Personal tools

Alex Sutton

Professor of Medical Statistics

CONTACT DETAILS

Department of Health Sciences
University of Leicester
Adrian Building, University Road
Leicester, LE1 7RH
 
Tel: 00 44 116 229 7268
Email: ajs22@le.ac.uk   

 

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Research Interests

Research Projects

Professional Activities

Postgraduate Supervision and Teaching

Selected Publications

 

RESEARCH INTERESTS:

My research interests include:

  • Meta-analysis and systematic review methods
  • Publication bias
  • Bayesian methods
  • Multi-parameter evidence synthesis
  • Statistical methods in health economics.

 

RESEARCH PROJECTS

Current projects include:

Use of Bayesian methods to inform Health Technology Assessment Decision-Making.
£360,000 MRC
Sutton AJ (PI), Abrams KR, Cooper NJ, Spiegelhalter, D.
Duration: 24 months – start September 2008.

Keeping children safe at home: a multicentre collaborative research programme to reduce childhood injuries 
£1998,442 NHS National Institute for Health Research (NIHR)
D Kendrick,  AJ Sutton, NJ Cooper, Towner E, Reading R, McColl E, Watson M, Coupland C, Illingworth R, Brady B, Coffey F, Hayes M
5 years starting 1 April 2009

Investigation of discrepancies between direct and indirect comparison of competing healthcare interventions (G0701607)
£300,000. MRC
Song F, Sutton AJ, Glenny AM, Deeks J, Loke Y, Parekh S.
Duration: 24 Months – start April 2008

Management strategies for sciatica
£258,243 NHS Executive Research and Development Health Technology Assessment Programme
Williams, N. Lewis, R., Phillips, C., Sutton, A.J., Burton, K., Fitzsimmons, Hendry, M., Belcher, J., Rickard, I.
Duration: 18 months – start January 2008

PhD Statistical Issues in Cost-Effectiveness analysis.
MRC Capacity Building PhD Studentship.
Manca, A & Sutton, AJ 
Duration 3 years.  - start October 2008

National Institute for Health and Clinical Excellence Decision Support Unit (NDSU)
£600,000 
Department of Health
Abrams, K.R., Akehurst, R., Brazier, J., Brennan, A., Chilcott, J., Claxton, K., Cooper, N., McCabe, C., O’Hagan, A., Paisley, S., Palmer, S., Sculpher, M., Sutton, A.J.,
Duration 9 years – Start March 2003

Publication bias in medical decision modelling
£53,200 MRC HSRC PhD Studentship
Principal supervisor: Sutton, A.J., co-supervisors: Ades, A.E., Sterne, J., Cooper, N.J., Abrams, K.R..
Duration 4 years – start October 2005

The cost-effectiveness of investigation and hospital admission for minor (GCS 13-15) head injury.
£176,059. NHS Executive Research and Development Health Technology Assessment Programme
Goodacre S, Sutton AJ, Lecky F, Coats T, Pigott T, Sampson F, Stevenson, M.
Duration 14 Months

Anti-obesity drugs in primary care.
Approx: £220,000 NHS Executive Research and Development Health Technology Assessment Programme
Ara R, Sutton AJ, Cooper NJ, Abrams KR, Brazier J, Booth A, Khunti K, Gillett M, Rees A.
Duration 12 months - September 2008.

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PROFESSIONAL ACTIVITIES

Recent invited presentations include:

International

October 2008, Cochrane Colloquium, Freiburg, Germany. ‘Meta-analysis with multiple treatment groups: an introduction to network meta-analysis’ 

October 2008, Cochrane Colloquium, Freiburg, Germany, Bias Reporting Methods Group. Invited to debate the case for the use of the funnel plot for detecting publication bias in meta-analysis.

July 2008, Presidential address  to the Society for Research Synthesis Methodology. Corfu, Greece. ‘Evidence synthesis as the key to more coherent and efficient research’.

September 2007, Keynote Speaker, Austrian-Swiss Region of the International Biometric Society (IBS), Bern, Switzerland. 'Evidence synthesis and improving efficiency in how we evaluate healthcare’

UK

January 2009 Joint talk for Royal Statistical Society Oxford Section & MSc in Clinical Epidemiology and Decision Making, University of Oxford. ‘Evidence synthesis as the key to more coherent and efficient research’.

October 2008    Keynote speaker at  the conference:RCTs in the Social Sciences, University of York. ‘Evidence synthesis as the key to more coherent and efficient research’.

November 2007  Invited to talk at local RSS group, Nottingham. ‘Including covariates in evidence synthesis’

September 2007  Centre for Reviews and Dissemination, University of York. ‘How to deal with intervention modifiers in evidence synthesis’

July 2007 Conference of the Royal Statistical Society, York. ‘Evidence synthesis for decision making’

May 2007  Department of Health Sciences, University of York. ‘Improving efficiency in how we evaluate healthcare.’

Conference Presentations

October 2008, Cochrane Colloquium, Freiburg, Germany. Formalising the use of evidence synthesis to desing future research coherently and efficiently: a framework proposal. Sutton, A.J., Cooper, N.J., Jones, D.R. (poster)

September 2008, The Society of the Royal Statistical Society, Nottingham, UK. Use of individual participant data (IPD) in meta-analysis of effectiveness studies. Sutton,A.J., Kendrick, D.,  Riley, R.

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POSTGRADUATE SUPERVISION AND TEACHING

I am currently Course Director for the MSc Medical Statistics and am principal supervisor on the following PhD studies:

I will be pleased to discuss possible PhD topics and funding with potential students. Topics could be related to any of the research areas indicated in the section above.

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SELECTED PUBLICATIONS

Journals: 2009, 2008, 2007, 2006, 2004-5, Older

Book Chapters

 

2010
  1. Parekh S, Kwok SC, Pang C,  Hooper L, Loke YK, Ryder JJ, Hing CB, Sutton AJ, Harvey I , Song F. How do systematic reviews deal with publication bias? A survey of current trends and differences between review Journal of Clinical Epidemiology (Provisionally Accepted)
  2. Song F, Parekh S, Hooper L, Loke YK, Ryder J, Sutton AJ, et al. Dissemination and publication of research findings: an updated review of related biases. Health Technol Assess 2010;14(8).
  3. Song FJ, Parekh S, Hooper L, Loke YK, Ryder JJ, Sutton AJ, Hing CB, Harvey I. Extent of publication bias in different categories of research cohorts: a meta-analysis of empirical studies BMC Medical Research Methodology (In press)
  4. Goudie, A.C., Sutton, A.J., Jones, D.R., Donald, A. Empirical assessment suggests existing evidence could be used more fully in designing randomised controlled trials Journal of Clinical Epidemiology (In press)
  5. Peters, J., Sutton, A.J., Jones, D.R., Abrams, K.R., Rushton, L. Assessing publication bias in meta-analysis in the presence of between-study heterogeneity.  JRSS Series A (In Press)
     
2009
  1. Birch, J., Cooper, N,.J., Sutton, A.J. Ades Welton Plamer NICE Flu Report (NHS) (In press)
  2. Peters, J., Sutton, A.J., Jones, D.R., Abrams, K.R., Rushton, L. Assessing publication bias in meta-analysis in the presence of between-study heterogeneity.  JRSS Series A (Provisionally accepted)
  3. Tleyjeh, I.M., Hakim, F. Zimmerman, V. Ibrahim, T., Eriwin, P.J., Sutton, A. Statins for the prevention and treatment of infections: A systematic review and meta-analysis of observational studies. The Archives of Internal Medicine (In Press)
  4. Bown, M., Sutton, A.J., Bolia, A. Subintimal angioplasty: Meta-analytical evidence of clinical utility. European Journal of Vascular and Endovascular Surgery (In press)
  5. Moreno, S.G., Sutton, A.J., Turner, E.H., Ades, A.E., Abrams, K.R., Cooper, N.J., Palmer, T.M. Novel methods to deal with publication bias: “global” application to antidepressant trials where a gold-standard exists. BMJ 2009;339:b2981
  6. Sutton, A.J., Cooper, N.J. Jones, D.R. Role of existing systematic reviews and meta-analyses in the design of future research BMC Medical Research Methodology 2009; 9:29.
  7. Cooper NJ, Sutton AJ, Morris D, Ades A, Welton NJ. Addressing between-study heterogeneity and inconsistency in mixed treatment comparisons: Application to stroke prevention treatments in patients with non-rheumatic Atrial Fibrillation. Stats in Medicine 2009; 28:1861-1881.
  8. Jones, D.R., Peters, J., Rushton, L., Sutton, A.J., Abrams, K.R. Interspecies extrapolation in environmental exposure standard setting: a Bayesian synthesis approach Regul Toxicol & Pharm 2009; 53:217-25.
  9. Kendrick, D., Smith, S., Sutton, A.J., Mulvaney, C., Watson, M., Coupland, C., Woods, A. The effect of education and home safety equipment on childhood thermal injury prevention: meta-analysis and meta-regression. Injury Prevention (In press)
  10. Moreno, S., Sutton, A.J., Stanley, T., Ades, A., Abrams, K.R., Peters, J., Cooper, N.J. Comparison of methods to adjust for publication bias in meta-analysis. BMC Medical Research Methodology 2009, 9:2.
  11. Wailoo, A., Sutton, A.J, Morgan, A. The risk of Febrile Neutropenia in patients with non small cell lung cancer treated with Docetaxel: a systematic review and meta-analysis. British Journal of Cancer 2009; 100:436-441.
  12. Norwood MGA, Sutton AJ, West K, Hemmingway D, Kelly MJ. Lymph node retrieval in colorectal cancer resection specimens: are the national standards achievable and does surgical experience, mode of surgery or preoperative chemo-radiotherapy have an impact on sample numbers?  Colorectal Disease (In Press)
  13. Jones, D.R., Sutton, A.J., Abrams, K, Fenty, J., Warren, F., Rushton, L. Systematic review and meta-analysis of mortality in crop protection product manufacturing workers Occupation and Environmental Medicine 2009; 66:7-15.
  14. Bongartz, T., Warren, F, C., Mines, D., Matterson, E.L., Abrams, K.R., Sutton, A.J. Etanercept therapy in rheumatoid arthritis and the risk of malignancies. A systematic review and individual patient data based meta-analysis of randomized controlled trials. Annals of the Rheumatic Diseases 2009; 68:1177-1183.
  15. Rayt, H.S., Bown, M.J., Sutton, A.J., London, N.J., Sayers, R.D., Bown, M.J. A Meta-analysis and Systematic Review of Endovascular Repair (EVAR) for Ruptured Abdominal Aortic Aneurysm  European Journal of Vascular and Endovascular Surgery (Online early & In press)
  16. Sutton, A.J., Donegan, S., Takwoingi, Y., Garner, P., Gamble, C., Donald, A. An encouraging assessment of methods to inform priorities for updating systematic reviews. Journal of Clinical Epidemiology 2009; 62:241-51.

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2008
  1. Welton, N., Cooper, N.J., Ades, A., Sutton, A.J., Lu, G. Mixed treatment comparison with multiple outcomes reported inconsistently across trials: evaluation of antivirals for treatment of influenza A and B  Statistics in Medicine 2008; 27:5620-5639.
  2. Peters, J.L., Sutton, A.J.,  Jones, D.R., Abrams, K.R., Rushton, L. The contribution of systematic review and meta-analysis methods to human health risk assessment: neurobehavioral effects of manganese Human & Ecol Risk Assessment. 2008;14:1250-1272.
  3. Sutton, A.J., Ades, A.E., Cooper, N.J., Abrams, K.R. Use of indirect and mixed treatment comparisons for technology assessment. Pharmacoeconomics 2008: 26:753-767.
  4. Kendrick, D , Watson, M.C., Mulvaney, C.A., Smith, S.J., Sutton, A.J., Coupland, C.A.C., Mason-Jones, A.J. Preventing childhood falls at home: Meta-analysis and meta-regression. American Journal of Preventative Medicine 2008; 35:370-379.
  5. Pickup, J.C., Sutton, A.J. Severe hypoglycaemia and glycemic control in type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabetic Medicine 2008; 25:765-774.
  6. Palmer, T., Peters, J., Sutton, A.J., Moreno, S. Contour enhanced funnel plots for meta-analysis.  The Stata Journal 2008: 8; 242-254.
  7. Gillies, C.L., Lambert, P.C., Abrams, K.R., Sutton, A.J., Cooper, N.J., Hsu, R., Davies, M.J., Khunti, K. A cost-effectiveness analysis for different strategies for the screening and prevention of type 2 diabetes mellitus. BMJ 2008: 336:1180-1185.
  8. Sutton, A.J., Cooper, N.J., Goodacre, S., Stevenson, M. Integration of meta-analysis and economic decision modelling for evaluating diagnostic tests. Medical Decision Making 2008: 28; 650-667
  9. Kendrick, D., Smith, S., Sutton, A.J., Watson, M., Coupland, C., Mulvaney, C., Mason-Jones, A. Effect of education and safety equipment on poisoning-prevention practices and poisoning: systematic review, meta-analysis and meta-regression.  Archives of Disease in Childhood 2008: 93; 599-608.
  10. Wailoo, A.J., Sutton, A.J., Cooper, N.J., Turner, D.A Abrams, K.R., Brennan,A.,  Nicholson, K.G. Cost effectiveness and value of information analyses of neurominidase inhibitors for the treatment of influenza. Value in Health 2008: 11; 160-171
  11. Peters, J. Sutton, A.J., Jones, D.R., Abrams, K.R., Rushton, L. Contour enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. Journal of Clinical Epidemiology. 2008: 61; 991-996.
  12. Sutton, A.J., Kendrick, D., Coupland, C.A.C. Meta-analysis of individual- and aggregate-level data. Statistics in Medicine 2008; 27:651-669.
  13. Sutton, A.J., Higgins, J.P.T. Recent developments in meta-analysis Statistics in Medicine 2008; 27:625-650.
  14. Lambert, P.C., Billingham, L.J., Cooper, N.J., Sutton, A.J. Abrams, K.R. Establishing the cost-effectiveness of an intervention in a clinical trial when partial cost information is available: A Bayesian approach. Health Economics 2008; 17(1): 57-81.

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2007
  1. Dixon Woods, M., Booth, A., Sutton, A.J. Synthesising qualitative research: a review of published reports. Qualitative Research 2007; 7:375-422.
  2. Gilbody, S., Bower, P., Sutton, A.J. Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes.. Journal of Clinical Epidemiology 2007: 60; 781-785
  3. Cooper, N.J., Sutton, A.J., Ades, A., Paisley, S., Jones, D.R. on behalf of the working group on the ‘use of evidence in economic decision models’. Use of evidence in economic decision models: Practical issues and methodological challenges. Health Economics 2007; 16(12):1277-1286.
  4. Peters, J., Sutton, A.J., Jones, D.R., Abrams, K.R., Rushton, L. Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity Statistics in Medicine 2007; 26:4544-4562.
  5. Lu G, Ades AE, Sutton AJ, Cooper NJ, Briggs AH, Caldwell, DM. Meta-analysis of multiple treatment comparisons at multiple follow-up times.  Statistics in Medicine 2007; 26(20):3681-3699.
  6. Sutton, A.J., Cooper, N.J. Jones, D.R., Abrams, K.A., Lambert, P., Thompson, J.R. Evidence based sample size calculations for future trials based on results of current meta-analyses. Statistics in Medicine 2007; 26(12):2479-24500.
  7. Franks, S.C., Sutton, A.J., Bown, M.J., Sayers, R.D.  Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair. European Journal of Vascular & Endovascular Surgery 2007; 33:154-1571 (First prize winner at European Society for Vascular Surgery AGM in Helsinki Sept 2005)
  8. Riley, R., Abrams, K.R., Sutton, A.J., Lambert, P.C., Thompson, J.R. Bivariate random-effects meta-analysis and the estimation of between-study correlation. BMC Medical Research Methodology 2007; 7:3.
  9. Gillies, C., Abrams, K.A., Lambert, P., Cooper, N.J., Sutton, A.J., Hsu, R., Khunti, K.  Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis. BMJ 2007;334:299-302.
  10. Cooper, N.J., Lambert, P.C., Abrams, K.R., Sutton, A.J. Predicting costs over time using Bayesian Markov chain Monte Carlo methods: an application to early inflammatory polyarthritis. Health Economics 2007; 16:37-56.
  11. Kendrick, D., Coupland, C., Mulvaney, C., Simpson, J. Smith, S.J., Sutton, A., Watson, M., Woods, A. Home safety education and provision of safety equipment for injury prevention. Cochrane Database of Systematic Reviews 2007, CD005014.
  12. Riley, R.D., Abrams, K.R., Lambert, P.C., Sutton, A.J., Thompson, J.R. An evaluation of bivariate random-effects meta-analysis for the joint synthesis of two correlated outcomes. Statistics in Medicine 2007; 26: 78-97.
  13. Dixon-Woods M, Sutton AJ, Shaw RL, Millar T, Smith JA, Young B, Bonas S, Booth A, Jones DR. Appraising qualitative research for inclusion in systematic reviews: a quantitative and qualitative comparison of three methods. Journal of Health Service Research and Policy 2007;12:42-47.

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2006
  1. Peters, J.L., Sutton, A.J., Jones, D.R., Rushton, L., Abrams, K.A. A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. Journal of Environmental Science and Health, Part B 2006;41:1245-1258.
  2. Bower, P., Gilbody, S., Richards, D, Fletcher, J., Sutton, A. Collaborative care for depression in primary care. Making sense of a complex intervention: systematic review and meta-regression. British Journal of Psychiatry. 2006;189:484-493.
  3. Connock, M., Burls, A., Frew, E., Fry-Smith, A., Juarez-Garcia, A., McCabe, C., Wailoo, A.,  Abrams, K.R., Cooper, N.J., Sutton, A.J., Moore, D., Sandercock, J, O’Hagan, A.. The clinical effectiveness and cost-effectiveness of enzyme replacement therapy for Type 1 Gauchers Disease. Health Technology Assessment (& also Submitted to NICE) 2006; 10(24):1-136.
  4. Locker, T., Goodacre, S., Sampson, F., Webster, A., Sutton, A. Meta-analysis of plethysmography and rheography in the diagnosis of deep vein thrombosis. Emergency Medicine Journal 2006;25:630-635.
  5. Martin, J., Williams, K., Sutton, A.J., Abrams, K.R. Systematic review and meta-analysis of methods of diagnostic assessment for urinary incontinence. Neurourology and Urodynamics 2006; 25:674-683.
  6. Norwood, M.G.A., Sayers, R.D., Roscher, S., Lynch, N.J., Sutton, A.J., Schwaeble, W.J. Consumption of mannan-binding lectin during abdominal aortic aneurysm repair. European Journal of Vascular & Endovascular Surgery. 2006;31:239-43
  7. Fenwick, E., Palmer, S., Claxton, K, Sculpher, M., Abrams, K., Sutton, A. An iterative Bayesian approach to cost-effectiveness and value of information analysis: Application to a policy of pre-operative optimization employing dopexamine or adrenaline for patients undergoing major elective surgery. Medical Decision Making 2006; 26:480-496.
  8. Gilbody, S., Bower, P., Fletcher, J., Richards, D., Sutton, A.J. Collaborative care for depression:  A  cumulative meta-analysis and review of longer-term outcomes.  Archives of Internal Medicine 2006;166:2314-2321.
  9. Dixon-Woods, M. Krik, D., Agarwal, S. Annandale, E., Arthur, T., Harvey, J., Hsu, R. Katbamna, S., Olsen, R., Smith, L., Riley, R., Sutton, A. Conducting a critical interpretive review of the literature on access to healthcare by vulnerable groups. BMC Medical Research Methodology 2006; 6:35 doi:10.1186/1471-2288-6-35
  10. Angell, E., Sutton, A.J., Windridge, K., Dixon-Woods, M. Consistency in research ethics committee decision-making: a controlled comparison. Journal of Medical Ethics 2006; 32:662-664
  11. Goodacre, S., Stevenson, M., Wailoo, A., Sampson, F., Sutton, A.J., Thomas, S.  How should we diagnose suspected deep-vein thrombosis? QJM 2006; 99:377-388.
  12. Alder, N., Fenty, J., Warren, F., Sutton, A.J., Rushton, L., Jones, D.R., Abrams, K. Systematic review and meta-analysis of mortality and cancer incidence among workers in the synthetic rubber producing industry. The American Journal of Epidemiology 2006; 164:405-420.
  13. Cooper, N.J., Sutton, A.J., Lu, G., Khunti, K. Mixed comparison of stroke prevention treatments in individuals with non-rheumatic atrial fibrillation. Archives of Internal Medicine 2006; 166:1269-1275.
  14. Goodacre, S., Sampson, F., Stevenson, M., Wailoo, A., Sutton, A., Thomas, S., Locker, T., Ryan, A. Measurement of the clinical and cost-effectiveness of non-invasive diagnostic testing strategies for deep vein thrombosis. Health Technology Assessment 2006; 10(15):1-168.
  15. Bongartz, T., Sutton, A.J., Sweeting, M., Buchan, I., Matteson, E.L., Montori, V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: a systematic review and meta-analysis of randomized controlled trials. JAMA 2006; 295:2275-2285.
  16. Bandera, E., Botteri, M., Minelli, C., Sutton, A., Abrams, K.R., Latronico, N. Cerebral Blood Flow Threshold of Ischemic Penumbra and Infarct Core in Acute Ischemic Stroke. A Systematic Review  Stroke 2006; 37:1334-1339.
  17. Ades, A., Sculpher, M., Sutton, A.J., Cooper, N.J., Abrams, K.R., Welton, N., Lu, G. Bayesian Methods for Evidence Synthesis in Cost-Effectiveness Analysis. Pharmacoeconomics 2006; 24:1-19.
  18. Martin J, Williams KS, Abrams KR, Turner D, Sutton AJ, Chapple C, Assassa RP, Shaw C, Cheater F, Edmunds-Otter M, Juarez Garcia A. Systematic review and evaluation of methods of assessing urinary incontinence. Health Technology Assessment 2006; 10 (6): 1-132.
  19. Peters, J., Sutton, A.J., Jones, D.R., Abrams, K.R., Rushton, L.  Comparison of two methods to detect publication bias in meta-analysis. JAMA 2006; 295: 676-80
  20. Dixon-Woods, M., Bonas, S., Booth, A., Jones, D., Miller, T., Sutton, A.J., Shaw, R., Smith, J., Young, B. How can systematic qualitative reviews incorporate qualitative research? A critical perspective. Qualitative Research. 2006; 6:27-44.
  21. Ades, A.E., Sutton, A.J. Multi-parameter evidence synthesis in epidemiology and medical decision making: current approaches. The Journal of the Royal Statistical Society Series A. 2006; 169:5-36.
  22. Turner, D.A., Nicholson, K.G., Wailoo, A., Cooper N.J., Sutton, A, Abrams, K. The cost-effectiveness of influenza vaccination in adults aged 50 to 64. Vaccine. 2006; 24:1035-1043.

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2004-5
  1. Goodacre, S., Sampson, F. Sutton, A.J., Mason, S., Morris, F. Variation in the diagnostic performance of D-dimer for suspected deep vein thrombosis: systematic review, meta-analysis and meta-regression. Quarterly Journal of Medicine 2005; 98:513-527.
  2.  Goodacre, S., Sampson, F., Thomas, S., van Beek, E., Sutton, A.J. Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis. BMC Medical Imaging 2005; 5
  3. Whittaker, A.L., Sutton, A.J., Beardsmore, C.S. Are ethnic differences in lung function explained by chest size? Archives of Disease in Childhood Fetal & Neonatal Edition. 2005;90(5):F423-8.
  4. Jackson, D., Copas, J., Sutton, A. Modelling reporting bias: The operative reporting rate for ruptured abdominal aortic aneurysm repair Journal of the Royal Statistical Society Series A. 2005; 168:737-752.
  5. Cooper, N.J., Coyle, D., Abrams, K.R., Mugford, M., Sutton, A.J. Use of evidence in decision models: an appraisal of health technology assessments in the UK since 1997. Journal of Health Services Research & Policy. 2005; 10: 245-250.
  6. Goodacre, S., Sutton, A.J., Sampson, F. The value of clinical assessment in the diagnosis of deep vein thrombosis: systematic review and meta-analysis. Annals of Internal Medicine. 2005; 143:129-139.
  7. Cooper, N.J., Jones, D.R., Sutton, A.J., The use of systematic reviews when designing new studies. Clinical Trials. 2005;2:260-264.
  8. El Kadiki, A.#, Sutton, A.J.# The Role of Multivitamins and Mineral Supplements in Preventing Infections in the Healthy Elderly: A Systematic review & Meta-Analysis of Randomised Control Trials BMJ. 2005;330:871-874 (# Joint first author)      
     
                          i. Sutton, A.J., El Kadiki, A. Assessing concerns regarding the validity of three trials included in “Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials” BMJ (website only addendum http://bmj.bmjjournals.com/cgi/content/full/bmj.38399.495648.8F/DC2)
  9. Lambert, P.C., Sutton, A.J., Burton, P., Abrams, K.R., Jones, D.R. How vague is vague? Assessment in the use of vague prior distributions for variance components. Statistics in Medicine 2005; 24:2401-2428.
  10. Dixon-Woods, M., Agarwal, S., Jones, D.R., Young, B., Sutton, A. Synthesising qualitative and quantitative evidence in reviews: a review of methods. Journal of Health Services Research & Policy 2005; 10:45-53. (Reprinted in Bryman A (ed) (2006) Mixed Methods (Vol 3) London: Sage)
  11. Peters, J.L., Jones, D.R., Rushton, L., Sutton, A.J., Abrams, K.R., Mugglestone, M.A. Bayesian methods for the cross design synthesis of epidemiological and toxicological evidence. Journal of the Royal Statistical Society Series C 2005; 54:159-172
  12. Sutton, A.J., Cooper, N.J., Abrams, K.R., Lambert, P.C., Jones, D.R. A Bayesian approach to evaluating net clinical benefit allowed for parameter uncertainty. Journal of Clinical Epidemiology 2005; 58: 26-40
  13. Norwood, M.G.A., Bown, M. Sutton, A.J., Micholson, M., Sayers,R. Interleukin-6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the lower limbs British Journal of Surgery 2004; 91(9):1153-6
  14. Riley, R.D., Sutton, A.J., Abrams, K.R., Lambert, P.  Sensitivity analyses allowed more appropriate and reliable meta-analysis conclusions for multiple outcomes when missing data was present. Journal of Clinical Epidemiology 2004; 57:911-924
  15. Khunti, K., Squire, I., Abrams, K.R., Sutton, A.J. Accuracy of a 12-lead electrocardiogram in screening patients with suspected heart failure for open access echocardiography: a systematic review and meta-analysis European Journal of Heart Failure 2004; 6:571-576
  16. Riley, R.D., Heney, D., Jones, D.R., Sutton, A.J., Lambert, P.C., Abrams, K.R., Young, B., Wailoo, A.J., Burchill, S.A. A systematic review of molecular and biological tumour markers in neuroblastoma Clinical Cancer Research 2004;10(1):4-12
  17. Siebenhofer, A., Plank, J., Horvath, K., Berghold, A., Sutton, A.J., Sommer, R.,  Pieber, T.R.. Angiotensin receptor blockers for patients with diabetes mellitus: Meta-analysis of controlled double blind randomized trials. Diabetic Medicine 2004; 21(1):18-25
  18. Shaw, R.L., Booth, A., Sutton, A.J., Miller, T., Smith, J.A., Young, B., Jones, D.R., Dixon-Woods, M. Finding qualitative research: a literature searching study BMC Medical Research Methodology 2004; 4:5
  19. Cooper, N.J., Sutton, A.J., Abrams, K.R., Turner, D., Wailoo, A. Comprehensive decision analytical modelling in economic evaluation: A Bayesian approach. Health Economics 2004; 13:203-226
  20. Poulakis, V., Dahm, P., Witzsch, U., Sutton, A.J., Becht, E. Transurethral electrovaporization vs transurethral resection for symptomatic prostatic obstruction: a meta-analysis. British Journal of Urology 2004; 94:89-95
  21. Norwood, M.G.A., Polimenovi, N.M., Sutton, A.J., Bown, M.J., Sayers, R.D. Abdominal aortic aneurysm repair in patients with chronic renal disease. The European Journal of Vascular and Endovascular Surgery 2004; 27:287-291
  22. Minelli, C., Abrams, K.R., Sutton, A.J., Cooper, N.J.  Benefits and harms associated with hormone replacement therapy: clinical decision analysis BMJ 2004; 328:371-375
  23. Sweeting, M.J., Sutton, A.J., Lambert, P.C. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Statistics in Medicine 2004; 23:1351-1375
  24. Bown, M.J., Cooper, N.J., Sutton, A.J., Prytherch, D, Nicholson, M.L., Bell, P.R.F., Sayers, R.D. The post-operative mortality of ruptured abdominal aortic aneurysm repair European Journal of Vascular and Endovascular Surgery 2004; 27:65-74

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Older
  1. Cooper, N.J., Sutton, A.J., Abrams, K.R., Wailoo, A., Turner, D., Nicholson, K.G. Effectiveness of neuraminidase inhibitors in the treatment and prevention of influenza A and B: Systematic review and meta-analysis of randomised controlled trials.  BMJ 2003; 326:1235-1238
  2. Riley, R.D., Abrams, K.R., Sutton, A.J., Lambert, P.C., Jones, D.R., Heney, D., Burchill, S.A. Reporting of prognostic markers: current problems and development of guidelines for evidence-based practice in the future British Journal of Cancer 2003; 88:1191-1198
  3. Riley, R.D., Burchill, S.A., Abrams, K.R., Heney, D., Sutton, A.J., Jones, D.R., Lambert, P.C., Young, B., Wailoo, A.J., Lewis, I.J. A Systematic Review Of Molecular And Biological Markers In Tumours Of The Ewing’s Sarcoma Family. European Journal of Cancer 2003; 39:19-30
  4. Cooper, N.J., Abrams,K.R., Sutton, A.J., Turner,D., Lambert, P.C. Use of Bayesian methods for Markov modelling in cost-effectiveness analysis: An application to taxane use in advanced breast cancer. Journal of the Royal Statistical Society Series A 2003;166:389-405
  5. Riley, R.D., Burchill, S.A., Abrams, K.R., Heney, Lambert, P.C., D., Jones, D.R., Sutton, A.J., Young, B., Wailoo, A.J., Lewis, I.J. Systematic review and evaluation of the use of tumour markers in paediatric oncology: Ewing’s sarcoma and neuroblastoma. Health Technology Assessment 2003;7(5):1-162
  6. Turner, D., Wailoo, A., Nicholson, K., Cooper, N., Sutton, A., Abrams, K. Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Health Technology Assessment. 2003; 7(35):1-182. (Version also published as report 67 for National Institute for Clinical Excellence (NICE))
  7. Brown, J.J., Datta, V., Sutton, A.J., Swift, P.G.F. Suppression of TSH in congenital hypothyroidism is significantly related to serum levels and dosage of thyroxin. Hormone Research 2003;59:85-90
  8. Cooper, N.J., Sutton, A.J., Mugford, M. Abrams, K.R. Use of Bayesian Markov Chain Monte Carlo methods to model cost data. Medical Decision Making 2003;23:38-53.
  9. Sutton, A.J., Cooper, N.J., Lambert, P.C., Jones, D.R., Abrams, K.R., Sweeting, M.J. Meta-analysis of rare and adverse event data. Expert Review of Pharmacoeconomics & Outcomes Research. 2002; 2, 367-379.
  10. Cooper, N.J., Sutton, A.J., Abrams, K.R. Decision analytical economic modeling within a Bayesian statistical framework: application to prophylaxis antibiotics use for caesarian section. Statistical Methods in Medical Research. 2002; 11:491-512.
  11. Sutton, A.J., Abrams, K.A., Jones, D.R. Generalised synthesis of evidence and the threat of publication bias: the example of electronic fetal heart rate monitoring (EFM). Journal of Clinical Epidemiology. 2002; 55:1013-1024.
  12. Bown, M.J., Sutton, A.J., Nicholson, M.L., Bell, P. R.F. A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair. British Journal of Surgery. 2002; 89:1-18.
  13. Song,F., Khan, K.S., Dinnes, J, Sutton, A.J. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. International Journal of Epidemiology. 2002; 31:88-95.
  14. Lambert, P.C., Sutton, A.J., Abrams, K.R., Jones, D.R. A comparison of summary patient level covariates in meta-regression with individual patient data meta-analyses. Journal of Clinical Epidemiology. 2002; 55:86-94.
  15. Sutton,A.J., Abrams,K.R. Bayesian Methods in Meta-Analysis & Evidence Synthesis Statistical Methods in Medical Research. 2001; 10:277-303.
  16. Sutton, A.J., Muir,K.R., Mockett,S., Fentem,P. A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey. The Annals of the Rheumatic Diseases. 2001; 60:756-764.
  17. Song, F., Sheldon, T.A., Sutton, A.J., Abrams, K.A., Jones, D.R. Methods for exploring heterogeneity in meta-analysis. Evaluation and the Health Professions. 2001; 24:126-151.
  18.  Sutton, A.J., Abrams, K.R., Jones,D.R. An illustrated guide to the methods of meta-analysis. Journal of Evaluation in Clinical Practice. 2001; 7:135-148.
  19. Sutton, A.J., Song, F., Gilbody, S.M., Abrams, K.R. Modelling publication bias in meta-analysis: a review. Statistical Methods in Medical Research. 2000; 9:421-445.
  20. McDonagh,M.S., Whiting,P.F., Wilson,P.M., Sutton,A.J., Chestnutt,I., Cooper,J., Misso,K., Bradley,M., Treasure,E., Kleijnen,J. Systematic review of water fluoridation. BMJ. 2000; 321:855-859.
  21. Sutton, A.J., Duval,S., Tweedie,R., Abrams,K,R., Jones,D.R. Empirical assessment of effect of publication bias on meta-analyses. BMJ 2000; 320:1574-1577.
  22. Gilbody, S.M., Song, F. Eastwood, A.J., Sutton, A. The causes, consequences and detection of publication bias in psychiatry. Acta Psychiatrica Scandinavica. 2000; 102:241-249.
  23. Song,F., Eastwood,A., Gilbody,S., Duley,L., Sutton, A.J. Publication and other selected biases in systematic reviews. Health Technology Assessment. 2000;4(10).
  24. Hellmich,M., Abrams,K.R., Sutton,A.J. Bayesian approaches to meta-analysis of ROC curves: a comparative review. Medical Decision Making. 1999; 19(3):252-64.
  25. Siebenhofer, A. Kemp, C. Sutton, A. Williams, B. The reproducibility of central aortic blood pressure measurements in healthy subjects using applanation tonometry and sphygmocardiography. Journal of Human Hypertension. 1999; 13(9):625-9.
  26. Sutton,A.J., Jones,D.R., Abrams,K.R., Sheldon,T.A., Song,F. Systematic Reviews and Meta-Analysis: a Structured Review of the Methodological Literature. Health Services Research and Policy. 1999;4:49-55.
  27. Sutton,A.J., Abrams,K.R., Jones,D.R., Sheldon,T.A., Song,F. Systematic reviews of trials and other studies. Health Technology Assessment. 1998;2(19).
  28. Hardy,C.J., Palmer,B.P., Muir,K.R., Sutton, A.J., Powell,R.J. Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study. Annals of the Rheumatic Diseases.1998;57(8):451-455.

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Book Chapters

Jones, D.R., Sutton, A.J., Peters, J. Meta-analysis in non-clinical risk assessment. In the Wiley Encyclopaedia of Quantitative Risk Assessment. Wiley, Chichester, UK. 2008

Sterne JAC, Egger M, Moher D (editors). Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Intervention. Version 5.0.0 (updated February 2008). The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org. (Contributing authors: James Carpenter, Matthias Egger, Roger Harbord, Julian Higgins, David Jones, David Moher, Jonathan Sterne, Alex Sutton, Jennifer Tetzlaff.)

Riley RD, Abrams KR, Lambert PC, Sutton AJ, Altman DG. Where next for evidence synthesis of prognostic marker studies? Improving the quality and reporting of primary studies to facilitate clinically relevant evidence-based results. In: Molenberghs G (ed). Proceedings of the Statistics in Health Sciences Conference Nantes 2004.  Birkhauser and Springer (2006) (In press).

Dixon-Woods, M., Agarwal, S., Young, B., Jones, D.R., Sutton, A.J. Integrative approaches to qualitative and quantitative evidence. Report for the Health Development Agency. (In press)

Sutton, A.J. Evidence concerning the consequences of publication and related biases. In Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments. Ed. Rothstein,H., Sutton,A.J. and Borenstein,M. Wiley, Chichester (2005)
 
Sutton, A.J. Pigott, T. Bias in meta-analysis induced by incompletely reported studies. In Publication Bias in Meta-Analysis: Prevention, Assessment and Adjustments. Ed. Rothstein, H., Sutton, A.J. and Borenstein, M. Wiley, Chichester (2005)

Sterne,J.A.C., Egger,M., Sutton.A.J. Meta-analysis software. In Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd Edition of Systematic Reviews. Ed. Egger,M., Davey Smith,G., Altman,D.G. (Eds.) London: BMJ Books. (2001).

Sutton,A.J., Jones,D.R., Abrams,K.R., Sheldon,T.A., Song,F. Systematic Reviews Of Trials And Other Studies. In Handbook of Research Methods for Evidence-based health care - Insights from the NHS HTA Programme. Ed. Stevens,A., Abrams,K., Brazier,J., Fitzpatrick,R., Lilford,R. London: Sage Publications. (2001).

Song,F., Easterwood,A., Gilbody,S., Duley,L., Sutton, A.J.  Publication bias. In Handbook of Research Methods for Evidence-based health care - Insights from the NHS HTA Programme. Ed. Stevens,A., Abrams,K., Brazier,J., Fitzpatrick,R., Lilford,R. London: Sage Publications. (2001).

Sutton,A.J., Abrams,K.R., Jones,D.R., Sheldon,T.A., Song,F. Methods for Meta-analysis in Medical Research. London: John Wiley (2000)

Sutton, A.J., Lambert,P.C. Hellmich,M., Abrams,K.R., Jones,D.R. Meta-analysis in practice: A critical review of available software. In Meta-Analysis in Medicine and Health Policy. Ed. Berry, D.A. Stangl.D,K. Marcel Dekker, NY (2000).

Sutton, A.J., Jones, D.R., Abrams, K.R., Sheldon,T.A., Song, F. Systematic Reviews of Randomised Trials. In Health Services Research Methods: A guide to best practice. Chapter 16 Pages 175-186. Ed. Black, N., Brazier, J., Fitzpatrick, R.,Reeves, B. London: BMJ Books. 1998.

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