauw HM…Tobin MD, Wain LV…van den Berg LH. A large genome scan for rare CNVs in amyotrophic lateral sclerosis. Hum Mol Genet. 2010 Aug 10. [Epub ahead of print].
Wolfson M, Wallace SE, Masca N, Rowe G, Sheehan NA, Ferretti V, Laflamme P, Tobin MD, Macleod J, Little J, Fortier I, Knoppers BM, Burton PR. DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled analysis of individual-level data without sharing the data. Int J Epidemiol. 2010 Jul 14. [Epub ahead of print]
Moffat M et al for the GABRIEL consortium. A Large-Scale, Consortium-Based Genomewide Association Study of Asthma. N Engl J Med 2010; 363:1211-1221.
Tomaszewski M, Debiec R, Braund PS, Nelson CP, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton PR, Mooser V, Charchar FJ, Thompson JR, Tobin MD, Samani NJ. Genetic Architecture of Ambulatory Blood Pressure in the General Population: Insights From Cardiovascular Gene-Centric Array. Hypertension. 2010 Dec;56(6):1069-1076. Epub 2010 Nov 8.
2009
Wain LV, Pedroso I, Landers JE, Breen G, Shaw CE, Leigh PN, Brown RH, Tobin MD†, Al-Chalabi A†. The Role of Copy Number Variation in Susceptibility to Amyotrophic Lateral Sclerosis: Genome-wide Association Study and Comparison with Published Loci. PLoS One. 2009 Dec 4;4(12):e8175 [† contributed equally].
Wain LV, Armour JAL, Tobin MD. Genomic copy number variation, human health, and disease. Lancet 2009, online first, June 16.
Newton-Cheh C*, Johnson T*, Gateva V*, Tobin MD* et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 2009, published online May 10th. [* joint first authors]
Jackson C, Dixon-Woods M, Tobin M, Young B, Heney D, Pritchard-Jones K. Seeking consent to tissue banking: a survey of health professionals in childhood cancer. European Journal of Cancer Care 2009; 18:391-400.
Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P, Savelieva I, Zheng D, Dalageorgou C, Farrall M, Samani NJ, Connell J, Brown M, Dominiczak A, Lathrop M, Zeggini E, Wain LV; Wellcome Trust Case Control Consortium; DCCT/EDIC Research Group, Newton-Cheh C, Eijgelsheim M, Rice K, de Bakker PI; QTGEN consortium, Pfeufer A, Sanna S, Arking DE; QTSCD consortium, Asselbergs FW, Spector TD, Carter ND, Jeffery S, Tobin M, Caulfield M, Snieder H,Paterson AD, Munroe PB, Jamshidi Y. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One. 2009 Jul 9;4(7):e6138.
2008
Tobin MD, Timpson NJ, Wain LV, Ring S, Jones LR, Emmett PE, Palmer TM, Ness AR, Samani NJ, Davey Smith G, Burton PR. Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children. Hypertension 2008 Nov; 52(5):974-979.
Sheehan NA, Didelez V, Burton PR, Tobin MD. Mendelian Randomisation and Causal Inference in Observational Epidemiology. PLoS Medicine 2008 Aug; 5(8):1205-1210.
Palmer TM, Thompson JR, Tobin MD. Meta-analysis of Mendelian randomization studies incorporating all three genotypes. Statistics in Medicine 2008 Sept; 27(30):6570-6582.
Samani NJ*, Braund PS*, Erdmann J*, Götz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M, Hengstenberg C, Stark K, Ziegler A, Caulfield M, Burton PR, Schunkert H, Tobin MD. The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. Journal of Molecular Medicine 2008 Nov; 86(11):1233-1241.
Samani NJ, Raitakari OT, Sipilä K, Tobin MD, Schunkert H, Juonala M, Braund PS, Erdmann J, Viikari J, Moilanen L, Taittonen L, Jula A, Jokinen E, Laitinen T, Hutri-Kähönen N, Nieminen MS, Kesäniemi YA, Hall AS, Hulkkonen J, Kähönen M, Lehtimäki T. Coronary Artery Disease-Associated Locus on Chromosome 9p21 and Early Markers of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2008 Sept; 28(9):1679-1683.
Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ. Common Variants in Genes Underlying Monogenic Hypertension and Hypotension and Blood Pressure in the General Population. Hypertension 2008 Jun; 51(6): 1658-64.
Tobin MD, Kähönen M, Braund P, Nieminen T, Hajat C, Tomaszewski M, Viik J, Lehtinen R, Ng G.A., Macfarlane P.W., Burton PR, Lehtimäki T, Samani NJ. Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations. International Journal of Epidemiology 2008 Oct; 37(5):1132-1141.
Palmer TM, Thompson JR, Tobin MD, Sheehan NA, Burton PR. Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses. International Journal of Epidemiology (Advance Access) Oct; 37(5):1161-1168.
Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ, Marçano AC, Hajat C, Burton P, Deloukas P, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Spector T, Samani NJ, Caulfield MJ, Munroe PB. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet. 2008 Jan;82(1):139-49.
2007
The Wellcome Trust Case Control Consortium. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 2007 Nov;39(11):1329-1337.
The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447: 661-678.
Tobin MD, Sheehan NA, Samani NJ, Burton PR. The Genetic Epidemiology of Hypertension. Chapter in Handbook of Hypertension, Volume on Genetics of Hypertension. Elsevier, Amsterdam, 2007
Burton PR, Bowden J, Tobin MD. Epidemiology and Genetic Epidemiology. Chapter in Balding DJ, Bishop M, Cannings C, Handbook of Statistical Genetics, 3rd Ed. Wiley, Chichester, 2007
Dixon-Woods M, Ashcroft R, Clare J. Jackson, Tobin MD, Kivits J, Burton PR, Samani. Beyond ‘‘misunderstanding’’: Written information and decisions about taking part in a genetic epidemiology study. Social Science and Medicine (in press, 2007).
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, Konig IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007 Aug 2;357(5):443-53.
Ruse CE, Hill MC, Tobin M, Neale N, Connolly MJ, Parker SG, Wardlaw AJ. Tumour necrosis factor gene complex polymorphisms in chronic obstructive pulmonary disease. Respir Med. 2007 Feb;101(2):340-4.
Maznyczka A, Mangino M, Whittaker A, Braund P, Palmer T, Tobin M, Goodall AH, Bradding P, Samani NJ. Leukotriene B(4) production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction. Clin Sci (Lond). 2007 Jun;112(7):411-6.
2005/6
Cosford PA, O'Mahony M, Angell E, Bickler G, Crawshaw S, Glencross J, Horsley SS, McCloskey B, Puleston R, Seare N, Tobin MD. Public health professionals' perceptions toward provision of health protection in England: a survey of expectations of Primary Care Trusts and Health Protection Units in the delivery of health protection. BMC Public Health; 2006 Dec 7;6:297.
Burton PR*, Tobin MD*, Hopper J. Key concepts in Genetic Epidemiology. Lancet 2005; 366(9489): 941-951. [* joint first authors]
Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation 2005; 112: 3423-3429
Tobin MD, Sheehan NA, Scurrah KJ, Burton PR. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Statistics in Medicine 2005; 24(19): 2911-2935.
Seale C, Kirk D, Tobin M, Burton P, Grundy R, Pritchard-Jones K, Dixon-Woods M. Mass media portrayals of removal of children’s tissue and impact on a tumour bank: a qualitative and quantitative analysis. BMJ 2005; 331(7513); 401-3.
Burton PR, Scurrah KJ, Tobin MD, Palmer LJ. Covariance components models for longitudinal family data. International Journal of Epidemiology 2005; 34(5): 1063-77.
Thompson JR, Minelli C, Abrams KR, Tobin MD, Riley R. Meta-analysis of genetic studies using Mendelian randomisation: a multivariate approach. Statistics in Medicine 2005; 24(14): 2241-2254.
